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Volumn 8, Issue 6, 2013, Pages 898-903

Discovery and Characterization of ACT-335827, an Orally Available, Brain Penetrant Orexin Receptor Type1 Selective Antagonist

(7) Steiner, Michel A a Gatfield, John a Brisbare Roch, Catherine a Dietrich, Hendrik a Treiber, Alexander a Jenck, Francois a Boss, Christoph a

a ACTELION PHARMACEUTICALS LTD (Switzerland)

Author keywords

Anxiety; Neurotransmitters; Orexin receptor antagonists; Peptides; Sleep

Indexed keywords

ACT 335827; ALDEHYDE; ALMOREXANT; CALCIUM; ISOCYANATE; OREXIN A; PEPTIDE HORMONE RECEPTOR BLOCKING AGENT; TETRAHYDROPAPAVERINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DIASTEREOISOMER; DRINKING BEHAVIOR; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG EXPOSURE; FLUORESCENCE IMAGING; FOOTSHOCK; HIGH THROUGHPUT SCREENING; IC 50; MALE; MICROPLATE READER; NONHUMAN; PRIORITY JOURNAL; RAT; REM SLEEP; SOCIAL INTERACTION; STARTLE REFLEX; STRUCTURE ACTIVITY RELATION; WAKEFULNESS;

ADMINISTRATION, ORAL; ANIMALS; BENZENEACETAMIDES; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HUMANS; ISOQUINOLINES; OREXIN RECEPTORS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84878349332 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201300003 Document Type: Article

Times cited : (78)

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