Explant cultures of Rpe65-/- mouse retina: A model to investigate cone opsin trafficking

Molecular Vision

Volumn 19, Issue , 2013, Pages 1149-1157

  Bandyopadhyay, Mausumi ^a   Kono, Masahiro ^a   Rohrer, Bärbel ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b RALPH H JOHNSON VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

11 CIS RETINAL; CONE OPSIN; MESSENGER RNA; RETINAL PIGMENT EPITHELIUM SPECIFIC PROTEIN 65; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR; RHODOPSIN; TRANSDUCIN; UNCLASSIFIED DRUG; VISUAL PROTEINS AND PIGMENTS;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXPLANT; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; ORGAN CULTURE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; RETINA;

ANIMALS; CIS-TRANS-ISOMERASES; CONE OPSINS; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; MOLECULAR WEIGHT; ORGAN CULTURE TECHNIQUES; ORGAN SPECIFICITY; PHENOTYPE; PROTEIN TRANSPORT; RETINA; RETINAL PIGMENT EPITHELIUM; RETINALDEHYDE; RHODOPSIN; TRETINOIN; ULTRAVIOLET RAYS; VITAMIN A;

EID: 84878433494     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Young RW. Cell death during differentiation of the retina in the mouse. J Comp Neurol 1984; 229:362-373. [PMID: 6501608].
2. Rich KA, Zhan Y, Blanks JC. Migration and synaptogenesis of cone photoreceptors in the developing mouse retina. J Comp Neurol 1997; 388:47-63. [PMID: 9364238].
3. Bumsted K, Jasoni C, Szel A, Hendrickson A. Spatial and temporal expression of cone opsins during monkey retinal development. J Comp Neurol 1997; 378:117-134. [PMID: 9120 051].
4. Xiao M, Hendrickson A. Spatial and temporal expression of short, long/medium, or both opsins in human fetal cones. J Comp Neurol 2000; 425:545-559. [PMID: 10975879].
5. Treisman JE, Morabito MA, Barnstable CJ. Opsin expression in the rat retina is developmentally regulated by transcriptional activation. Mol Cell Biol 1988; 8:1570-1579. [PMID: 29 67911].
6. Fei Y. Development of the cone photoreceptor mosaic in the mouse retina revealed by fluorescent cones in transgenic mice. Mol Vis 2003; 9:31-42. [PMID: 12592228].
7. Applebury ML, Antoch MP, Baxter LC, Chun LL, Falk JD, Farhangfar F, Kage K, Krzystolik MG, Lyass LA, Robbins JT. The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning. Neuron 2000; 27:513-523. [PMID: 11055434].
8. Lyubarsky AL, Falsini B, Pennesi ME, Valentini P, Pugh EN. UV- and midwave-sensitive cone-driven retinal responses of the mouse: a possible phenotype for coexpression of cone photopigments. J Neurosci 1999; 19:442-455. [PMID: 9870972].
9. Jacobs GH, Neitz J, Deegan JF. Retinal receptors in rodents maximally sensitive to ultraviolet light. Nature 1991; 353:655-656. [PMID: 1922382].
10. Jeon CJ, Strettoi E, Masland RH. The major cell populations of the mouse retina. J Neurosci 1998; 18:8936-8946. [PMID: 9786999].
11. Deretic D. A role for rhodopsin in a signal transduction cascade that regulates membrane trafficking and photoreceptor polarity. Vision Res 2006; 46:4427-4433. [PMID: 17010408].
12. Karan S, Zhang H, Li S, Frederick JM, Baehr W. A model for transport of membrane-associated phototransduction polypeptides in rod and cone photoreceptor inner segments. Vision Res 2008; 48:442-452. [PMID: 17949773].
13. Sung CH, Tai AW. Rhodopsin trafficking and its role in retinal dystrophies. Int Rev Cytol 2000; 195:215-267. [PMID: 10603577].
14. Carroll J, Baraas RC, Wagner-Schuman M, Rha J, Siebe CA, Sloan C, Tait DM, Thompson S, Morgan JI, Neitz J, Williams DR, Foster DH, Neitz M. Cone photoreceptor mosaic disruption associated with Cys203Arg mutation in the M-cone opsin. Proc Natl Acad Sci USA 2009; 106:20948-20953. [PMID: 19934058].
15. -/-mice: a defect that can be corrected by 11-cis retinal. Invest Ophthalmol Vis Sci 2005; 46:3876-3882. [PMID: 16186377].
16. Pang J, Boye SE, Lei B, Boye SL, Everhart D, Ryals R, Umino Y, Rohrer B, Alexander J, Li J, Dai X, Li Q, Chang B, Barlow R, Hauswirth WW. Self-complementary AAV-mediated gene therapy restores cone function and prevents cone degeneration in two models of Rpe65 deficiency. Gene Ther 2010; 17: 815-826. [PMID: 2 0 2 37510].
17. Carter-Dawson L, Alvarez RA, Fong SL, Liou GI, Sperling HG, Bridges CD. Rhodopsin, 11-cis vitamin A, and interstitial retinol-binding protein (IRBP) during retinal development in normal and rd mutant mice. Dev Biol 1986; 116:431-438. [PMID: 3732615].
18. Noorwez SM, Malhotra R, McDowell JH, Smith KA, Krebs M P, Kaushal S. Retinoids assist the cellular folding of the autosomal dominant retinitis pigmentosa opsin mutant P23H. J Biol Chem 2004; 279:16278-16284. [PMID: 14769795].
19. Mendes HF, Cheetham ME. Pharmacological manipulation of gain-of-function and dominant-negative mechanisms in rhodopsin retinitis pigmentosa. Hum Mol Genet 2008; 17: 3043-3054. [PMID: 18 6355 76].
20. Ohgane K, Dodo K, Hashimoto Y. Retinobenzaldehydes as proper-trafficking inducers of folding-defective P23H rhodopsin mutant responsible for retinitis pigmentosa. Bioorg Med Chem 2010; 18:7022-7028. [PMID: 20805032].
21. Mendes HF, Zaccarini R, Cheetham ME. Pharmacological manipulation of rhodopsin retinitis pigmentosa. Adv Exp Med Biol 2010; 664:317-323. [PMID: 2 0 238031].
22. Noorwez SM, Ostrov DA, McDowell JH, Krebs MP, Kaushal S. A high-throughput screening method for small-molecule pharmacologic chaperones of misfolded rhodopsin. Invest Ophthalmol Vis Sci 2008; 49:3224-3230. [PMID: 18378578].
23. Kono M, Crouch RK. In vitro assays of rod and cone opsin activity: retinoid analogs as agonists and inverse agonists. Methods Mol Biol 2010; 652:85-94. [PMID: 20552423].
24. Kono M, Crouch RK. Probing human red cone opsin activity with retinal analogues. J Nat Prod 2011; 74:391-394. [PMID: 21 31410 0].
25. Ala-Laurila P, Cornwall MC, Crouch RK, Kono M. The action of 11-cis-retinol on cone opsins and intact cone photoreceptors. J Biol Chem 2009; 284:16492-16500. [PMID: 19386593].
26. Rohrer B, Ogilvie JM. Retarded outer segment development in TrkB knockout mouse retina organ culture. Mol Vis 2003; 9:18-23. [PMID: 12552255].
27. Ogilvie JM, Speck JD, Lett JM, Fleming TT. A reliable method for organ culture of neonatal mouse retina with long- term survival. J Neurosci Methods 1999; 87:57-65. [PMID: 10065994].
28. Bandyopadhyay M, Rohrer B. Photoreceptor structure and function is maintained in organotypic cultures of mouse retinas. Mol Vis 2010; 16:1178-1185. [PMID: 20664685].
29. Ogilvie JM, Speck JD, Lett JM. Growth factors in combination, but not individually, rescue rd mouse photoreceptors in organ culture. Exp Neurol 2000; 161:676-685. [PMID: 10686086].
30. Pinzón-Duarte G, Kohler K, Arango-Gonzalez B, Guenther E. Cell differentiation, synaptogenesis, and influence of the retinal pigment epithelium in a rat neonatal organotypic retina culture. Vision Res 2000; 40:3455-3465. [PMID: 11115 6 7 2].
31. Kawamorita M, Suzuki C, Saito G, Sato T, Sato K. In vitro differentiation of mouse embryonic stem cells after activation by retinoic acid. Hum Cell 2002; 15:178-182. [PMID: 12703548].
32. Dawson MI, Zhang XK. Discovery and design of retinoic acid receptor and retinoid X receptor class- and subtype-selective synthetic analogs of all-trans-retinoic acid and 9-cis-retinoic acid. Curr Med Chem 2002; 9:623-637. [PMID: 11945128].
33. Rohrer B, Korenbrot JI, LaVail MM, Reichardt LF, Xu B. Role of neurotrophin receptor TrkB in the maturation of rod photoreceptors and establishment of synaptic transmission to the inner retina. J Neurosci 1999; 19:8919-8930. [PMID: 10 516 311].
34. Rohrer B, LaVail MM, Jones KR, Reichardt LF. Neurotrophin receptor TrkB activation is not required for the postnatal survival of retinal ganglion cells in vivo. Exp Neurol 2001; 172: 81-91. [PMID: 116 818 4 2].
35. Rohrer B, Pinto FR, Hulse KE, Lohr HR, Zhang L, Almeida JS. Multidestructive pathways triggered in photoreceptor cell death of the rd mouse as determined through gene expression profiling. J Biol Chem 2004; 279:41903-41910. [PMID: 15218 0 2 4].
36. Molday RS, MacKenzie D. Monoclonal antibodies to rhodopsin: characterization, cross-reactivity, and application as structural probes. Biochemistry 1983; 22:653-660. [PMID: 6188 482].
37. Franke RR, Sakmar TP, Oprian DD, Khorana HG. A single amino acid substitution in rhodopsin (lysine 248--leucine) prevents activation of transducin. J Biol Chem 1988; 263:2119-2122. [PMID: 31234 8 7].
38. Oprian DD. Expression of opsin genes in COS cells. Methods in Neurosci 1993; 15:301-306.
39. Robinson PR. Assays for detection of constitutively active opsins. Methods Enzymol 2000; 315:207-218. [PMID: 10736704].
40. Kono M. Assays for inverse agonists in the visual system. Methods Enzymol 2010; 485:213-224. [PMID: 21050919].
41. Wessling-Resnick M, Johnson GL. Transducin interactions with rhodopsin. Evidence for positive cooperative behavior. J Biol Chem 1987; 262:12444-12447. [PMID: 31142 58].
42. Baehr W, Morita EA, Swanson RJ, Applebury ML. Characterization of bovine rod outer segment G-protein. J Biol Chem 1982; 257:6452-6460. [PMID: 7076677].
43. -/- Mice: Comparable models of Leber congenital amaurosis. Invest Ophthalmol Vis Sci 2008; 49:2384-2389. [PMID: 18296659].
44. Zhang H, Fan J, Li S, Karan S, Rohrer B, Palczewski K, Frederick JM, Crouch RK, Baehr W. Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinal. J Neurosci 2008; 28: 4008-4014. [PMID: 18400900].
45. Kunchithapautham K, Coughlin B, Crouch RK, Rohrer B. Cone outer segment morphology and cone function in the Rpe65-/- Nrl-/- mouse retina are amenable to retinoid replacement. Invest Ophthalmol Vis Sci 2009; 50:4858-4864. [PMID: 19 4 0 7011].
46. Wang JS, Estevez ME, Cornwall MC, Kefalov VJ. Intra-retinal visual cycle required for rapid and complete cone dark adaptation. Nat Neurosci 2009; 12:295-302. [PMID: 19182795].
47. Luo T, Sakai Y, Wagner E, Drager UC. Retinoids, eye development, and maturation of visual function. J Neurobiol 2006; 66:677-686. [PMID: 16688765].
48. Weiler R, He S, Vaney DI. Retinoic acid modulates gap junctional permeability between horizontal cells of the mammalian retina. Eur J Neurosci 1999; 11:3346-3350. [PMID: 10510200].
49. Urbach J, Rando RR. Isomerization of all-trans-retinoic acid to 9-cis-retinoic acid. Biochem J 1994; 299:459-465. [PMID: 81726 07].
50. Chambon P. A decade of molecular biology of retinoic acid receptors. FASEB J 1996; 10:940-954. [PMID: 8801176].
51. Heck M, Schadel SA, Maretzki D, Hofmann K P. Secondary binding sites of retinoids in opsin: characterization and role in regeneration. Vision Res 2003; 43:3003-3010. [PMID: 14 6119 36].
52. McCaffery P, Mey J, Drager UC. Light-mediated retinoic acid production. Proc Natl Acad Sci USA 1996; 93:12570-12574. [PMID: 89 01623].
53. Napoli JL, Race KR. Microsomes convert retinol and retinal into retinoic acid and interfere in the conversions catalyzed by cytosol. Biochim Biophys Acta 1990; 1034:228-232. [PMID: 2354194].