Inclined running increases pulmonary haemorrhage in the Thoroughbred horse

Equine Veterinary Journal

Volumn 35, Issue 6, 2003, Pages 581-585

  Kindig, C A ^a,b   Ramsel, C ^a   McDonough, P ^a   Poole, D C ^a   Erickson, H H ^a  

^a KANSAS STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Bronchoalveolar lavage; Exercise induced pulmonary haemorrhage; Horse; Pulmonary arterial pressure

Indexed keywords

LACTIC ACID;

ANIMAL EXPERIMENT; ARTERIAL GAS; ARTICLE; BREATHING; BREED; CONTROLLED STUDY; ERYTHROCYTE; EXERCISE; FATIGUE; HORSE; LACTATE BLOOD LEVEL; LUNG HEMORRHAGE; LUNG LAVAGE; LUNG MINUTE VOLUME; LUNG PRESSURE; LUNG VOLUME; MALE; NONHUMAN; RUNNING; TIDAL VOLUME; TIME; TREADMILL; ANIMAL; ANIMAL DISEASE; BLEEDING; HORSE DISEASE; LUNG CIRCULATION; LUNG DISEASE; LUNG WEDGE PRESSURE; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION;

ANIMALIA; EQUIDAE; EQUUS CABALLUS;

ANIMALS; HEMORRHAGE; HORSE DISEASES; HORSES; LUNG DISEASES; MALE; PHYSICAL CONDITIONING, ANIMAL; PULMONARY CIRCULATION; PULMONARY WEDGE PRESSURE; RANDOM ALLOCATION;

EID: 1542708848     PISSN: 04251644     EISSN: None     Source Type: Journal    
DOI: 10.2746/042516403775467199     Document Type: Article

References (26)

1. Art, T., Anderson, L., Woakes, A.J., Roberts, C., Butler, P.J., Snow, D.H. and Lekeux, P. (1990) Mechanics of breathing during strenuous exercise in Thoroughbred horses. Respir. Physiol. 82, 279-294.
2. Birks, E.K., Mathieu-Costello, O., Fu, Z., Tyler, W.S. and West, J.B. (1994) Comparative aspects of the strength of pulmonary capillaries in rabbit, dog, and horse. Respir. Physiol. 97, 235-246.
3. Birks, E.K., Mathieu-Costello, O., Fu, Z., Tyler, W.S. and West, J.B. (1997) Very high pressures are required to cause stress failure of pulmonary capillaries in thoroughbred racehorses. J. appl. Physiol. 82, 1584-1592.
4. Cook, W.R., Williams, R.M., Kirker-Head, C.A. and Verbridge, D.J. (1988) Upper airway obstruction (partial asphyxia) as the possible cause of exercise-induced pulmonary haemorrhage: an hypothesis. J. equine vet. Sci. 8, 11-26.
5. Derksen, F.J. and Robinson, N.B. (1980) Esophageal and intrapleural pressures in the healthy conscious pony. Am. J. vet. Res. 41, 1756-1761.
6. Ducharme, N.G., Hackett, R.P., Gleed, R.D., Ainsworth, D.M., Erb, H.N., Mitchell, L.M. and Soderholm, L.V. (1999) Pulmonary capillary pressure in horses undergoing alteration of pleural pressure by imposition of various upper airway resistive loads. Equine vet. J., Suppl. 30, 27-33.
7. Fedde, M.R. (1991) Blood gas analyses on equine blood: required correction factors. Equine vet. J. 23, 410-412.
8. Fu, Z., Costello, M.L., Tsukimoto, K., Prediletto, R., Elliot, A.R., Mathieu-Costello, O. and West, J.B. (1992) High lung volume increases stress failure in pulmonary capillaries. J. appl. Physiol. 73, 123-133.
9. Hinchcliff, K.W. (1999) Effects of frusemide on athletic performance and exercise-induced pulmonary haemorrhage in horses. J. Am. vet. med. Ass. 215, 630-635.
10. Holcombe, S.J., Breney, C., Cornelisse, C.J., Derksen, F.J. and Robinson, N.B. (2002) Effect of commercially available nasal strips on airway resistance in exercising horses. Am. J. vet. Res. 63, 1101-1105.
11. Kindig, C.A., McDonough, P., Fenton, G., Poole, D.C. and Erickson, H.H. (2001a) Efficacy of nasal strip and frusemide in mitigating exercise-induced pulmonary haemorrhage in thoroughbred horses. J. appl. Physiol. 91, 1396-1400.
12. Kindig, C.A., McDonough, P., Finley, M.R., Behnke, B.J., Richardson, T.E., Marlin, D.J., Erickson, H.H. and Poole, D.C. (2001b) Nitric oxide inhalation reduces pulmonary arterial pressure but not haemorrhage in maximally exercising horses. J. appl. Physiol. 91, 2674-2678.
13. Manohar, M. (1993) Frusemide attenuates the exercise-induced increase in pulmonary artery wedge pressure in horses. Am. J. vet. Res. 54, 952-958.
14. Mason, D.K., Collins, E.A. and Watkins, K.L. (1983) Exercise-induced pulmonary haemorrhage in horses. In: Equine Exercise Physiology, Granta Editions, Cambridge. pp 57-63.
15. McKane, S. and Rose, R.J. (1993) Radiographce determination of the location of a blindly passed bronchoalveolar lavage catheter. Equine vet. Educ. 5, 329-332.
16. Meyer, T.S., Fedde, M.R., Gaughan, E.M., Langsetmo, I. and Erickson, H.H. (1998) Quantification of exercise-induced pulmonary haemorrhage with bronchoalveolar lavage. Equine vet. J. 30, 284-288.
17. O'Callaghan, M.W., Pascoe, J.R., Tyler, W.S. and Mason, D.K. (1987) Exercise-induced pulmonary haemorrhage in the horse: results of a detailed clinical, post mortem and imaging study. III. Subgross findings in lungs subjected to latex perfusions of the bronchial and pulmonary arteries. Equine vet. J. 19, 394-404.
18. Olsen, S.C., Coyne, C.P., Lowe, B.S., Pelletier, N., Raub, E.M. and Erickson, H.H. (1992) Influence of frusemide on hemodynamic responses during exercise in horses. Am. J. vet. Res. 53, 742-747.
19. Pascoe, J.R., McCabe, A.E., Franti, C.E. and Arthur, R.M. (1985) Efficacy of frusemide in the treatment of exercise-induced pulmonary haemorrhage in Thoroughbred racehorses. Am. J. vet. Res. 46, 2000-2003.
20. 2 in exercising horses. Respir. Physiol. 91, 83-97.
21. Poole, D.C., Kindig, C.A., Fenton, G., Ferguson, L., Rush, B.R. and Erickson, H.H. (2000) Effects of external nasal support on pulmonary gas exchange and EIPH in the horse. J. equine vet. Sci. 20, 578-585.
22. Robinson, N.B. and Derksen, F.J. (1980) Small airway obstruction as a cause of exercise-associated pulmonary haemorrhage: an hypothesis. Proc. Am. Ass. equine Practnrs. 26, 421-430.
23. Sinha, A.K., Gleed, R.D., Hakim, T.S., Dobson, A. and Shannon, K.J. (1996) Pulmonary capillary pressure during exercise in horses. J. appl. Physiol. 80, 1792-1798.
24. West, J.B. and Mathieu-Costello, O. (1994) Stress failure of pulmonary capillaries as a mechanism for exercise induced pulmonary haemorrhage in the horse. Equine vet. J. 26, 441-447.
25. West, J.B., Mathieu-Costello, O., Jones, J.H., Birks, E.K., Logemann, R.B., Pascoe, J.R. and Tyler, W.S. (1993) Stress failure of pulmonary capillaries in racehorses with exercise-induced pulmonary haemorrhage. J. appl. Physiol. 75, 1097-1109.
26. Woakes, A.J., Butler, P.J. and Snow, D.H. (1986) The measurement of respiratory airflow in exercising horses. In: Equine Exercise Physiology, Granta Editions, Cambridge. pp 194-205.