The effects of polydeoxyribonucleotide on the survival of random pattern skin flaps in rats

Archives of Plastic Surgery

Volumn 40, Issue 3, 2013, Pages 181-186

  Chung, Kun Il ^a   Kim, Han Koo ^a   Kim, Woo Seob ^a   Bae, Tae Hui ^a  

^a Chung Ang University College of Medicine   (South Korea)

Author keywords

Angiogenesis modulating agents; Antigens; CD31; Polydeoxyribonucleotides; Surgical flaps; Vascular endothelial growth factors

Indexed keywords

CD31 ANTIGEN; POLYDEOXYRIBONUCLEOTIDE; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEEDING; CONTROLLED STUDY; GRAFT NECROSIS; GRANULATION TISSUE; HISTOLOGY; IMMUNOHISTOCHEMISTRY; MALE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PEDICLED SKIN FLAP; PROTEIN EXPRESSION; RAT; SKIN FLAP SURVIVAL; SURVIVAL; WOUND HEALING;

EID: 84878344885     PISSN: 22346163     EISSN: 22346171     Source Type: Journal    
DOI: 10.5999/aps.2013.40.3.181     Document Type: Article

References (24)

1. Folkman J, Shing Y. Angiogenesis. J Biol Chem 1992;267: 10931-10934.
2. Akhavani MA, Sivakumar B, Paleolog EM, et al. Angiogenesis and plastic surgery. J Plast Reconstr Aesthet Surg 2008; 61:1425-1437.
3. Padubidri A, Browne E Jr. Effect of vascular endothelial growth factor (VEGF) on survival of random extension of axial pattern skin flaps in the rat. Ann Plast Surg 1996;37: 604-611.
4. Kryger Z, Zhang F, Dogan T, et al. The effects of VEGF on survival of a random flap in the rat: examination of various routes of administration. Br J Plast Surg 2000;53:234-239.
5. Pierce GF, Tarpley JE, Yanagihara D, et al. Platelet-derived growth factor (BB homodimer), transforming growth factor-beta 1, and basic fibroblast growth factor in dermal wound healing. Neovessel and matrix formation and cessation of repair. Am J Pathol 1992;140:1375-1388.
6. Shukla A, Dubey MP, Srivastava R, et al. Differential expression of proteins during healing of cutaneous wounds in experimental normal and chronic models. Biochem Biophys Res Commun 1998;244:434-439.
7. Tonello G, Daglio M, Zaccarelli N, et al. Characterization and quantitation of the active polynucleotide fraction (PDRN) from human placenta, a tissue repair stimulating agent. J Pharm Biomed Anal 1996;14:1555-1560.
8. Bianchini P, Tellini N, Morani AM, et al. Pharmacological data on polydeoxyribonucleotide of human placenta. Int J Tissue React 1981;3:151-154.
9. Galeano M, Bitto A, Altavilla D, et al. Polydeoxyribonucleotide stimulates angiogenesis and wound healing in the genetically diabetic mouse. Wound Repair Regen 2008;16: 208-217.
10. Montesinos MC, Desai A, Chen JF, et al. Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A(2A) receptors. Am J Pathol 2002;160:2009-2018.
11. Montesinos MC, Gadangi P, Longaker M, et al. Wound healing is accelerated by agonists of adenosine A2 (G alpha s-linked) receptors. J Exp Med 1997;186:1615-1620.
12. McFarlane RM, Deyoung G, Henry RA. The Design of a Pedicle Flap in the Rat to Study Necrosis and Its Prevention. Plast Reconstr Surg 1965;35:177-182.
13. Bitto A, Polito F, Altavilla D, et al. Polydeoxyribonucleotide (PDRN) restores blood flow in an experimental model of peripheral artery occlusive disease. J Vasc Surg 2008;48: 1292-1300.
14. Gurunluoglu R, Meirer R, Shafighi M, et al. Gene therapy with adenovirus-mediated VEGF enhances skin flap prefabrication. Microsurgery 2005;25:433-441.
15. Thellung S, Florio T, Maragliano A, et al. Polydeoxyribonucleotides enhance the proliferation of human skin fibroblasts: involvement of A2 purinergic receptor subtypes. Life Sci 1999;64:1661-1674.
16. Altavilla D, Squadrito F, Polito F, et al. Activation of adenosine A2A receptors restores the altered cell-cycle machinery during impaired wound healing in genetically diabetic mice. Surgery 2011;149:253-261.
17. Guizzardi S, Galli C, Govoni P, et al. Polydeoxyribonucleotide (PDRN) promotes human osteoblast proliferation: a new proposal for bone tissue repair. Life Sci 2003;73:1973- 1983.
18. Bitto A, Galeano M, Squadrito F, et al. Polydeoxyribonucleotide improves angiogenesis and wound healing in experimental thermal injury. Crit Care Med 2008;36:1594-1602.
19. Sini P, Denti A, Cattarini G, et al. Effect of polydeoxyribonucleotides on human fibroblasts in primary culture. Cell Biochem Funct 1999;17:107-114.
20. Polito F, Bitto A, Galeano M, et al. Polydeoxyribonucleotide restores blood flow in an experimental model of ischemic skin flaps. J Vasc Surg 2012;55:479-488.
21. Lazzarotto M, Tomasello EM, Caporossi A. Clinical evaluation of corneal epithelialization after photorefractive keratectomy in patients treated with polydeoxyribonucleotide (PDRN) eye drops: a randomized, double-blind, placebo-controlled trial. Eur J Ophthalmol 2004;14:284-289.
22. Rubegni P, De Aloe G, Mazzatenta C, et al. Clinical evaluation of the trophic effect of polydeoxyribonucleotide (PDRN) in patients undergoing skin explants. A Pilot Study. Curr Med Res Opin 2001;17:128-131.
23. De Aloe G, Rubegni P, Biagioli M, et al. Skin graft donor site and use of polydeoxyribonucleotide as a treatment for skin regeneration: a randomized, controlled, double-blind, clinical trial. Wounds 2004;16:258-263.
24. Altavilla D, Bitto A, Polito F, et al. Polydeoxyribonucleotide (PDRN): a safe approach to induce therapeutic angiogenesis in peripheral artery occlusive disease and in diabetic foot ulcers. Cardiovasc Hematol Agents Med Chem 2009;7:313-321.