Neurotrophin receptor TrkB activation is not required for the postnatal survival of retinal ganglion cells in vivo

Experimental Neurology

Volumn 172, Issue 1, 2001, Pages 81-91

  Rohrer, Baerbel ^a   LaVail, Matthew M ^a   Jones, Kevin R ^b   Reichardt, Louis F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Myelination; Neuroprotection; Optic nerve; Retinal ganglion cell; TrkB

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; NERVE GROWTH FACTOR; NEUROTROPHIN 4; NEUROTROPHIN RECEPTOR; PROTEIN TYROSINE KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; MOUSE; NERVE DEGENERATION; NERVE FIBER TRANSECTION; NONHUMAN; OPTIC TECTUM; OXIDATIVE STRESS; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR UPREGULATION; RETINA GANGLION CELL; SIGNAL TRANSDUCTION;

EID: 0035211625     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2001.7795     Document Type: Article

References (53)

1. Malnutrition effects on the optic nerve of adult and developing rat
2. There are different expressions of BDNF and its variants between human neuroblastomas with favorable prognoses and with unfavorable prognoses
3. Signal transduction mediated by the truncated trkB receptor isoforms, trkB.T1 and trkB.T2
4. The role of oxidative stress in the pathogenesis of age-related macular degeneration
5. Patterned expression of BDNF and NT-3 in the retina and anterior segment of the developing mammalian eye
6. Heat shock cognate-70 gene expression declines during normal aging of the primate retina
7. Morphological changes in the retina of aging rats
8. Reduced size of retinal ganglion cell axons and hypomyelination in mice lacking brain-derived neurotrophic factor
9. Potential role for BDNF and TrkB in developing topographic retinotectal projections
10. Oxidative stress and Alzheimer disease
11. Effects of brain-derived neurotrophic factor on optic axon branching and remodelling in vivo
12. Decreased expression of BDNF and trkB as a function of age and cognitive performance
13. At least two mechanisms are involved in the death of retinal ganglion cells following target ablation in neonatal rats
14. CNTF, not other trophic factors, promotes axonal regeneration of axotomized retinal ganglion cells in adult hamsters
15. Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Müller cells temporarily rescues injured retinal ganglion cells
16. Aging of the optic nerve
17. Development of cell and fiber lamination in the mouse superior colliculus
18. Development of the crossed retinocollicular projection in the mouse
19. Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling
20. Genetic evidence for cell death mediated by nerve growth factor and the neurotrophin receptor p75 in the developing mouse retina and spinal cord
21. The development of the rod photoresponse from dark-adapted rats
22. Localization of two calcium binding proteins, calbindin (28 kD) and parvalbumin (12 kD), in the vertebrate retina
23. Immunocytochemical analysis of the mouse retina
24. Expression of Trk receptors in the developing mouse trigeminal ganglion: In vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkC
25. POU domain factor Brn-3a controls the differentiation and survival of trigeminal neurons by regulating Trk receptor expression
26. The major cell populations of the mouse retina
27. Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death
28. Preconditioning with bright light evokes a protective response against light damage in the rat retina
29. BDNF injected into the superior colliculus reduces developmental retinal ganglion cell death
30. Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells
31. Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo
32. Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture
33. Age-related decrease in brain-derived neurotrophic factor gene expression in the brain of the zitter rat with genetic spongiform encephalopathy
34. Roles of trkB ligands in developmental retinal ganglion cell death
35. Effects of early visual experience and diurnal rhythms on BDNF mRNA and protein levels in the visual system, hippocampus, and cerebellum
36. Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats
37. Effect of aging on the nerve fibre population of rat optic nerve
38. Role of neurotrophin receptor TrkB in the maturation of rod photoreceptors and establishment of synaptic transmission to the inner retina
39. Repetitive firing deficits in brain-derived neurotrophic factor knockout mice
40. Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons have impaired long-term spatial memory but normal hippocampal LTP
41. Intracellular signaling pathways activated by neurotrophic factors
42. Relationship of retinotopic ordering of axons in the optic pathway to the formation of visual maps in central targets
43. Localization of mRNAs for trkB isoforms and p75 in rat retinal ganglion cells
44. Neurotrophins in the developing and regenerating visual system
45. Adenovirus-mediated expression of ciliary neurotrophic factor (CNTF) rescues axotomized rat retinal ganglion cells but does not support axonal regeneration in vivo
46. Age-related retinal changes - Comparison between albino and pigmented rats
47. Natural variation in neuron number in mice is linked to a major quantitative trait locus on Chr 11
48. The role of brain-derived neurotrophic factor receptors in the mature hippocampus: Modulation of long-term potentiation through a presynaptic mechanism involving trkB
49. Cortical degeneration in the absence of neurotrophin signaling: Dendritic retraction and neuronal loss after removal of the receptor TrkB
50. Neurotrophin binding to the p75 receptor modulates Rho activity and axonal outgrowth
51. Cell death during differentiation of the retina in the mouse
52. Effects of basic fibroblast growth factor in retinal ischemia