Effects of the Finnish Alzheimer Disease Exercise Trial (FINALEX): A randomized controlled trial

JAMA Internal Medicine

Volumn 173, Issue 10, 2013, Pages 894-901

  Pitkäl̈a, Kaisu H ^a,b   Pöysti, Minna M ^a,b,c   Laakkonen, Marja Liisa ^a,b,d   Tilvis, Reijo S ^a,b   Savikko, Niina ^a,b   Kautiainen, Hannu ^a,b   Strandberg, Timo E ^a,b,e  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c SOCIAL INSURANCE INSTITUTION   (Finland)

^d City of Helsinki   (Finland)

^e OULU UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL EFFECTIVENESS; COMMUNITY CARE; CONTROLLED STUDY; DETERIORATION; FALLING; FEMALE; FOLLOW UP; FUNCTIONAL INDEPENDENCE MEASURE; GROUP THERAPY; HEALTH CARE COST; HEALTH CARE UTILIZATION; HEALTH PROGRAM; HOME CARE; HOMEBOUND PATIENT; HUMAN; KINESIOTHERAPY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OUTCOME ASSESSMENT; PATIENT MOBILITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SHORT PHYSICAL PERFORMANCE BATTERY; SOCIAL WORK; SPOUSE; TREATMENT REFUSAL;

ACTIVITIES OF DAILY LIVING; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CAREGIVERS; DAY CARE; EXERCISE THERAPY; FEMALE; FINLAND; FOLLOW-UP STUDIES; HOUSE CALLS; HUMANS; INDEPENDENT LIVING; MALE; PHYSICAL THERAPISTS; PROSPECTIVE STUDIES; QUALITY OF LIFE; TREATMENT OUTCOME;

EID: 84878484435     PISSN: 21686106     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamainternmed.2013.359     Document Type: Article

References (29)

1. Cotter VT. The burden of dementia. Am J Manag Care. 2007;13(suppl 8):S193-S197.
2. Gillette Guyonnet S, Abellan Van Kan G, Alix E, et al; International Academy on Nutrition and Aging Expert Group. IANA (International Academy on Nutrition and Aging) Expert Group: weight loss and Alzheimer's disease. J Nutr Health Aging. 2007;11(1):38-48. (Pubitemid 46424268)
3. Tinetti ME, Speechley M, Ginter SF. Risk factors for falls among elderly persons living in the community. N Engl J Med. 1988;319(26):1701-1707. (Pubitemid 19019577)
4. Olazarán J, Reisberg B, Clare L, et al. Nonpharmacological therapies in Alzheimer's disease: a systematic review of efficacy. Dement Geriatr Cogn Disord. 2010;30(2):161-178.
5. Liu CJ, Latham NK. Progressive resistance strength training for improving physical function in older adults. Cochrane Database Syst Rev. 2009;(3):CD002759.
6. Bellelli G, Morandi A, Gentile S, Trabucchi M. Rehabilitation of elderly adults with severe cognitive impairment: it is time for evidence. J Am Geriatr Soc. 2012;60(5):998-999.
7. Shaw FE, Bond J, Richardson DA, et al. Multifactorial intervention after a fall in older people with cognitive impairment and dementia presenting to the accident and emergency department: randomised controlled trial [published correction appears in BMJ. 2003;326(7391):699]. BMJ. 2003;326(7380):73.
8. Teri L, Gibbons LE, McCurry SM, et al. Exercise plus behavioral management in patients with Alzheimer disease: a randomized controlled trial. JAMA. 2003;290(15):2015-2022. (Pubitemid 37430584)
9. Rolland Y, Pillard F, Klapouszczak A, et al. Exercise program for nursing home residents with Alzheimer's disease: a 1-year randomized, controlled trial. J Am Geriatr Soc. 2007;55(2):158-165. (Pubitemid 46184389)
10. Hauer K, Schwenk M, Zieschang T, Essig M, Becker C, Oster P. Physical training improves motor performance in people with dementia: a randomized controlled trial. J Am Geriatr Soc. 2012;60(1):8-15.
11. Pitkälä KH, Raivio M, Laakkonen ML, Tilvis RS, Strandberg TE. Exercise rehabilitation on home-dwelling patients with Alzheimer's disease: a randomized, controlled trial. Trials. 2010;11:92. doi:10.1186/1745-6215-11-92.
12. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34(7):939-944. (Pubitemid 14076461)
13. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373-383. (Pubitemid 17055592)
14. Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL. A new clinical scale for the staging of dementia. Br J Psychiatry. 1982;140(Jun):566-572. (Pubitemid 12124384)
15. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189-198.
16. Guigoz Y, Lauque S, Vellas BJ. Identifying the elderly at risk for malnutrition: the Mini Nutritional Assessment. Clin Geriatr Med. 2002;18(4):737-757. (Pubitemid 35239179)
17. Pollak N, Rheault W, Stoecker JL. Reliability and validity of the FIM for persons aged 80 years and above from amultilevel continuing care retirement community. Arch Phys Med Rehabil. 1996;77(10):1056-1061. (Pubitemid 26339631)
18. Guralnik JM, Simonsick EM, Ferrucci L, et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994;49(2):M85-M94. (Pubitemid 24100267)
19. Granger CV, Hamilton BB, Keith RA, Zielezny M, Sherwin FS. Advances in functional assessment for medical rehabilitation. Top Geriatr Rehabil. 1986;1(3):59-74.
20. Hannan MT, Gagnon MM, Aneja J, et al. Optimizing the tracking of falls in studies of older participants: comparison of quarterly telephone recall with monthly falls calendars in the MOBILIZE Boston Study. Am J Epidemiol. 2010;171(9):1031-1036.
21. Hujanen T, Kaipiainen S, Tuominen U, Pekurinen M. Unit Costs of Health Care in Finland in 2006 [in Finnish]. Helsinki, Finland: STAKES; 2008.
22. Väisänen A, Hujanen T. Unit Costs of Social Care in Finland in 2007 [in Finnish]. National Institute for Health and Welfare. Helsinki, Finland: Yliopistopaino; 2010.
23. Schulz R, Beach SR. Caregiving as a risk factor for mortality: the Caregiver Health Effects Study. JAMA. 1999;282(23):2215-2219. (Pubitemid 30002964)
24. Tappen RM, Roach KE, Applegate EB, Stowell P. Effect of a combined walking and conversation intervention on functional mobility of nursing home residents with Alzheimer disease. Alzheimer Dis Assoc Disord. 2000;14(4):196-201.
25. Schwenk M, Zieschang T, Oster P, Hauer K. Dual-task performances can be improved in patients with dementia: a randomized controlled trial. Neurology. 2010;74(24):1961-1968.
26. Roach KE, Tappen RM, Kirk-Sanchez N, Williams CL, Loewenstein D. A randomized controlled trial of an activity specific exercise program for individuals with Alzheimer disease in long-term care settings. J Geriatr Phys Ther. 2011;34(2):50-56.
27. Graff MJ, Vernooij-Dassen MJ, Thijssen M, Dekker J, Hoefnagels WH, Rikkert MG. Community based occupational therapy for patients with dementia and their care givers: randomised controlled trial [published online November 17, 2006]. BMJ. 2006;333(7580):1196.
28. Pitkälä KH, Raivio M, Laakkonen ML, Tilvis RS, Kautiainen H, Strandberg TE. Exercise rehabilitation on home living patients with Alzheimer's disease: a randomized, controlled trial: baseline findings and feasibility. Eur Geriatr Med. 2011; 2(6):338-343.
29. Panel on Prevention of Falls in Older Persons, American Geriatrics Society and British Geriatrics Society. Summary of the updated American Geriatrics Society/British Geriatrics Society clinical practice guideline for prevention of falls in older persons. J Am Geriatr Soc. 2011;59(1):148-157.