Protein kinase B/Akt is required for complete freund's adjuvant-induced upregulation of Nav1.7 and Nav1.8 in primary sensory neurons

Journal of Pain

Volumn 14, Issue 6, 2013, Pages 638-647

  Liang, Lingli ^a   Fan, Longchang ^a,b   Tao, Bo ^c   Yaster, Myron ^a   Tao, Yuan Xiang ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Akt; dorsal root ganglion; inflammatory pain; Nav1.7; Nav1.8

Indexed keywords

FREUND ADJUVANT; PROTEIN KINASE B; SODIUM CHANNEL NAV1.7; SODIUM CHANNEL NAV1.8;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHRONIC PAIN; CONTROLLED STUDY; ENZYME ACTIVATION; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; SPINAL GANGLION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ENZYME INHIBITORS; FREUND'S ADJUVANT; GANGLIA, SPINAL; MALE; NAV1.7 VOLTAGE-GATED SODIUM CHANNEL; NAV1.8 VOLTAGE-GATED SODIUM CHANNEL; ONCOGENE PROTEIN V-AKT; PHOSPHOPYRUVATE HYDRATASE; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SENSORY RECEPTOR CELLS; SIGNAL TRANSDUCTION; TIME FACTORS; UP-REGULATION;

EID: 84878371715     PISSN: 15265900     EISSN: 15288447     Source Type: Journal    
DOI: 10.1016/j.jpain.2013.01.778     Document Type: Article

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