The protective effects of grape seed extract on MDA, AOPP, apoptosis and eNOS expression in testicular torsion: An experimental study

World Journal of Urology

Volumn 31, Issue 3, 2013, Pages 615-622

  Bayatli, Firuze ^a   Akkuş, Derya ^a   Kilic, Eser ^a   Saraymen, Recep ^a   Sönmez, Mehmet Fatih ^a  

^a ERCIYES UNIVERSITY   (Turkey)

Author keywords

Apoptosis; eNOS; Grape seed proanthocyanidin extract; Rat; Testicular torsion

Indexed keywords

ADVANCED OXIDATION PROTEIN PRODUCT; ANTIOXIDANT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GRAPE SEED EXTRACT; MALONALDEHYDE;

ANIMAL; APOPTOSIS; ARTICLE; DISEASE MODEL; DRUG EFFECT; MALE; METABOLISM; PATHOLOGY; RAT; REPERFUSION INJURY; TESTIS; TESTIS TORSION; TREATMENT OUTCOME; WISTAR RAT;

ADVANCED OXIDATION PROTEIN PRODUCTS; ANIMALS; ANTIOXIDANTS; APOPTOSIS; DISEASE MODELS, ANIMAL; GRAPE SEED EXTRACT; MALE; MALONDIALDEHYDE; NITRIC OXIDE SYNTHASE TYPE III; RATS; RATS, WISTAR; REPERFUSION INJURY; SPERMATIC CORD TORSION; TESTIS; TREATMENT OUTCOME;

EID: 84878239090     PISSN: 07244983     EISSN: 14338726     Source Type: Journal    
DOI: 10.1007/s00345-013-1049-8     Document Type: Article

References (30)

1. Dokmeci D, Kanter M, Inan M, Aydogdu N, Basaran UN, Yalcin O, Turan FN (2007) Protective effects of ibuprofen on testicular torsion/detorsion-induced ischemia/reperfusion injury in rats. Arch Toxicol 81(9): 655-663.
2. Tamamura M, Saito M, Kinoshita Y, Shimizu S, Satoh I, Shomori K, Dimitriadis F, Satoh K (2010) Protective effect of edaravone, a free-radical scavenger, on ischaemia-reperfusion injury in the rat testis. BJU Int 105(6): 870-876.
3. Turkmen S, Mentese A, Karaguzel E, Karaca Y, Kucuk A, Uzun A, Yulug E, Turedi S (2012) A comparison of the effects of N-acetylcysteine and ethyl pyruvate on experimental testicular ischemia-reperfusion injury. Fertil Steril 98(3): 626-631.
4. Ariga T (2004) The antioxidative function, preventive action on disease and utilization of proanthocyanidins. BioFactors 21(1-4): 197-201.
5. Guler A, Sahin MA, Yucel O, Yokusoglu M, Gamsizkan M, Ozal E, Demirkilic U, Arslan M (2011) Proanthocyanidin prevents myocardial ischemic injury in adult rats. Med Sci Monit 17(11): BR326-BR331.
6. Ulusoy S, Ozkan G, Yucesan FB, Ersoz S, Orem A, Alkanat M, Yulug E, Kaynar K, Al S (2012) Anti-apoptotic and anti-oxidant effects of grape seed proanthocyanidin extract in preventing cyclosporine A-induced nephropathy. Nephrology (Carlton) 17(4): 372-379.
7. Su L, Deng Y, Zhang Y, Li C, Zhang R, Sun Y, Zhang K, Li J, Yao S (2011) Protective effects of grape seed procyanidin extract against nickel sulfate-induced apoptosis and oxidative stress in rat testes. Toxicol Mech Methods 21(6): 487-494.
8. Kanter M (2010) Protective effects of melatonin on testicular torsion/detorsion-induced ischemia-reperfusion injury in rats. Exp Mol Pathol 89(3): 314-320.
9. Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95(2): 351-358.
10. Witko-Sarsat V, Friedlander M, Capeillere-Blandin C, Nguyen-Khoa T, Nguyen AT, Zingraff J, Jungers P, Descamps-Latscha B (1996) Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney Int 49(5): 1304-1313.
11. Johnsen SG (1970) Testicular biopsy score count-a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Hormones 1(1): 2-25.
12. Turner TT, Brown KJ (1993) Spermatic cord torsion: loss of spermatogenesis despite return of blood flow. Biol Reprod 49(2): 401-407.
13. Uguralp S, Bay Karabulut A, Mizrak B, Kaymaz F, Kiziltay A, Hasirci N (2004) The effect of sustained and local administration of epidermal growth factor on improving bilateral testicular tissue after torsion. Urol Res 32(5): 323-331.
14. Dokmeci D, Inan M, Basaran UN, Yalcin O, Aydogdu N, Turan FN, Uz YH (2007) Protective effect of l-carnitine on testicular ischaemia-reperfusion injury in rats. Cell Biochem Funct 25(6): 611-618.
15. Aitken RJ, Roman SD (2008) Antioxidant systems and oxidative stress in the testes. Oxid Med Cell Longev 1(1): 15-24.
16. Turner TT, Tung KS, Tomomasa H, Wilson LW (1997) Acute testicular ischemia results in germ cell-specific apoptosis in the rat. Biol Reprod 57(6): 1267-1274.
17. Aksoy H, Yapanoglu T, Aksoy Y, Ozbey I, Turhan H, Gursan N (2007) Dehydroepiandrosterone treatment attenuates reperfusion injury after testicular torsion and detorsion in rats. J Pediatr Surg 42(10): 1740-1744.
18. Yildiz H, Durmus AS, Simsek H, Yaman M (2012) Dose-dependent protective effect of sildenafil citrate on testicular injury after torsion/detorsion in rats. Andrologia 44(Suppl 1): 300-306.
19. Taskara E, Gor A, Kutlu O, Karaguzel E, Cobanoglu U, Topbas M, Senel AC (2011) Does propofol prevent testicular ischemia-reperfusion injury due to torsion in the long term? Pediatr Surg Int 27(9): 1003-1007.
20. Sehirli O, Ozel Y, Dulundu E, Topaloglu U, Ercan F, Sener G (2008) Grape seed extract treatment reduces hepatic ischemia-reperfusion injury in rats. Phytother Res 22(1): 43-48.
21. Guven C, Borcek AO, Cemil B, Kurt G, Yildirim Z, Ucankus NL, Kilic N, Ceviker N (2010) Neuroprotective effects of infliximab in experimental spinal cord ischemic injury. J Clin Neurosci 17(12): 1563-1567.
22. Skvarilova M, Bulava A, Stejskal D, Adamovska S, Bartek J (2005) Increased level of advanced oxidation products (AOPP) as a marker of oxidative stress in patients with acute coronary syndrome. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 149(1): 83-87.
23. Billig H, Furuta I, Rivier C, Tapanainen J, Parvinen M, Hsueh AJ (1995) Apoptosis in testis germ cells: developmental changes in gonadotropin dependence and localization to selective tubule stages. Endocrinology 136(1): 5-12.
24. Shiraishi K, Naito K, Yoshida K (2001) Nitric oxide promotes germ cell necrosis in the delayed phase after experimental testicular torsion of rat. Biol Reprod 65(2): 514-521.
25. Aktoz T, Kanter M, Aktas C (2010) Protective effects of quercetin on testicular torsion/detorsion-induced ischaemia-reperfusion injury in rats. Andrologia 42(6): 376-383.
26. Moon C, Ahn M, Kim S, Yasuzumi F, Shin T (2005) Increased expression of both constitutive and inducible forms of nitric oxide synthase in the delayed phase of acute experimental testicular torsion. J Vet Med Sci 67(4): 453-456.
27. Kono T, Saito M, Kinoshita Y, Satoh I, Shinbori C, Satoh K (2006) Real-time monitoring of nitric oxide and blood flow during ischemia-reperfusion in the rat testis. Mol Cell Biochem 286(1-2): 139-145.
28. Shiraishi K, Yoshida K, Naito K (2003) Activation of endothelial nitric oxide synthase in contralateral testis during unilateral testicular torsion in rats. Arch Androl 49(3): 179-190.
29. Akgul T, Karaguzel E, Surer H, Yagmurdur H, Ayyildiz A, Ustun H, Germiyanoglu C (2009) Ginkgo biloba (EGB 761) affects apoptosis and nitric-oxide synthases in testicular torsion: an experimental study. Int Urol Nephrol 41(3): 531-536.
30. Kanter M (2011) Protective effects of Ginkgo biloba (EGb 761) on testicular torsion/detorsion-induced ischemia-reperfusion injury in rats. Exp Mol Pathol 91(3): 708-713.