Effects of mixing on fed-batch fermentation of L-ornithine

Journal of Bioscience and Bioengineering

Volumn 89, Issue 6, 2000, Pages 539-544

  Lee, Hong Woen ^a   Yoon, Sun Jun ^b   Jang, Hyung Wook ^c   Kim, Chun Sug ^a   Kim, Tae Hyo ^a   Ryu, Wuk Sang ^c   Jung, Joon Ki ^a   Park, Young Hoon ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Konkuk University   (South Korea)

^c Yang Ji Chemical Co Ltd   (South Korea)

Author keywords

Fed batch fermentation; L ornithine; Mixing effect; Scale up

Indexed keywords

AMINO ACIDS; BACTERIA; BATCH CELL CULTURE; CARBON DIOXIDE; FERMENTERS; GLUCOSE; GROWTH KINETICS; METABOLITES; OXYGEN;

BREVIBACTERIUM KETOGLUTAMICUM; FED BATCH FERMENTATION; ORNITHINE;

FERMENTATION;

ORNITHINE;

ANALYTIC METHOD; ARTICLE; AUXOTROPHY; BACTERIAL GROWTH; BIOREACTOR; BREVIBACTERIUM; CULTURE MEDIUM; FERMENTATION; NONHUMAN;

BACTERIA (MICROORGANISMS); BREVIBACTERIUM; RHODOCOCCUS ERYTHROPOLIS;

EID: 0034210933     PISSN: 13891723     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1389-1723(00)80053-5     Document Type: Article

References (22)

1. 1. Salvatore, F., Cimino, F., Maria, C., and Cittadini, D.: Mechanism of the protection by L-ornithine-L-aspartate mixture and by L-arginine in ammonia intoxication. Arch. Biochem. Biophys., 107, 499-503 (1964).
2. 2. Ruffio, P.: Amino acid products and technology, In Business Opportunity Report C-056. Business Communication Co. Inc., Norwalk, Connecticut, USA (1986).
3. 3. Kinoshita, S., Nakayama, K., and Udaka, S.: The fermentative production of L-ornithine. J. Gen. Appl. Microbiol., 3, 276-277 (1957).
4. 4. Vogel, H. J.: Path of ornithine synthesis in E. coli. Proc. Natl. Acad. Sci. USA, 39, 578-583 (1953).
5. 5. Udaka, S. and Kinoshita, S.: Studies on L-ornithine fermentation. I. The biosynthesis pathway of L-ornithine in Micrococcus glutamicus. J. Gen. Appl. Microbiol., 4, 272-282 (1958).
6. 6. Udaka, S. and Kinoshita, S.: Studies on L-ornithine fermentation. II. The change of fermentation product by a feedback type mechanism. J. Gen. Appl. Microbiol., 4, 283-288 (1958).
7. 7. Udaka, S.: Pathway specific pattern of control of arginine biosynthesis in bacteria. J. Bacteriol., 91, 617-621 (1966).
8. 8. Yoshida, H., Araki, K., and Nakayama, K.: Mechanism of L-arginine production by L-arginine-production mutants of C. glutamicum. Agric. Biol. Chem., 43, 105-111 (1979).
9. 9. Yoshida, H., Araki, K., and Nakayama, K.: N-Acetylglutamate-acetylornithine acetyltransferase-deficient arginine auxotroph of C. glutamicum. Agric. Biol. Chem., 43, 1899-1903 (1979).
10. 10. Yoshida, H., Araki, K., and Nakayama, K.: N-Acetyl-ornithine-d-aminotransferase-deficient and N-acetylglutamokinase-deficient arginine auxotrophs of C. glutamicum. Agric. Biol. Chem., 44, 361-345 (1980).
11. 11. Choi, D. K., Ryu, W. S., Chung, B. H., and Park, Y. H.: Effect of dilution rate in continuous production of L-ornithine by an auxotrophic mutant. J. Ferment. Bioeng., 80, 97-100 (1995).
12. 12. Bryant, J.: The characterization of mixing in fermentors. Adv. Biochem. Eng., 5, 101-123 (1977).
13. 13. Mayr, B., Nagy, E., Horvat, P., and Moser, A.: Modeling of mixing and stimulation of its effect on glutamic acid fermentation. Chem. Biochem. Eng., Q. 7, 31-42 (1993).
14. 14. Chinard, F. P.: Photometric estimation of proline and ornithine. J. Biol. Chem., 199, 91-95 (1952).
15. 15. Nagy, E., Neubeck, M., Mayr, B., and Moser, A.: Simulation of the effect of mixing, scale-up and pH-value regulation during glutamic acid fermentation. Bioprocess. Eng., 12, 232-238 (1995).
16. 16. Larsson, G., Törnkvist, M., Wernersson, E. S., Tragårdh, C., Noorman, H., and Enfors, S.-O.: Substrate gradients bioreactors: origin and consequence. Bioprocess Eng., 14, 281-289 (1996).
17. 17. Bylund, F., Collet, E., Enfors, S.-O., and Larsson, G.: Substrate gradient formation in the large-scale bioreactor lower cell yield and increase by-product formation. Bioprocess Eng., 18, 171-180 (1998).
18. 18. Doran, P.M.: Fluid flow and mixing, p. 129-163. In Doran, P. M. (ed.), Bioprocess engineering principles. Academic Press, London (1995).
19. 19. Kossen, N. W. F. and Oosterhuis, N. M. G.: Modeling and scaling-up of bioreactors, p. 571-560. In Rehm, H. J. and Reed, G. (ed.), Biotechnology, vol. 2. VCH, Weinheim (1985).
20. 20. Mayr, B., Horvat, P., and Moser, A.: Engineering approach to mixing quantification in bioreactors. Bioprocess. Eng., 8, 137-143 (1992).
21. 21. Shioya, S.: Optimization and control in fed-batch bioreactors. Adv. Biochem. Eng., 46, 111-142 (1992).
22. 22. Kiss, R. D. and Stephanopoulos, G.: Metabolic characterization of a L-lysine-producing strain by continuous culture. Biotechnol. Bioeng., 39, 565-574 (1990).