Continuous Cold without Cryogenic Consumables: Development of a Convenient Laboratory Tool for Low-Temperature Flow Processes

Chemical Engineering and Technology

Volumn 36, Issue 6, 2013, Pages 959-967

  Browne, D L ^a   Harji, B H ^b   Ley, S V ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Brookfield Business Centre   (United Kingdom)

Author keywords

Continuous processing; Flow chemistry; Low temperature

Indexed keywords

CHEMICAL PROCESSING; CONTINUOUS FLOWS; CONTINUOUS PROCESSING; EXTENDED REACTIONS; FLOW CHEMISTRY; LABORATORY DEVICES; LOW TEMPERATURES; REACTION STABILITY;

CHEMICAL INDUSTRY; CRYOGENICS; ENERGY TRANSFER; TEMPERATURE;

SYNTHESIS (CHEMICAL);

EID: 84878431150     PISSN: 09307516     EISSN: 15214125     Source Type: Journal    
DOI: 10.1002/ceat.201200581     Document Type: Article

References (24)

1. M.D. Hopkin, I.R. Baxendale, S.V. Ley, Chem. Commun. 2010, 46, 2450.
2. Z. Qian, I.R. Baxendale, S.V. Ley, Chem. Eur. J. 2010, 16, 12342.
3. C.J. Smith, C.D. Smith, N. Nikbin, S.V. Ley, I.R. Baxendale, Org. Biomol. Chem. 2011, 9, 1927.
4. C.J. Smith, N. Nikbin, S.V. Ley, H. Lange, I.R. Baxendale, Org. Biomol. Chem. 2011, 9, 1938.
5. D.L. Browne, I.R. Baxendale, S.V. Ley, Tetrahedron 2011, 67, 10296.
6. N. Chernyak, S.L. Buchwald, J. Am. Chem. Soc. 2012, 134, 12466.
7. E. Takizawa, A. Nagaki, J. Yoshida, Tetrahedron Lett. 2012, 53, 1397.
8. C.F. Carter, H. Lange, I.R. Baxendale, S.V. Ley, J. Goode, N. Gaunt, B. Wittkamp, Org. Proc. Res. Dev. 2010, 14, 393.
9. M. O'Brien, I.R. Baxendale, S.V. Ley, Org. Lett. 2010, 12, 1596.
10. A. Polyzos, M. O'Brien, T. Pugaard-Petersen, I.R. Baxendale, S.V. Ley, Angew. Chem. Int. Ed. 2011, 50, 1190.
11. D.L. Browne, M. O'Brien, P. Koos, P.B. Cranwell, A. Polyzos, S.V. Ley, Synlett 2012, 1402.
12. D.L. Browne, B.J. Deadman, R. Ashe, I.R. Baxendale, S.V. Ley, Org. Proc. Res. Dev. 2011, 15, 693.
13. P. Koos, D.L. Browne, S.V. Ley, Green Process. Synth. 2012, 1, 11.
14. D.L. Browne, S. Wright, B.J. Deadman, S. Dunnage, I.R. Baxendale, R.M. Turner, S.V. Ley, Rapid Commun. Mass Spectrom. 2012, 26, 1999.
15. M. O'Brien, P. Koos, D.L. Browne, S.V. Ley, Org. Biomol. Chem. 2012, 10, 7031.
16. D.X. Hu, M. O'Brien, S.V. Ley, Org. Lett. 2012, 14, 4246.
17. Heating and Cooling Apparatus, UK patent GB1120379.1, International PCT/GB2012/052623, 2011.
18. Process controller available from Eurotherm. http://www.eurotherm.com/ [accessed on 30th September 2012].
19. The two refrigeration compressor setup is available from Danfoss Ltd. http://www.danfoss.com/United_Kingdom/ [accessed on 30th September 2012].
20. The miniature compressors are available from a number of suppliers for example: http://www.aspencompressor.com/ or http://www.rinitech.com/ [accessed on 30th September 2012].
21. A. A. Sathe, E. A. Groll, S. V. Garimella, Int. Compressor Engineering Conf., Purdue 2008
22. D.L. Browne, M. Baumann, B.H. Harji, I.R. Baxendale, S.V. Ley, Org. Lett. 2011, 13, 3312.
23. A. Desai, Angew. Chem., Int. Ed. 2012, 51, 9223.
24. For some examples of commercially available meso-scale flow systems see: Syrris - http://syrris.com/, Uniqsis - http://www.uniqsis.com/, Vapourtec - http://www.vapourtec.co.uk/