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Volumn 6, Issue 1, 2013, Pages 197-202

α-linolenic acid inhibits human renal cell carcinoma cell proliferation through PPAR-γ activation and COX-2 inhibition

Author keywords

linolenic acid; Cell proliferation; Cyclooxygenase 2; Peroxisome proliferator activated receptor ; Renal cell carcinoma

Indexed keywords

CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; LINOLENIC ACID; OMEGA 3 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; ROSIGLITAZONE;

EID: 84878337941     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2013.1336     Document Type: Article
Times cited : (40)

References (46)
  • 3
    • 0032860560 scopus 로고    scopus 로고
    • Omega-3 fatty acids as cancer chemopreventive agents
    • Rose DP and Connolly JM: Omega-3 fatty acids as cancer chemopreventive agents. Pharmacol Ther 83: 217-244, 1999.
    • (1999) Pharmacol Ther , vol.83 , pp. 217-244
    • Rose, D.P.1    Connolly, J.M.2
  • 4
    • 22144466941 scopus 로고    scopus 로고
    • Major dietary patterns and risk of renal cell carcinoma in a prospective cohort of Swedish women
    • Rashidkhani B, Akesson A, Lindblad P and Wolk A: Major dietary patterns and risk of renal cell carcinoma in a prospective cohort of Swedish women. J Nutr 135: 1757-1762, 2005.
    • (2005) J Nutr , vol.135 , pp. 1757-1762
    • Rashidkhani, B.1    Akesson, A.2    Lindblad, P.3    Wolk, A.4
  • 5
    • 33748904093 scopus 로고    scopus 로고
    • Long-term fatty fish consumption and renal cell carcinoma incidence in women
    • Wolk A, Larsson SC, Johansson JE and Ekman P: Long-term fatty fish consumption and renal cell carcinoma incidence in women. JAMA 296: 1371-1376, 2006.
    • (2006) JAMA , vol.296 , pp. 1371-1376
    • Wolk, A.1    Larsson, S.C.2    Johansson, J.E.3    Ekman, P.4
  • 7
    • 67649804559 scopus 로고    scopus 로고
    • Anticancer actions of omega-3 fatty acids -current state and future perspectives
    • Wendel M and Heller AR: Anticancer actions of omega-3 fatty acids -current state and future perspectives. Anticancer Agents Med Chem 9: 457-470, 2009.
    • (2009) Anticancer Agents Med Chem , vol.9 , pp. 457-470
    • Wendel, M.1    Heller, A.R.2
  • 8
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Nuclear control of metabolism
    • Desvergne B and Wahli W: Peroxisome proliferator-activated receptors: Nuclear control of metabolism. Endocr Rev 20: 649-688, 1999.
    • (1999) Endocr Rev , vol.20 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 9
    • 32644460092 scopus 로고    scopus 로고
    • From molecular action to physiological outputs: Peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions
    • Feige JN, Gelman L, Michalik L, Desvergne B and Wahli W: From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions. Prog Lipid Res 45: 120-159, 2006.
    • (2006) Prog Lipid Res , vol.45 , pp. 120-159
    • Feige, J.N.1    Gelman, L.2    Michalik, L.3    Desvergne, B.4    Wahli, W.5
  • 10
    • 35448982383 scopus 로고    scopus 로고
    • Biology of PPAR gamma in cancer: A critical review on existing lacunae
    • Krishnan A, Nair SA and Pillai MR: Biology of PPAR gamma in cancer: a critical review on existing lacunae. Curr Mol Med 7: 532-540, 2007.
    • (2007) Curr Mol Med , vol.7 , pp. 532-540
    • Krishnan, A.1    Nair, S.A.2    Pillai, M.R.3
  • 13
    • 70949100689 scopus 로고    scopus 로고
    • Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking beta-catenin and cyclooxygenase-2
    • Lim K, Han C, Dai Y, Shen M and Wu T: Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking beta-catenin and cyclooxygenase-2. Mol Cancer Ther 8: 3046-3055, 2009.
    • (2009) Mol Cancer Ther , vol.8 , pp. 3046-3055
    • Lim, K.1    Han, C.2    Dai, Y.3    Shen, M.4    Wu, T.5
  • 15
    • 0035220046 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-2 in canine renal cell carcinoma
    • Khan KN, Stanfield KM, Trajkovic D and Knapp DW: Expression of cyclooxygenase-2 in canine renal cell carcinoma. Vet Pathol 38: 116-119, 2001.
    • (2001) Vet Pathol , vol.38 , pp. 116-119
    • Khan, K.N.1    Stanfield, K.M.2    Trajkovic, D.3    Knapp, D.W.4
  • 17
    • 0033605677 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo
    • Xin X, Yang S, Kowalski J and Gerritsen ME: Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo. J Biol Chem 274: 9116-9121, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 9116-9121
    • Xin, X.1    Yang, S.2    Kowalski, J.3    Gerritsen, M.E.4
  • 18
    • 0025201334 scopus 로고
    • Effects of fatty acids and inhibitors of eicosanoid synthesis on the growth of a human breast cancer cell line in culture
    • Rose DP and Connolly JM: Effects of fatty acids and inhibitors of eicosanoid synthesis on the growth of a human breast cancer cell line in culture. Cancer Res 50: 7139-7144, 1990.
    • (1990) Cancer Res , vol.50 , pp. 7139-7144
    • Rose, D.P.1    Connolly, J.M.2
  • 19
    • 0028906908 scopus 로고
    • Influence of diets containing eicosapentaenoic or docosahexaenoic acid on growth and metastasis of breast cancer cells in nude mice
    • Rose DP, Connolly JM, Rayburn J and Coleman M: Influence of diets containing eicosapentaenoic or docosahexaenoic acid on growth and metastasis of breast cancer cells in nude mice. J Natl Cancer Inst 87: 587-592, 1995.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 587-592
    • Rose, D.P.1    Connolly, J.M.2    Rayburn, J.3    Coleman, M.4
  • 21
    • 0025461599 scopus 로고
    • Dietary fat and cancer: Consistency of the epidemiologic data, and disease prevention that may follow from a practical reduction in fat consumption
    • Prentice RL and Sheppard L: Dietary fat and cancer: consistency of the epidemiologic data, and disease prevention that may follow from a practical reduction in fat consumption. Cancer Causes Control 1: 81-109, 1990.
    • (1990) Cancer Causes Control , vol.1 , pp. 81-109
    • Prentice, R.L.1    Sheppard, L.2
  • 23
    • 0042889393 scopus 로고    scopus 로고
    • Diet and lung cancer risk from a 14-year population-based prospective study in Japan: With special reference to fish consumption
    • Takezaki T, Inoue M, Kataoka H, Ikeda S, Yoshida M, Ohashi Y, Tajima K and Tominaga S: Diet and lung cancer risk from a 14-year population-based prospective study in Japan: with special reference to fish consumption. Nutr Cancer 45: 160-167, 2003.
    • (2003) Nutr Cancer , vol.45 , pp. 160-167
    • Takezaki, T.1    Inoue, M.2    Kataoka, H.3    Ikeda, S.4    Yoshida, M.5    Ohashi, Y.6    Tajima, K.7    Tominaga, S.8
  • 24
    • 13944274395 scopus 로고    scopus 로고
    • PPAR gamma as a metabolic regulator: Insights from genomics and pharmacology
    • Savage DB: PPAR gamma as a metabolic regulator: insights from genomics and pharmacology. Expert Rev Mol Med 7: 1-16, 2005.
    • (2005) Expert Rev Mol Med , vol.7 , pp. 1-16
    • Savage, D.B.1
  • 25
    • 10644251916 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma calls for activation in moderation: Lessons from genetics and pharmacology
    • Knouff C and Auwerx J: Peroxisome proliferator-activated receptor-gamma calls for activation in moderation: lessons from genetics and pharmacology. Endocr Rev 25: 899-918, 2004.
    • (2004) Endocr Rev , vol.25 , pp. 899-918
    • Knouff, C.1    Auwerx, J.2
  • 26
    • 0036399805 scopus 로고    scopus 로고
    • PPAR(gamma) and glucose homeostasis
    • Picard F and Auwerx J: PPAR(gamma) and glucose homeostasis. Annu Rev Nutr 22: 167-197, 2002.
    • (2002) Annu Rev Nutr , vol.22 , pp. 167-197
    • Picard, F.1    Auwerx, J.2
  • 28
    • 53149131328 scopus 로고    scopus 로고
    • Omega-3 fatty acids and PPARgamma in cancer
    • Edwards IJ and O'Flaherty JT: Omega-3 fatty acids and PPARgamma in cancer. PPAR Res 2008: 358052, 2008.
    • (2008) PPAR Res , vol.2008 , pp. 358052
    • Edwards, I.J.1    O'Flaherty, J.T.2
  • 29
    • 42449125303 scopus 로고    scopus 로고
    • Are fish oil omega-3 long-chain fatty acids and their derivatives peroxisome proliferator-activated receptor agonists?
    • Gani OA: Are fish oil omega-3 long-chain fatty acids and their derivatives peroxisome proliferator-activated receptor agonists? Cardiovasc Diabetol 7: 6, 2008.
    • (2008) Cardiovasc Diabetol , vol.7 , pp. 6
    • Gani, O.A.1
  • 30
    • 66149157824 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma in bladder cancer: A promising therapeutic target
    • Mansure JJ, Nassim R and Kassouf W: Peroxisome proliferator-activated receptor gamma in bladder cancer: a promising therapeutic target. Cancer Biol Ther 8: 6-15, 2009.
    • (2009) Cancer Biol Ther , vol.8 , pp. 6-15
    • Mansure, J.J.1    Nassim, R.2    Kassouf, W.3
  • 31
    • 85047685824 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma and lung cancer biology: Implications for therapy
    • Roman J: Peroxisome proliferator-activated receptor gamma and lung cancer biology: implications for therapy. J Investig Med 56: 528-533, 2008.
    • (2008) J Investig Med , vol.56 , pp. 528-533
    • Roman, J.1
  • 32
    • 35248869149 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma (PPARgamma) and colorectal carcinogenesis
    • Voutsadakis IA: Peroxisome proliferator-activated receptor gamma (PPARgamma) and colorectal carcinogenesis. J Cancer Res Clin Oncol 133: 917-928, 2007.
    • (2007) J Cancer Res Clin Oncol , vol.133 , pp. 917-928
    • Voutsadakis, I.A.1
  • 33
    • 68949117981 scopus 로고    scopus 로고
    • Selective cyclooxygenase-2 (COX-2) inhibitors used for preventing or regressing cancer
    • de Souza Pereira R: Selective cyclooxygenase-2 (COX-2) inhibitors used for preventing or regressing cancer. Recent Pat Anticancer Drug Discov 4: 157-163, 2009.
    • (2009) Recent Pat Anticancer Drug Discov , vol.4 , pp. 157-163
    • de Souza Pereira, R.1
  • 34
    • 64049109107 scopus 로고    scopus 로고
    • Cyclooxygenase-2 (cox-2) blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung
    • Harris RE: Cyclooxygenase-2 (cox-2) blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung. Inflammopharmacology 17: 55-67, 2009.
    • (2009) Inflammopharmacology , vol.17 , pp. 55-67
    • Harris, R.E.1
  • 35
    • 60849093525 scopus 로고    scopus 로고
    • Cyclooxygenase-2 (COX-2) in carcinogenesis and selective COX-2 inhibitors for chemoprevention in gastrointestinal cancers
    • Fujimura T, Ohta T, Oyama K, Miyashita T and Miwa K: Cyclooxygenase-2 (COX-2) in carcinogenesis and selective COX-2 inhibitors for chemoprevention in gastrointestinal cancers. J Gastrointest Cancer 38: 78-82, 2007.
    • (2007) J Gastrointest Cancer , vol.38 , pp. 78-82
    • Fujimura, T.1    Ohta, T.2    Oyama, K.3    Miyashita, T.4    Miwa, K.5
  • 36
    • 0033175648 scopus 로고    scopus 로고
    • The association between a mutated ras gene and cyclooxygenase-2 expression in human breast cancer cell lines
    • Gilhooly EM and Rose DP: The association between a mutated ras gene and cyclooxygenase-2 expression in human breast cancer cell lines. Int J Oncol 15: 267-270, 1999.
    • (1999) Int J Oncol , vol.15 , pp. 267-270
    • Gilhooly, E.M.1    Rose, D.P.2
  • 37
    • 0345505237 scopus 로고    scopus 로고
    • Cyclooxygenase-2 and prostate carcinogenesis
    • Hussain T, Gupta S and Mukhtar H: Cyclooxygenase-2 and prostate carcinogenesis. Cancer Lett 191: 125-135, 2003.
    • (2003) Cancer Lett , vol.191 , pp. 125-135
    • Hussain, T.1    Gupta, S.2    Mukhtar, H.3
  • 38
    • 67349233455 scopus 로고    scopus 로고
    • Cyclooxygenase-2/prostaglandin e2 pathway mediates icariside II induced apoptosis in human PC-3 prostate cancer cells
    • Lee KS, Lee HJ, Ahn KS, Kim SH, Nam D, Kim DK, Choi DY, Ahn KS, Lu J and Kim SH: Cyclooxygenase-2/prostaglandin e2 pathway mediates icariside II induced apoptosis in human PC-3 prostate cancer cells. Cancer Lett 280: 93-100, 2009.
    • (2009) Cancer Lett , vol.280 , pp. 93-100
    • Lee, K.S.1    Lee, H.J.2    Ahn, K.S.3    Kim, S.H.4    Nam, D.5    Kim, D.K.6    Choi, D.Y.7    Ahn, K.S.8    Lu, J.9    Kim, S.H.10
  • 39
    • 59349085139 scopus 로고    scopus 로고
    • Inhibition of COX-2 and activation of peroxisome proliferator-activated receptor gamma synergistically inhibits proliferation and induces apoptosis of human pancreatic carcinoma cells
    • Sun WH, Chen GS, Ou XL, Yang Y, Luo C, Zhang Y, Shao Y, Xu HC, Xiao B, Xue YP, Zhou SM, Zhao QS and Ding GX: Inhibition of COX-2 and activation of peroxisome proliferator-activated receptor gamma synergistically inhibits proliferation and induces apoptosis of human pancreatic carcinoma cells. Cancer Lett 275: 247-255, 2009.
    • (2009) Cancer Lett , vol.275 , pp. 247-255
    • Sun, W.H.1    Chen, G.S.2    Ou, X.L.3    Yang, Y.4    Luo, C.5    Zhang, Y.6    Shao, Y.7    Xu, H.C.8    Xiao, B.9    Xue, Y.P.10    Zhou, S.M.11    Zhao, Q.S.12    Ding, G.X.13
  • 40
    • 8644277977 scopus 로고    scopus 로고
    • Impact of cyclooxygenase-2 gene expression on tumor invasiveness in a human renal cell carcinoma cell line
    • Chen Q, Shinohara N, Abe T, Harabayashi T and Nonomura K: Impact of cyclooxygenase-2 gene expression on tumor invasiveness in a human renal cell carcinoma cell line. J Urol 172: 2153-2157, 2004.
    • (2004) J Urol , vol.172 , pp. 2153-2157
    • Chen, Q.1    Shinohara, N.2    Abe, T.3    Harabayashi, T.4    Nonomura, K.5
  • 41
    • 11144256492 scopus 로고    scopus 로고
    • Comparative analysis of COX-2, vascular endothelial growth factor and microvessel density in human renal cell carcinomas
    • Hemmerlein B, Galuschka L, Putzer N, Zischkau S and Heuser M: Comparative analysis of COX-2, vascular endothelial growth factor and microvessel density in human renal cell carcinomas. Histopathology 45: 603-611, 2004.
    • (2004) Histopathology , vol.45 , pp. 603-611
    • Hemmerlein, B.1    Galuschka, L.2    Putzer, N.3    Zischkau, S.4    Heuser, M.5
  • 42
    • 40849140987 scopus 로고    scopus 로고
    • Antitumorigenic effects of peroxisome proliferator-activated receptor-gamma in non-small-cell lung cancer cells are mediated by suppression of cyclooxygenase-2 via inhibition of nuclear factor-kappaB
    • Bren-Mattison Y, Meyer AM, Van Putten V, Li H, Kuhn K, Stearman R, Weiser-Evans M, Winn RA, Heasley LE and Nemenoff RA: Antitumorigenic effects of peroxisome proliferator-activated receptor-gamma in non-small-cell lung cancer cells are mediated by suppression of cyclooxygenase-2 via inhibition of nuclear factor-kappaB. Mol Pharmacol 73: 709-717, 2008.
    • (2008) Mol Pharmacol , vol.73 , pp. 709-717
    • Bren-Mattison, Y.1    Meyer, A.M.2    van Putten, V.3    Li, H.4    Kuhn, K.5    Stearman, R.6    Weiser-Evans, M.7    Winn, R.A.8    Heasley, L.E.9    Nemenoff, R.A.10
  • 43
    • 34247613578 scopus 로고    scopus 로고
    • Charveron M and Pipy B: N-3 and n-6 polyunsaturated fatty acids induce the expression of COX-2 via PPARgamma activation in human keratinocyte HaCaT cells
    • Chêne G, Dubourdeau M, Balard P, Escoubet-Lozach L, Orfila C, Berry A, Bernad J, Aries MF, Charveron M and Pipy B: n-3 and n-6 polyunsaturated fatty acids induce the expression of COX-2 via PPARgamma activation in human keratinocyte HaCaT cells. Biochim Biophys Acta 1771: 576-589, 2007.
    • (2007) Biochim Biophys Acta , vol.1771 , pp. 576-589
    • Chêne, G.1    Dubourdeau, M.2    Balard, P.3    Escoubet-Lozach, L.4    Orfila, C.5    Berry, A.6    Bernad, J.7    Aries, M.F.8
  • 45
    • 33746190686 scopus 로고    scopus 로고
    • Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells
    • Azevedo-Martins AK, Monteiro AP, Lima CL, Lenzen S and Curi R: Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. Toxicol In Vitro 20: 1106-1113, 2006.
    • (2006) Toxicol In Vitro , vol.20 , pp. 1106-1113
    • Azevedo-Martins, A.K.1    Monteiro, A.P.2    Lima, C.L.3    Lenzen, S.4    Curi, R.5
  • 46
    • 20444439032 scopus 로고    scopus 로고
    • Toxicity of a mixture of fatty acids on human blood lymphocytes and leukaemia cell lines
    • Otton R and Curi R: Toxicity of a mixture of fatty acids on human blood lymphocytes and leukaemia cell lines. Toxicol In Vitro 19: 749-755, 2005.
    • (2005) Toxicol In Vitro , vol.19 , pp. 749-755
    • Otton, R.1    Curi, R.2


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