Inactivation of ERK accelerates erythroid differentiation of K562 cells induced by herbimycin A and STI571 while activation of MEK1 interferes with it

Molecular and Cellular Biochemistry

Volumn 258, Issue 1-2, 2004, Pages 25-33

  Kawano, Takeshi ^a   Horiguchi Yamada, Junko ^a   Iwase, Satsuki ^a   Furukawa, Yusuke ^b   Kano, Yasuhiko ^c   Yamada, Hisashi ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JICHI MEDICAL UNIVERSITY   (Japan)

^c TOCHIGI CANCER CENTER   (Japan)

Author keywords

ERK; Erythroid differentiation; Herbimycin A; K562; MEK; STI571

Indexed keywords

BCR ABL PROTEIN; GLYCOPHORIN A; HERBIMYCIN A; IMATINIB; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1;

ARTICLE; CELL DIFFERENTIATION; CELL STRAIN K 562; CHIMERA; CONTROLLED STUDY; DNA MODIFICATION; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INACTIVATION; ERYTHROID CELL; HUMAN; HUMAN CELL; LEUKEMIA; PROTEIN EXPRESSION;

BENZOQUINONES; CELL DIFFERENTIATION; ENZYME ACTIVATION; ENZYME INHIBITORS; ERYTHROBLASTS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FUSION PROTEINS, BCR-ABL; GLYCOPHORIN; HUMANS; K562 CELLS; LACTAMS, MACROCYCLIC; MAP KINASE KINASE 1; PIPERAZINES; PROTEIN-TYROSINE-PHOSPHATASE; PYRIMIDINES; QUINONES; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 1442355343     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:MCBI.0000012830.96393.b9     Document Type: Article

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