Effect of prolonged heavy exercise on pulmonary gas exchange in horses

Journal of Applied Physiology

Volumn 84, Issue 5, 1998, Pages 1723-1730

  Hopkins, S R ^a,d   Bayly, W M ^b   Slocombe, R F ^c   Wagner, H ^a   Wagner, P D ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Intrapulmonary gas mixing; Pulmonary mechanics; Ventilation perfusion inequality

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DYNAMIC EXERCISE; EXERCISE; FEMALE; GAS MIXING; LUNG GAS EXCHANGE; LUNG MECHANICS; LUNG VENTILATION PERFUSION RATIO; MALE; NONHUMAN; PRIORITY JOURNAL;

EID: 0031958618     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1998.84.5.1723     Document Type: Article

References (34)

1. Bayly, W., H. Schott II, and R. Slocombe. Ventilatory responses of horses to prolonged submaximal exercise. Equine Vet. J. Suppl. 18: S23-S28, 1995.
2. Bayly, W. M., D. A. Schultz, D. R. Hodgson, and P. D. Gollnick. Ventilatory responses of the horse to exercise: effect of gas collection systems. J. Appl. Physiol. 63: 1210-1217, 1987.
3. Dempsey, J. A., P. G. Hanson, and K. S. Henderson. Exercised-induced arterial hypoxaemia in healthy human subjects at sea level. J. Physiol. (Lond.) 355: 161-175, 1984.
4. Downs, D., and P. D. Wagner. Detectability of diffusion-limited gas mixing by steady-state inert gas exchange (Abstract). Federation Proc. 41: 4102, 1983.
5. Gale, G. E., J. R. Torre-Bueno, R. E. Moon, H. A. Saltzman, and P. D. Wagner. Ventilation-perfusion inequality in normal humans during exercise at sea level and simulated altitude. J. Appl. Physiol. 58: 978-988, 1985.
6. Hammond, M. D., G. E. Gale, S. Kapitan, A. Ries, and P. D. Wagner. Pulmonary gas exchange in humans during exercise at sea level. J. Appl. Physiol. 60: 1590-1598, 1986.
7. Hlastala, M. P., P. Scheid, and J. Piiper. Interpretation of inert gas retention and excretion in the presence of stratified inhomogeneity. Respir. Physiol. 46: 247-259, 1981.
8. Hopkins, S. R., J. W. Hicks, T. K. Cooper, and F. L. Powell. Ventilation and pulmonary gas exchange during exercise in the Savannah Monitor Lizard (Varanus exanthematicus). J. Exp. Biol. 198: 1783-1789, 1995.
9. Hopkins, S. R., D. C. McKenzie, R. B. Schoene, R. Glenny, and H. T. Robertson. Pulmonary gas exchange during exercise in athletes. I: Ventilation-perfusion mismatch and diffusion limitation. J. Appl. Physiol. 77: 912-917, 1994.
10. Hsia, C. C., L. F. Herazo, M. Ramanathan, R. J. Johnson, and P. D. Wagner. Cardiopulmonary adaptations to pneumonectomy in dogs. II. V̇A/Q̇ relationships and microvascular recruitment. J. Appl. Physiol. 74: 1299-1309, 1993.
11. Hultgren, H. N. Pulmonary hypertension and pulmonary edema. In: Oxygen Transport to Human Tissues, edited by J. A. Loeppsky and M. L. Reidsel. New York: Elsevier/North-Holland, 1982, p. 243-254.
12. Olson, L. E. Mechanical properties of small airways in excised pony lungs. J. Appl. Physiol. 73: 522-529, 1992.
13. Paiva, M., and L. A. Engel. Pulmonary interdependence of gas transport. J. Appl. Physiol. 47: 296-305, 1979.
14. Persson, S. On blood volume and working capacity in horses. Studies of methodology and physiological and pathological variations. Acta Vet. Scand. 19, Suppl. 9: 1-189, 1967.
15. Podolsky, A., M. W. Eldridge, R. S. Richardson, D. R. Knight, E. C. Johnson, S. R. Hopkins, D. H. Johnson, H. Michimata, B. Grassi, J. Feiner, S. S. Kurdak, P. E. Bickler, J. W. Severinghaus, and P. D. Wagner. Exercise-induced V̇A/Q̇ inequality in subjects with prior high-altitude pulmonary edema. J. Appl. Physiol. 81: 922-932, 1996.
16. Powell, F. L., and A. T. Gray. Ventilation-perfusion relationships in alligators. Respir. Physiol. 78: 83-94, 1989.
17. Powell, F. L., and P. D. Wagner. Measurement of continuous distributions of ventilation-perfusion in non-alveolar lungs. Respir. Physiol. 48: 219-232, 1982.
18. Rose, R. J., J. R. Allen, K. A. Brock, C. R. Clark, D. R. Hodgson, and J. H. Stewart. Effects of clenbuterol hydrochloride on certain respiratory and cardiovascular parameters in horses performing treadmill exercise. Res. Vet. Sci. 35: 301-305, 1983.
19. 2 in the horse and comparison of five methods for determination of maximal oxygen uptake. Equine Vet. J. Suppl. 9: 39-42, 1990.
20. Schaffartzik, W., J. Arcos, K. Tsukimoto, O. Mathieu-Costello, and P. D. Wagner. Pulmonary interstitial edema in the pig after heavy exercise. J. Appl. Physiol. 75: 2535-2540, 1993.
21. Schaffartzik, W., D. C. Poole, T. Derion, K. Tsukimoto, M. C. Hogan, J. P. Arcos, D. E. Bebout, and P. D. Wagner. V̇A/Q̇ distribution during heavy exercise and recovery in humans: implications for pulmonary edema. J. Appl. Physiol. 72: 1657-1667, 1992.
22. Scheid, P., M. P. Hlastala, and J. Piiper. Inert gas elimination from lungs with stratified inhomogeneity: theory. Respir. Physiol. 44: 299-309, 1981.
23. Slocombe, R. F., G. Covelli, and W. M. Bayly. Respiratory mechanics of horses during stepwise treadmill exercise tests, and the effect of clenbuterol pretreatment on them. Aust. Vet. J. 69: 221-225, 1992.
24. Sorenson, P. R., and N. E. Robinson. Postural effects on lung volumes and asynchronous ventilation in anesthetized horses. J. Appl. Physiol. 48: 97-103, 1980.
25. Torre-Bueno, J. R., P. D. Wagner, H. A. Saltzman, G. E. Gale, and R. E. Moon. Diffusion limitation in normal humans during exercise at sea level and simulated altitude. J. Appl. Physiol. 58: 989-995, 1985.
26. Truog, W. E., M. P. Hlastala, T. A. Standaert, H. P. McKenna, and W. A. Hodson. Oxygen-induced alteration of ventilation-perfusion relationships in rats. J. Appl. Physiol. 47: 1112-1117, 1979.
27. Tsukimoto, K., J. P. Arcos, W. Schaffartzik, P. D. Wagner, and J. B. West. Effect of common dead space on V̇A/Q̇ distribution in the dog. J. Appl. Physiol. 68: 2488-2493, 1990.
28. Wagner, P. D. A general approach to the evaluation of ventilation-perfusion ratios in normal and abnormal lungs. Physiologist 20: 18-25, 1977.
29. Wagner, P. D., B. K. Erickson, K. Kubo, A. Hiraga, M. Kai, Y. Yamaya, R. Richardson, and J. Seaman. Maximum oxygen transportation and utilization before and after splenectomy. Equine Vet. J. Suppl. 18: S82-S89, 1995.
30. Wagner, P. D., J. R. Gillespie, G. L. Landgren, M. R. Fedde, B. W. Jones, R. M. de Bowes, R. L. Peischel, and H. H. Erickson. Mechanism of exercise-induced hypoxemia in horses. J. Appl. Physiol. 66: 1227-1233, 1989.
31. Wagner, P. D., P. F. Naumann, and R. B. Laravuso. Simultaneous measurement of eight foreign gases in blood by gas chromotography. J. Appl. Physiol. 36: 600-605, 1974.
32. Wagner, P. D., H. A. Saltzman, and J. B. West. Measurement of continuous distributions of ventilation-perfusion ratios: theory. J. Appl. Physiol. 36: 588-599, 1974.
33. Wagner, P. D., J. R. Sutton, J. T. Reeves, A. Cymerman, B. M. Groves, and M. K. Malconian. Operation Everest II: pulmonary gas exchange during a simulated ascent of Mt. Everest. J. Appl. Physiol. 63: 2348-2359, 1987.
34. West, J. B., O. Mathieu-Costello, J. H. Jones, E. K. Birks, R. B. Logemann, J. R. Pascoe, and W. S. Tyler. Stress failure of pulmonary capillaries in racehorses with exercise-induced pulmonary hemorrhage. J. Appl. Physiol. 75: 1097-109, 1993.