Effects of light scattering on optical-resolution photoacoustic microscopy

Journal of Biomedical Optics

Volumn 17, Issue 12, 2012, Pages

  Liu, Yan ^a   Zhang, Chi ^a   Wang, Lihong V ^a  

^a WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

Author keywords

Focused ultrasonic transducer; Imaging depth; Light scattering; Monte Carlo simulation; Optical focusing; Photoacoustic microscopy; Spatial impulse response

Indexed keywords

FOCUSING; IMPULSE RESPONSE; LIGHT SCATTERING; MONTE CARLO METHODS; PHOTOACOUSTIC MICROSCOPY; SCATTERING; SIGNAL PROCESSING; ULTRASONIC TRANSDUCERS;

IMAGING DEPTH; OPTICAL FOCUSING; OPTICAL ILLUMINATION; OPTICAL IMAGING TECHNOLOGY; POINT-SPREAD FUNCTIONS; SPATIAL IMPULSE RESPONSE; TARGET AND BACKGROUND; TRANSPORT MEAN FREE PATH;

OPTICAL TRANSFER FUNCTION;

ALGORITHM; ARTICLE; ARTIFACT; AUTOMATED PATTERN RECOGNITION; COMPUTER ASSISTED DIAGNOSIS; COMPUTER SIMULATION; IMAGE ENHANCEMENT; LIGHT; METHODOLOGY; MICROSCOPY; PHOTOACOUSTICS; RADIATION SCATTERING; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL;

ALGORITHMS; ARTIFACTS; COMPUTER SIMULATION; IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; LIGHT; MICROSCOPY; MODELS, STATISTICAL; PATTERN RECOGNITION, AUTOMATED; PHOTOACOUSTIC TECHNIQUES; REPRODUCIBILITY OF RESULTS; SCATTERING, RADIATION; SENSITIVITY AND SPECIFICITY;

EID: 84878345142     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.JBO.17.12.126014     Document Type: Article

References (45)

1. J. M. Schmitt, A. Knuttel, and M. Yadlowsky, "Confocal microscopy in turbid media," J. Opt. Soc. Am. A. 11(8), 2226-2235 (1994).
2. J. P. Ying, F. Liu, and R. R. Alfano, "Spatial distribution of two-photon-excited fluorescence in scattering media," Appl. Opt. 38(10), 2151 (1999).
3. N. J. Durr et al., "Maximum imaging depth of two-photon autofluorescence microscopy in epithelial tissues," J. Biomed. Opt. 16(2), 026008 (2011).
4. P. Theer and W. Denk, "On the fundamental imaging-depth limit in twophoton microscopy," J. Opt. Soc. Am. A 23(12), 3139-3149 (2006).
5. P. Theer, "On the fundamental imaging-depth limit in two-photon microscopy," PhD Thesis, University of Heidelberg, (2004).
6. 3 regenerative amplifier,"Opt. Lett. 28(12), 1022-1024 (2003).
7. D. J. Smithies et al., "Signal attenuation and localization in optical coherence tomography studied by Monte Carlo simulation," Phys. Med. Biol. 43(10), 3025-3044 (1998).
8. R. Wang, "Signal degradation by coherence tomography multiple scattering in optical of dense tissue: a Monte Carlo study towards optical clearing of biotissues," Phys. Med. Biol. 47(13), 2281-2299 (2002).
9. G. Yao and L. V. Wang, "Monte Carlo simulation of an optical coherence tomography signal in homogeneous turbid media," Phys. Med. Biol. 44(9), 2307-2320 (1999).
10. V. Ntziachristos, "Going deeper than microscopy: the optical imaging frontier in biology," Nat. Methods 7(8), 603-614 (2010).
11. L. V. Wang and H. Wu, Biomedical Optics : Principles and Imaging, Wiley-Interscience, Hoboken, NJ (2007).
12. K. Maslov et al., "Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries," Opt. Lett. 33(9), 929-931 (2008).
13. X. S. Gan and M. Gu, "Effective point-spread function for fast image modeling and processing in microscopic imaging through turbid media," Opt. Lett. 24(11), 741-743 (1999).
14. L. V. Wang and G. Liang, "Absorption distribution of an optical beam focused into a turbid medium," Appl. Opt. 38(22), 4951-4958 (1999).
15. Y. Liu et al., "Effect of light scattering on optical-resolution photoacoustic microscopy," Proc. SPIE 8223, 82233S (2012).
16. A. Tycho et al., "Derivation of a Monte Carlo method for modeling heterodyne detection in optical coherence tomography systems," Appl. Opt. 41(31), 6676-6691 (2002).
17. F. Zhang et al., "Monte Carlo method for simulating optical coherence tomography signal in homogeneous turbid media," Proc. SPIE 7022, 702213 (2007).
18. L. V. Wang, S. L. Jacques, and L. Q. Zheng, "MCML - Monte-Carlo modeling of light transport in multilayered tissues," Comput. Meth. Prog. Bio. 47(2), 131-146 (1995).
19. B. E. A. Saleh and M. C. Teich, Fundamentals of Photonics, Wiley-Interscience, Hoboken, NJ (2007).
20. C. Zhang et al., "In vivo photoacoustic microscopy with 7.6-μm axial resolution using a commercial 125-MHz ultrasonic transducer,"J. Biomed. Opt. 17(11), 116016 (2012).
21. H. F. Zhang et al., "Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging," Nat. Biotechnol. 24(7), 848-851 (2006).
22. K. Wang et al., "Investigation of iterative image reconstruction in three-dimensional optoacoustic tomography," Phys. Med. Biol. 57(17), 5399-5423 (2012).
23. P. R. Stepanishen, "Transient radiation from pistons in an infinite planar baffle," J. Acoust. Soc. Am. 49(5), 1629 (1971).
24. M. Arditi, F. S. Foster, and J. W. Hunt, "Transient fields of concave annular arrays," Ultrason. Imag. 3(1), 37-61 (1981).
25. H. T. O'Neil, "Theory of focusing radiators," J. Acoust. Soc. Am. 21(5), 516-526 (1949).
26. F. Coulouvrat, "Continuous field radiated by a geometrically focused transducer - numerical investigation and comparison with an approximate model," J. Acoust. Soc. Am. 94(3), 1663-1675 (1993).
27. L. V. Wang and S. Hu, "Photoacoustic tomography: in vivo imaging from organelles to organs," Science 335(6075), 1458-1462 (2012).
28. K. Maslov, G. Stoica, and L. V. Wang, "In vivo dark-field reflection-mode photoacoustic microscopy," Opt. Lett. 30(6), 625-627 (2005).
29. D. K. Yao et al., "Optimal ultraviolet wavelength for in vivo photo-acoustic imaging of cell nuclei," J. Biomed. Opt. 17(5), 056004 (2012).
30. D. K. Yao et al., "In vivo label-free photoacoustic microscopy of cell nuclei by excitation of DNA and RNA," Opt. Lett. 35(24), 4139-4141 (2010).
31. E. Hecht, Optics, Addison-Wesley, Reading, MA (2002).
32. X. Xu, H. Liu, and L. V. Wang, "Time-reversed ultrasonically encoded optical focusing into scattering media," Nat. Photon. 5(3), 154-157 (2011).
33. C. K. Hayakawa et al., "Amplitude and phase of tightly focused laser beams in turbid media," Phys. Rev. Lett. 103(4), 043903 (2009).
34. P. Lai et al., "Reflection-mode time-reversed ultrasonically encoded optical focusing into turbid media," J. Biomed. Opt. 16(8), 080505 (2011).
35. Y. Suzuki et al., " Energy enhancement in time-reversed ultrasonically encoded optical focusing using a photorefractive polymer," J. Biomed. Opt. 17(8), 080507 (2012).
36. P. Lai et al., "Time-reversed ultrasonically encoded optical focusing in biological tissue," J. Biomed. Opt. 17(3), 030506 (2012).
37. K. Si, R. Fiolka, and M. Cui, "Fluorescence imaging beyond the ballistic regime by ultrasound-pulse-guided digital phase conjugation,"Nat. Photon. 6(10), 657-661 (2012).
38. Y. Wang et al., "Deep-tissue focal fluorescence imaging with digitally time-reversed ultrasound-encoded light," Nat. Commun. 3, 928 (2012).
39. Y. Yamaoka, M. Nambu, and T. Takamatsu, "Fine depth resolution of two-photon absorption-induced photoacoustic microscopy using low-frequency bandpass filtering," Opt Express 19(14), 13365-13377 (2011).
40. J. J. Yao et al., "Label-free oxygen-metabolic photoacoustic microscopy in vivo," J. Biomed. Opt. 16(7), 076003 (2011).
41. C. Zhang, K. Maslov, and L. V. Wang, "Subwavelength-resolution label-free photoacoustic microscopy of optical absorption in vivo,"Opt. Lett. 35(19), 3195-3197 (2010).
42. S. Ye et al., "Label-free imaging of zebrafish larvae in vivo by photo-acoustic microscopy," Biomed. Opt. Express 3(2), 360-365 (2012).
43. L. Thrane, H. T. Yura, and P. E. Andersen, "Analysis of optical coherence tomography systems based on the extended Huygens-Fresnel principle,"J. Opt. Soc. Am. A 17(3), 484-490 (2000).
44. L. Thrane et al., "Extraction of optical scattering parameters and attenuation compensation in optical coherence tomography images of multilayered tissue structures," Opt. Lett. 29(14), 1641-1643 (2004).
45. E. Alerstam et al., "Next-generation acceleration and code optimization for light transport in turbid media using GPUs," Biomed. Opt. Express 1(2), 658-675 (2010).