The effects and mechanism of ginsenoside Rg1 on myocardial remodeling in an animal model of chronic thromboembolic pulmonary hypertension

European Journal of Medical Research

Volumn 18, Issue 1, 2013, Pages

  Li, Chang Yi ^a   Deng, Wang ^a   Liao, Xiu Qing ^b   Deng, Jia ^a   Zhang, Yu Kun ^a   Wang, Dao Xin ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b Chongqing Fuling Central Hospital   (China)

Author keywords

Chronicthromboembolic pulmonary hypertension; Ginsenoside Rg1; Matrix metalloproteinases; Myocardial remodeling; Panax notoginseng saponins

Indexed keywords

GELATINASE A; GELATINASE B; GINSENOSIDE RG 1; GINSENOSIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FIBROSIS; HEART LEFT VENTRICLE; HEART RIGHT VENTRICLE; JUGULAR VEIN; MALE; MICROSCOPY; NONHUMAN; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING; ANIMAL; CHEMISTRY; DISEASE MODEL; GENE EXPRESSION REGULATION; HEART VENTRICLE; HEART VENTRICLE REMODELING; HUMAN; LUNG EMBOLISM; METABOLISM; PANAX NOTOGINSENG; PATHOPHYSIOLOGY; PULMONARY HYPERTENSION;

ANIMALS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GINSENOSIDES; HEART VENTRICLES; HUMANS; HYPERTENSION, PULMONARY; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; PANAX NOTOGINSENG; PULMONARY EMBOLISM; RATS; VENTRICULAR REMODELING;

EID: 84878440976     PISSN: 09492321     EISSN: 2047783X     Source Type: Journal    
DOI: 10.1186/2047-783X-18-16     Document Type: Article

References (22)

1. Beta-estradiol attenuates hypoxic pulmonary hypertension by stabilizing the expression of p27kip1 in rats. Xu DQ, Luo Y, Liu Y, Wang J, Zhang B, Xu M, Respir Res 2010 24 182 187
2. Peripheral arterial stiffness and endothelial dysfunction in idiopathic and scleroderma associated pulmonary arterial hypertension. Peled N, Shitrit D, Fox BD, Shlomi D, Amital A, Bendayan D, J Rheumatol 2009 36 970 975 10.3899/jrheum.081088 19369472
3. Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function. Spinale FG, Physiol Rev 2007 87 1285 1342 10.1152/physrev.00012.2007 17928585
4. Pharmacological activity of sanchi ginseng (Panax notoginseng). Ng TB, J Pharm Pharmacol 2006 58 1007 1019 10.1211/jpp.58.8.0001 16872547
5. High performance liquid chromatographic assay for the active saponins from Panax notoginseng in rat tissues. Li L, Sheng YX, Zhang JL, Wang SS, Guo DA, Biomed Chromatogr 2006 20 327 335 10.1002/bmc.567 16138297
6. Haemolytic activity and immunological adjuvant effect of Panax notoginseng saponins. Sun HX, Pan HJ, Pan YJ, Acta Pharmaceutica Sinica 2003 24 1150 1154
7. Total saponins of Panax notoginseng protect rabbit iliac artery against balloon endothelial denudation injury. Chen SW, Li XH, Ye KH, Jiang ZF, Ren XD, Acta Pharmaceutica Sinica 2004 25 1151 1156
8. Phytochemical and analytical studies of Panax notoginseng (Burk.). Wang CZ, McEntee E, Wicks S, Wu JA, Yuan CS, J Nat Med 2006 60 97 106 10.1007/s11418-005-0027-x
9. A trace component of ginseng that inhibit Ca2+ channels through a pertussis toxin-sensitive G protein. Nah SY, Park HJ, McClesky EW, Proc Natl Acad Sci USA 1995 92 8739 8743 10.1073/pnas.92.19.8739 7568008
10. Pharmacokinetics and bioavailability of ginsenoside Rb1 and Rg1 from Panax notoginseng in rats. Xu QH, Fang XL, Chen DF, J Ethnopharmacol 2003 84 187 192 10.1016/S0378-8741(02)00317-3 12648814
11. Effect of total saponins of 'Panax notoginseng root' on aortic intimal hyperplasia and the expressions of cell cycle protein and extracellular matrix in rats. Wu L, Zhang W, Tang YH, Li H, Chen BY, Zhang GM, Phytomedicine 2010 17 233 240 10.1016/j.phymed.2009.07.021 19748258
12. Gelatin microspheres encapsulated with a nonpeptide angiogenic agent, ginsenoside Rg1, for intramyocardial injection in a rat model with infarcted myocardium. Wei HJ, Yang HH, Chen CH, Lin WW, Chen SC, Lai PH, J Control Rel 2007 120 27 34 10.1016/j.jconrel.2007.04.005
13. Effects of Panax notoginseng saponins on the expression of tumor necrosis factor alpha and secretion phospholipase A2 in rats with liver fibrosis. Wu F, Zhang SS, Kang GF, Zhong hua Gan Zang Bing Za Zhi 2003 11 51 52 (in Chinese)
14. Chronic pulmonary thromboembolism in dogs treated with tranexamic acid. Moser KM, Cantor JP, Olman M, Villespin I, Graif JL, Konopka R, Circulation 1991 83 1371 1379 10.1161/01.CIR.83.4.1371 2013154
15. The collagen matrix of the heart. Borg TK, Caulfield JB, Fed Proc 1981 40 2037 2041 7227559
16. Non-fibrillar collagens: key mediators of post-infarction cardiac remodeling. Shamhart PE, Meszaros JG, Mol Cell Cardiol 2010 48 530 537 10.1016/j.yjmcc.2009.06.017
17. Myocardial remodeling afterinfarction: the role of myofibroblasts. van den Borne SW, Diez J, Blankesteijn WM, Verjans J, Hofstra L, Narula J, Nat Rev Cardiol 2010 7 30 37 10.1038/nrcardio.2009.199 19949426
18. Hypothermia and postconditioning after cardiopulmonary resuscitation reduce cardiac dysfunction by modulating inflammation, apoptosis and remodeling. Meybohm P, Gruenewald M, Albrecht M, Zacharowski KD, Lucius R, Zitta K, Koch A, Tran N, Scholz J, Bein B, PLoS One 2009 4 7588 10.1371/journal.pone.0007588 19855846
19. Effects of telmisartan on markers of ventricular remodeling in patients with acute myocardial infarction: comparison with enalapril. Yokota T, Osanai T, Hanada K, Kushibiki M, Abe N, Oikawa K, Hear Vessel 2010 25 460 468 10.1007/s00380-010-0013-4
20. Cardiac remodeling and MMPs on the model of chronic daunorubicin-induced cardiomyopathy in rabbits. Adamcová M, Potáčová A, Popelová O, Stěrba M, Mazurová Y, Aupperle H, Physiol Res 2010 59 831 836 20406046
21. Extracellular matrix metalloproteinase inducer (EMMPRIN) is increased in human left ventricle after acute myocardial infarction. Nie R, Xie S, Du B, Liu X, Deng B, Wang J, Arch Med Res 2009 40 605 611 10.1016/j.arcmed.2009.09.001 20082877
22. Reverse remodeling of the myocardial extracellular matrix after prolonged left ventricular assist device support follows a biphasic pattern. Bruggink AH, van Oosterhout MF, de Jonge N, Ivangh B, van Kuik J, Voorbij RH, J Heart Lung Transplant 2006 25 1091 1098 10.1016/j.healun.2006.05.011 16962471