Exercise-induced pulmonary haemorrhage during submaximal exercise

Equine Veterinary Journal

Volumn 38, Issue SUPPL.36, 2006, Pages 502-507

  Epp, T S ^a   Mcdonough, P ^a   Padilla, D J ^a   Gentile, J M ^a   Edwards, K L ^a   Erickson, H H ^a   Poole, D C ^a  

^a KANSAS STATE UNIVERSITY   (United States)

Author keywords

Bronchoalveolar lavage; Bumonary haemorrage; Exercise induced; Horse; Submaximal exercise

Indexed keywords

EQUIDAE;

EID: 84878465106     PISSN: 04251644     EISSN: 20423306     Source Type: Journal    
DOI: 10.1111/j.2042-3306.2006.tb05595.x     Document Type: Article

References (41)

1. Art, T., Serteyn, D. and Lekeux, P. (1988) Effect of exercise on the partitioning of equine respiratory resistance. Equine vet. J. 20, 268-273.
2. Attenburrow, D. P. and Goss, V. A. (1982) The mechanical coupling of lung ventilation to locomotion in the horse. Med. Eng. Phys. 16, 188-192.
3. Bayly, W., Schott II, H. and Slocombe, R. (1995) Ventilatory response of horses to prolonged sub-maximal exercise. Equine vet. J., Suppl. 18, 23-28.
4. Birks, E. K., Mathieu-Costello, O., Fu, Z., Tyler, W. S. and West, J. B. (1997) Very high pressures are required to cause stress failure of pulmonary capillaries in Thoroughbred racehorses. J. appl. Physiol. 82, 1584-1592.
5. Bramble, D. M. and Carrier, D. (1983) Running and breathing in mammals. Science 219, 251-256.
6. Clark, C. K., Lester, G. D., Vetro, T. and Rice, B. (1995) Bronchoalveolar lavage in horses: effect of exercise and repeated sampling on cytology. Aust. vet. J. 72, 249-252.
7. Cook, W. R., Williams, R. M., Kirker-Head, C. A. and Verbridge, D. J. (1988) Upper airway obstruction (partial asphyxia) as the possible cause of exercise-induced pulmonary haemorrhage in the horse: an hypothesis. J. equine vet. Sci. 8, 11-26.
8. Ducharme, N. G., Hackett, R. P., Gleed, R. D., Ainsworth, D. M., Erb, H. N., Mitchell, L. M. and Soderholm, L. V. (1999) Pulmonary capillary pressure in horses undergoing alteration of pleural pressure by imposition of various upper airway resistive loads. Equine vet. J., Suppl. 30, 27-33.
9. Elliot, A. R., Fu, Z., Tsukimoto, K., Prediletto, R., Mathieu-Costello, O. and West, J. B. (1992) Short-term reversibility of ultrastructural changes in pulmonary capillaries caused by stress failure. J. appl. Physiol. 73, 1150-1158.
10. Epp, T. S., McDonough, P., Padilla, D. J., Cox, J. H., Poole, D. C., and Erickson, H. H. (2005) The effect of herbal supplementation on the severity of exercise-induced pulmonary haemorrhage. Equine Comp. Exerc. Physiol. 2, 17-25.
11. Erickson, B. K., Erickson, H. H. and Coffman, J. R. (1990) Pulmonary artery, aortic, and oesophageal pressure changes during high intensity treadmill exercise in the horse: a possible relation to exercise-induced pulmonary haemorrhage. Equine vet. J., Suppl. 9, 47-52.
12. Erickson, B. K., Erickson, H. H. and Coffman, J. R. (1992) Pulmonary artery and aortic pressure changes during high intensity treadmill exercise in the horse: effect of frusemide and phentolamine. Equine vet. J. 24, 215-219.
13. Fedde, M. R. (1991) Blood gas analysis on equine blood: required correction factors. Equine vet. J. 23, 410-412.
14. Fu, X., Costello, M. L., Tsukimoto, K., Prediletto, R., Elliot, A. R., Mathieu-Costello, O. and West, J. B. (1992) High lung volume increases stress failure in pulmonary capillaries. J. appl. Physiol. 73, 123-133.
15. Geor, R. J., Ommundson, L., Fenton, G. and Pagan, J. D. (2001) Effects of an external nasal strip and frusemide on pulmonary haemorrhage in Thoroughbreds following high-intensity exercise. Equine vet. J. 33, 577-584.
16. Hildreth, T. S., McDonough, P., Padilla, D. J., Behnke, B. J., Poole, D. C. and Erickson, H. H. (2003) Is immunotherapy effective in reducing exercise-induced pulmonary haemorrhage (EIPH). FASEB Journal 17, A939.
17. Holcombe, S. J., Berney, C., Cornelisse, C. J., Derksen, F. J. and Robinson, N. E. (2002) Effect of commercially available nasal strips on airway resistance in exercising horses. Am. J. vet. Res. 63, 1101-1105.
18. Hopkins, S. R., Bayly, W. M., Slocombe, R. F., Wagner, H. and Wagner, P. D. (1998) Effect of prolonged heavy exercise on pulmonary gas exchange in horses. J. appl. Physiol. 84, 1723-1730.
19. Hornicke, H., Meixner, R. and Pollmann, U. (1983) Respiration in exercising horses. In: Equine Exercise Physiology, Eds: D. H. Snow, S. G. B. Persson and R. J. Rose, Granta Editions, Cambridge, pp 7-16.
20. Jackson, J. A., Ducharme, N. G., Hackett, R. P., Rehder, R. S., Ainsworth, D. M., Shannon, K. J., Erickson, B. K., Erb, H. N., Jansson, N., Soderholm, L. V. and Thorson, L. M. (1997) Effects of airway obstruction on transmural pulmonary artery pressure in exercising horses. Am. J. vet. Res. 58, 897-903.
21. Kindig, C. A., McDonough, P., Fenton, G., Poole, D. C. and Erickson, H. H. (2001a) Efficacy of nasal strip and furosemide in mitigating EIPH in thoroughbred horses. J. appl. Physiol. 91, 1396-1400.
22. Kindig, C. A., McDonough, P., Finley, M. R., Behnke, B. J., Richardson, T. E., Marlin, D. J., Erickson, H. H. and Poole, D. C. (2001b) NO inhalation reduces pulmonary arterial pressure but not haemorrhage in maximally exercising horses. J. appl. Physiol. 91, 2674-2678.
23. Kindig, C. A., Ramsel, C., McDonough, P., Poole, D. C. and Erickson, H. H. (2003) Inclined running increases pulmonary haemorrhage in the Thoroughbred horse. Equine vet. J. 35, 581-585.
24. Langsetmo, I., Fedde, M. R., Meyer, T. S. and Erickson, H. H. (2000) Relationship of pulmonary arterial pressure to pulmonary haemorrhage in exercising horses. Equine vet. J. 32, 379-384.
25. Lapointe, J. M., Vrins, A. and Lavoie, J. P. (1994) Effects of centrifugation and specimen preparation technique on bronchoalveolar lavage analysis in horses. Equine vet. J. 26, 227-229.
26. McDonough, P., Kindig, C. A., Ramsel, C., Poole, D. C. and Erickson, H. H. (2002a) The effect of treadmill incline on maximal oxygen uptake, gas exchange, and the metabolic response to exercise in the horse. Expt. Physiol. 87, 499-506.
27. McDonough, P., Kindig, C. A., Erickson, H. H. and Poole, D. C. (2002b) Mechanistic basis for the gas exchange threshold in Thoroughbred horses. J. appl. Physiol. 92, 1499-1505.
28. McDonough, P., Kindig, C. A., Hildreth, T. S., Padilla, D. J., Behnke, B. J., Erickson, H. H. and Poole, D. C. (2004) Effect of furosemide and the equine nasal strip on EIPH and time to fatigue in running Thoroughbred horses. Equine comp. Exerc. Physiol. 1, 177-184.
29. McKane, S. A. and Rose, R. J. (1993) Radiographic determination of the location of a blindly placed bronchoalveolar lavage catheter. Equine vet. J. 25, 329-332.
30. McKane, S. A. and Slocombe, R. F. (2002) Alveolar fibrosis and changes in equine lung morphometry in response to intrapulmonary blood. Equine vet. J., Suppl. 34, 451-458.
31. McKane, S. A., Canfield, P. J. and Rose, R. J. (1993) Equine bronchoalveolar lavage cytology: survey of Thoroughbred racehorses in training. Aust. vet. J. 70, 401-404.
32. Meyer, T. S., Fedde, M. R., Gaughan, E. M., Langsetrno, I. and Erickson, H. H. (1998) Quantification of exercise-induced pulmonary haemorrhage with bronchoalveolar lavage. Equine vet. J. 30, 284-288.
33. O'Callaghan, M. W., Pascoe, J. R., Tyler, W. S. and Mason, D. K. (1987a) Exercise-induced pulmonary haemorrhage in the horse: results of a detailed clinical, post mortem and imaging study. V. microscopic observations. Equine vet. J. 19, 411-418.
34. O'Callaghan, M. W., Pascoe, J. R., Tyler, W. S. and Mason, D. K. (1987b) Exercise-induced pulmonary haemorrhage in the horse: results of a detailed clinical, post mortem and imaging study. VIII. Conclusions and implications. Equine vet. J. 19, 428-434.
35. Oikawa, M. (1999) Exercise-induced haemorrhagic lesions in the dorsocaudal extremities of the caudal lobes of the lungs of young thoroughbred horses. J. comp. Pathol. 121, 339-347.
36. Padilla, D. J., McDonough, P., Kindig, C. A., Erickson, H. H. and Poole, D. C. (2004) Ventilatory dynamics and control of blood gases after maximal exercise in the Thoroughbred horse. J. appl. Physiol. 96, 2187-2193.
37. Poole, D. C., Kindig, C. A. and Fenton, G. (2000) Effects of external nasal support on pulmonary gas exchange and EIPH in the horse. J. equine vet. Sci. 20, 578-585.
38. Robinson, N. E. and Derksen, F. J. (1980) Small airway obstruction as a cause of exercise-associated pulmonary haemorrhage: a hypothesis. Proc. Am. Ass. equine Practnrs. 26, 421-430.
39. Sweeney, C. R. and Soma, L. R. (1983) Exercise-induced pulmonary haemorrhage in horses after different competitive exercises. In: Equine Exercise Physiology, Eds: D. H. Snow, S. G. B. Persson and R. J. Rose, Granta Editions, Cambridge, UK. pp 51-56.
40. Valdez, S. C., Nieto, J. E., Spier, SJ., Owens, S. D., Beldomenico, P. and Snyder, J. R. (2004) Effect of an external nasal dilator strip on cytologic characteristics of bronchoalveolar lavage fluid in Thoroughbred racehorses. J. Am. vet. med. Ass. 224, 558-61.
41. West, J. B., Mathieu-Costello, O., Jones, J. H., Birks, E. K., Logemann, R. B., Pascoe, J. R. and Tyler, W. S. (1993) Stress failure of pulmonary capillaries in racehorses with exercise-induced pulmonary haemorrhage. J. appl. Physiol. 75, 1097-1109.