High NADPH/NADP+ ratio improves thymidine production by a metabolically engineered Escherichia coli strain

Journal of Biotechnology

Volumn 149, Issue 1-2, 2010, Pages 24-32

  Lee, Hyeon Cheol ^a   Kim, Jin Sook ^a   Jang, Wonhee ^b   Kim, Sang Yong ^a  

^a BioNgene Co Ltd   (South Korea)

^b Dongguk University   (South Korea)

Author keywords

NADPH NADP+ ratio; Overproduction; Pgi knockout; Thymidine; UdhA overexpression

Indexed keywords

ANTI-VIRAL DRUGS; CHEMOSTAT CULTURE; COFACTORS; FED-BATCH FERMENTATION; METABOLIC FLOW; NAD(P)H; NADPH AVAILABILITY; OVER-EXPRESSION; PHOSPHOGLUCOSE ISOMERASE; POSITIVE CORRELATIONS; REACTION EQUILIBRIUM; REAL TIME RT-PCR; REDOX BALANCES; SOLUBLE TRANSHYDROGENASE; TRANSCRIPTIONAL REGULATION; TRANSHYDROGENASES;

BIOCHEMISTRY; CHEMOSTATS; ESCHERICHIA COLI; FERMENTATION; GLUCOSE; LAWS AND LEGISLATION;

STRAIN;

CARBON; GLUCOSE; GLUCOSE 6 PHOSPHATE ISOMERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THYMIDINE;

ARTICLE; BACTERIAL STRAIN; BATCH FERMENTATION; BIOSYNTHESIS; CHEMOSTAT; CONTROLLED STUDY; ESCHERICHIA COLI; GENE; GLYCOLYSIS; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEADY STATE; TRANSCRIPTION REGULATION;

ESCHERICHIA COLI; NADP; THYMIDINE;

ESCHERICHIA COLI;

EID: 77955429093     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2010.06.011     Document Type: Article

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