A Facile Hydroxyindole Carboxylic Acid Based Focused Library Approach for Potent and Selective Inhibitors of Mycobacterium Protein Tyrosine PhosphataseB

ChemMedChem

Volumn 8, Issue 6, 2013, Pages 904-908

  Zeng, Li Fan ^a   Xu, Jie ^a   He, Yantao ^a   He, Rongjun ^a   Wu, Li ^a   Gunawan, Andrea M ^a   Zhang, Zhong Yin ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amides; Focused libraries; Inhibitors; Protein tyrosine phosphatases; Tuberculosis

Indexed keywords

BACTERIAL ENZYME; CARBOXYLIC ACID; INDOLE DERIVATIVE; MYCOBACTERIUM PROTEIN TYROSINE PHOSPHATASE B; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CLICK CHEMISTRY; CYCLIZATION; ELECTROPHILICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; IODINATION; ISOMER; MOLECULAR LIBRARY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; SONOGASHIRA REACTION;

CARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; INDOLES; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PROTEIN TYROSINE PHOSPHATASES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84878375774     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201300115     Document Type: Article

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