In vivo photoacoustic microscopy with 7.6-μm axial resolution using a commercial 125-MHz ultrasonic transducer

Journal of Biomedical Optics

Volumn 17, Issue 11, 2012, Pages

  Zhang, Chi ^a   Maslov, Konstantin ^a   Yao, Junjie ^a   Wang, Lihong V ^a  

^a WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

Author keywords

axial resolution; deconvolution; high frequency ultrasonic transducer; photoacoustic microscopy

Indexed keywords

AXIAL RESOLUTIONS; BIOLOGICAL TISSUES; EX-VIVO; HIGH FREQUENCY HF; IN-VIVO; LATERAL RESOLUTION; MELANOMA CELLS; SIGNAL-TO-NOISE RATIO DECREASE; SUBMICRON; ULTRASOUND DETECTION; WORKING DISTANCES;

DECONVOLUTION; PHOTOACOUSTIC MICROSCOPY; SIGNAL PROCESSING; ULTRASONIC APPLICATIONS; ULTRASONIC TRANSDUCERS;

TRANSDUCERS;

ACOUSTIC MICROSCOPY; ANIMAL; ARTICLE; EAR; ECHOGRAPHY; EQUIPMENT DESIGN; EXPERIMENTAL MELANOMA; HISTOLOGY; INSTRUMENTATION; LIGHT RELATED PHENOMENA; METHODOLOGY; MOUSE; PATHOLOGY; SIGNAL NOISE RATIO; SIGNAL PROCESSING; STATISTICS; TRANSDUCER; ULTRASOUND; VALIDATION STUDY;

ANIMALS; EAR; EQUIPMENT DESIGN; MELANOMA, EXPERIMENTAL; MICE; MICROSCOPY, ACOUSTIC; OPTICAL PHENOMENA; SIGNAL PROCESSING, COMPUTER-ASSISTED; SIGNAL-TO-NOISE RATIO; TRANSDUCERS; ULTRASONICS;

EID: 84870575915     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.JBO.17.11.116016     Document Type: Article

References (31)

1. Wang L. V., Hu S., " Photoacoustic tomography: in vivo imaging from organelles to organs.," Science 335 (6075), 1458 - 1462 (2012). SCIEAS 0036-8075 http://dx.doi.org/10.1126/science.1216210
2. Zhang H. F., et al., " Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging.," Nat. Biotech. 24 (7), 848 - 851 (2006). NABIF9 1087-0156 http://dx.doi.org/10.1038/nbt1220 (Pubitemid 44086627)
3. Yao D.-K., et al., " In vivo label-free photoacoustic microscopy of cell nuclei by excitation of DNA and RNA.," Opt. Lett. 35 (24), 4139 - 4141 (2010). OPLEDP 0146-9592 http://dx.doi.org/10.1364/OL.35.004139
4. Zhang C., et al., " Label-free photoacoustic microscopy of cytochrome c in cells.," Proc. SPIE 8223, 82231W (2012). PSISDG 0277-786X http://dx.doi.org/10.1117/12.906202
5. Zhang C., et al., " Label-free photoacoustic microscopy of myocardial sheet architecture.," J. Biomed. Opt. 17 (6), 060506 (2012). JBOPFO 1083-3668 http://dx.doi.org/10.1117/1.JBO.17.6.060506
6. Zhou Y., et al., " Photoacoustic microscopy of bilirubin.," J. Biomed. Opt. (submitted). JBOPFO 1083-3668
7. Xu Z., Zhu Q., Wang L. V., " In vivo photoacoustic tomography of mouse cerebral edema induced by cold injury.," J. Biomed. Opt. 16 (6), 066020 (2011). JBOPFO 1083-3668 http://dx.doi.org/10.1117/1.3584847
8. Wang H.-W., et al., " Label-free bond-selective imaging by listening to vibrationally excited molecules.," Phy. Rev. Lett. 106 (23), 238106 (2011). PRLTAO 0031-9007 http://dx.doi.org/10.1103/PhysRevLett.106.238106
9. Allen T. J., et al., " Spectroscopic photoacoustic imaging of lipid-rich plaques in the human aorta in the 740 to 1400nm wavelength range.," J. Biomed. Opt. 17 (6), 061209 (2012). JBOPFO 1083-3668 http://dx.doi.org/10.1117/1.JBO.17.6.061209
10. Yao J., et al., " Label-free oxygen-metabolic photoacoustic microscopy in vivo.," J. Biomed. Opt. 16 (7), 076003 (2011). JBOPFO 1083-3668 http://dx.doi.org/10.1117/1.3594786
11. Wang Y., Maslov K., Wang L. V., " Spectrally encoded photoacoustic microscopy using a digital mirror device.," J. Biomed. Opt. 17 (6), 066020 (2012). JBOPFO 1083-3668 http://dx.doi.org/10.1117/1.JBO.17.6.066020
12. Shah J., et al., " Photoacoustic imaging and temperature measurement for photothermal cancer therapy.," J. Biomed. Opt. 13 (3), 034024 (2008). JBOPFO 1083-3668 http://dx.doi.org/10.1117/1.2940362
13. Zhang C., Maslov K., Wang L. V., " Subwavelength-resolution label-free photoacoustic microscopy of optical absorption in vivo.," Opt. Lett. 35 (19), 3195 - 3197 (2010). OPLEDP 0146-9592 http://dx.doi.org/10.1364/ OL.35.003195
14. Zhang C., et al., " Reflection-mode submicron-resolution in vivo photoacoustic microscopy.," J. Biomed. Opt. 17 (2), 020501 (2012). JBOPFO 1083-3668 http://dx.doi.org/10.1117/1.JBO.17.2.020501
15. Wang L., et al., " Fast voice-coil scanning optical-resolution photoacoustic microscopy.," Opt. Lett. 36 (2), 139 - 141 (2011). OPLEDP 0146-9592 http://dx.doi.org/10.1364/OL.36.000139
16. Wang Y., et al., " Integrated photoacoustic and fluorescence confocal microscopy.," IEEE Trans. Biomed. Eng. 57 (10), 2576 - 2578 (2010). IEBEAX 0018-9294 http://dx.doi.org/10.1109/TBME.2010.2059026
17. Xie Z., et al., " Pure optical photoacoustic microscopy.," Opt. Express 19 (10), 9027 - 9034 (2011). OPEXFF 1094-4087 http://dx.doi.org/10. 1364/OE.19.009027
18. Zhang E. Z., et al., " Multimodal photoacoustic and optical coherence tomography scanner using an all optical detection scheme for 3-D morphological skin imaging.," Biomed. Opt. Express 2 (8), 2202 - 2215 (2011). BOEICL 2156-7085 http://dx.doi.org/10.1364/BOE.2.002202
19. Hu S., Maslov K., Wang L. V., " Second-generation optical-resolution photoacoustic microscopy with improved sensitivity and speed.," Opt. Lett. 36 (7), 1134 - 1136 (2011). OPLEDP 0146-9592 http://dx.doi.org/10.1364/OL.36. 001134
20. Jensen J. A., et al., " Deconvolution of in-vivo ultrasound B -mode images.," Ultrason. Imag. 15 (2), 122 - 133 (1993). ULIMD4 0161-7346 http://dx.doi.org/10.1006/uimg.1993.1010 (Pubitemid 23183275)
21. Ku G., et al., " Photoacoustic microscopy with 2-μm transverse resolution.," J. Biomed. Opt. 15 (2), 021302 (2010). JBOPFO 1083-3668 http://dx.doi.org/10.1117/1.3339912
22. Wang L. V., Wu H.-I., Biomedical Optics: Principles and Imaging, Wiley, Hoboken, New Jersey, pp. 164 - 169 (2007).
23. Yao J., et al., " Double-illumination photoacoustic microscopy.," Opt. Lett. 37 (4), 659 - 662 (2012). OPLEDP 0146-9592 http://dx.doi.org/10.1364/OL.37.000659
24. Wells P. T., Biomedical Ultrasonics, pp. 120 - 123, Academic Press, New York (1977).
25. Danielli A., et al., " Picosecond absorption relaxation measured with nanosecond laser photoacoustics.," Appl. Phys. Lett. 97 (16), 163701 (2010). APPLAB 0003-6951 http://dx.doi.org/10.1063/1.3500820
26. Liu Y., Zhang C., Wang L. V., " Effects of light scattering on optical-resolution photoacoustic microscopy.," J. Biomed. Opt. (submitted). JBOPFO 1083-3668
27. Phoong S.-M., Vaidyanathan P. P., " Time-varying filters and filter banks: some basic principles.," IEEE Trans. Signal Process. 44 (12), 2971 - 2987 (1996). ITPRED 1053-587X http://dx.doi.org/10.1109/78.553472 (Pubitemid 126778044)
28. Wang G., " The most general time-varying filter bank and time-varying lapped transforms.," IEEE Trans. Signal Process. 54 (10), 3775 - 3789 (2006). ITPRED 1053-587X http://dx.doi.org/10.1109/TSP.2006.879311 (Pubitemid 44500833)
29. Yamaoka Y., Nambu M., Takamatsu T., " Fine depth resolution of two-photon absorption-induced photoacoustic microscopy using low-frequency bandpass filtering.," Opt. Express 19 (14), 13365 - 13377 (2011). OPEXFF 1094-4087 http://dx.doi.org/10.1364/OE.19.013365
30. Helmchen F., Denk W., " Deep tissue two-photon microscopy.," Nat. Methods 2 (12), 932 - 940 (2005). 1548-7091 http://dx.doi.org/10.1038/ nmeth818 (Pubitemid 43108729)
31. Insana M. F., Cook L. T., " Bioelasticity imaging: system design.," Proc. SPIE 3659, 224 - 235 (1999). PSISDG 0277-786X http://dx.doi.org/10.1117/12.349497