Expression of matrix metalloproteinases and their inhibitors in the woodchuck model of hepatocellular carcinoma

Journal of Medical Virology

Volumn 85, Issue 7, 2013, Pages 1127-1138

  Ochoa Callejero, Laura ^a   Toshkov, Ilia ^b   Menne, Stephan ^c   Martínez, Alfredo ^a  

^a CENTER FOR BIOMEDICAL RESEARCH OF LA RIOJA CIBIR   (Spain)

^b CLEVELAND BIOLABS INC   (United States)

^c GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Extracellular matrix remodeling; Liver cancer; Marmota monax; Metalloproteinases; Pharmacological inhibitors

Indexed keywords

GELATINASE A; GELATINASE B; MATRILYSIN; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMALE; GENE SEQUENCE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIVER CELL CARCINOMA; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; UPREGULATION; WESTERN BLOTTING; WOODCHUCK; ZYMOGRAPHY;

EXTRACELLULAR MATRIX REMODELING; LIVER CANCER; MARMOTA MONAX; METALLOPROTEINASES; PHARMACOLOGICAL INHIBITORS;

ANIMALS; CARCINOMA, HEPATOCELLULAR; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HEPATITIS B VIRUS, WOODCHUCK; HOST-PATHOGEN INTERACTIONS; IMMUNOHISTOCHEMISTRY; LIVER; MALE; MARMOTA; MATRIX METALLOPROTEINASES; PROTEASE INHIBITORS; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84878219654     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.23571     Document Type: Article

References (35)

1. Altadill A, Rodriguez M, Gonzalez LO, Junquera S, Corte MD, Gonzalez-Dieguez ML, Linares A, Barbon E, Fresno-Forcelledo M, Rodrigo L, Vizoso FJ. 2009. Liver expression of matrix metalloproteases and their inhibitors in hepatocellular carcinoma. Dig Liver Dis 41:740-748.
2. Arii S, Mise M, Harada T, Furutani M, Ishigami S, Niwano M, Mizumoto M, Fukumoto M, Imamura M. 1996. Overexpression of matrix metalloproteinase 9 gene in hepatocellular carcinoma with invasive potential. Hepatology 24:316-322.
3. Chen R, Cui J, Xu C, Xue T, Guo K, Gao D, Liu Y, Ye S, Ren Z. 2012. The significance of MMP-9 over MMP-2 in HCC invasiveness and recurrence of hepatocellular carcinoma after curative resection. Ann Surg Oncol 19:S375-S384.
4. Chung TW, Moon SK, Lee YC, Kim JG, Ko JH, Kim CH. 2002. Enhanced expression of matrix metalloproteinase-9 by hepatitis B virus infection in liver cells. Arch Biochem Biophys 408:147-154.
5. Consolo M, Amoroso A, Spandidos DA, Mazzarino MC. 2009. Matrix metalloproteinases and their inhibitors as markers of inflammation and fibrosis in chronic liver disease (Review). Int J Mol Med 24:143-152.
6. Cote PJ, Korba BE, Miller RH, Jacob JR, Baldwin BH, Hornbuckle WE, Purcell RH, Tennant BC, Gerin JL. 2000. Effects of age and viral determinants on chronicity as an outcome of experimental woodchuck hepatitis virus infection. Hepatology 31:190-200.
7. Das A, Maini MK. 2010. Innate and adaptive immune responses in hepatitis B virus infection. Dig Dis 28:126-132.
8. El-Serag HB. 2011. Hepatocellular carcinoma. N Engl J Med 365:1118-1127.
9. Fioravanti J, Gomar C, Medina-Echeverz J, Otano I, Benito A, Prieto J, Gonzalez-Aseguinolaza G, Berraondo P. 2011. Characterization of woodchuck apolipoprotein A-I: A new tool for drug delivery and identification of altered isoforms in the woodchuck chronic hepatitis model. J Med Virol 83:1221-1229.
10. Fletcher SP, Chin DJ, Ji Y, Iniguez AL, Taillon B, Swinney DC, Ravindran P, Cheng DT, Bitter H, Lopatin U, Ma H, Klumpp K, Menne S. 2012. Transcriptomic analysis of the woodchuck model of chronic hepatitis B. Hepatology 56:820-830.
11. Gialeli C, Theocharis AD, Karamanos NK. 2011. Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting. FEBS J 278:16-27.
12. Giannelli G, Bergamini C, Marinosci F, Fransvea E, Quaranta M, Lupo L, Schiraldi O, Antonaci S. 2002. Clinical role of MMP-2/TIMP-2 imbalance in hepatocellular carcinoma. Int J Cancer 97:425-431.
13. Guo RP, Zhong C, Shi M, Zhang CQ, Wei W, Zhang YQ, Li JQ. 2006. Clinical value of apoptosis and angiogenesis factors in estimating the prognosis of hepatocellular carcinoma. J Cancer Res Clin Oncol 132:547-555.
14. Heussen C, Dowdle EB. 1980. Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates. Anal Biochem 102:196-202.
15. Hu X, Beeton C. 2010. Detection of functional matrix metalloproteinases by zymography. J Vis Exp 45:2445.
16. Huang CC, Chuang JH, Chou MH, Wu CL, Chen CM, Wang CC, Chen YS, Chen CL, Tai MH. 2005. Matrilysin (MMP-7) is a major matrix metalloproteinase upregulated in biliary atresia-associated liver fibrosis. Mod Pathol 18:941-950.
17. Jiang YF, Yang ZH, Hu JQ. 2000. Recurrence or metastasis of HCC: Predictors, early detection and experimental antiangiogenic therapy. World J Gastroenterol 6:61-65.
18. Kessenbrock K, Plaks V, Werb Z. 2010. Matrix metalloproteinases: Regulators of the tumor microenvironment. Cell 141:52-67.
19. Kuyvenhoven JP, van Hoek B, Blom E, van Duijn W, Hanemaaijer R, Verheijen JH, Lamers CB, Verspaget HW. 2003. Assessment of the clinical significance of serum matrix metalloproteinases MMP-2 and MMP-9 in patients with various chronic liver diseases and hepatocellular carcinoma. Thromb Haemost 89:718-725.
20. Maatta M, Soini Y, Liakka A, Autio-Harmainen H. 2000. Differential expression of matrix metalloproteinase (MMP)-2, MMP-9, and membrane type 1-MMP in hepatocellular and pancreatic adenocarcinoma: Implications for tumor progression and clinical prognosis. Clin Cancer Res 6:2726-2734.
21. Matsumoto E, Nakatsukasa H, Nouso K, Nakamura SI, Suzuki M, Kobayashi Y, Uemura M, Sato S, Yumoto EI, Yokoyama J, Tsuboi S, Tanaka H, Takuma Y, Fujikawa T, Shiratori Y. 2004. Elevated levels of tissue inhibitor of metalloproteinases (TIMPS) in human hepatocellular carcinomas. Comp Hepatol 3:S51.
22. McKenna GJ, Chen Y, Smith RM, Meneghetti A, Ong C, McMaster R, Scudamore CH, Chung SW. 2002. A role for matrix metalloproteinases and tumor host interaction in hepatocellular carcinomas. Am J Surg 183:588-594.
23. Menne S, Cote PJ. 2007. The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection. World J Gastroenterol 13:104-124.
24. Monga SPS, editor. 2011. Molecular pathology of liver diseases. Heidelberg: Springer. xxiii, 931 p.
25. Ou DP, Tao YM, Tang FQ, Yang LY. 2007. The hepatitis B virus X protein promotes hepatocellular carcinoma metastasis by upregulation of matrix metalloproteinases. Int J Cancer 120:1208-1214.
26. Qin LX, Tang ZY. 2002. The prognostic molecular markers in hepatocellular carcinoma. World J Gastroenterol 8:385-392.
27. Rinaudo JA, Gerin JL. 2004. Cross-species hybridization: Characterization of gene expression in woodchuck liver using human membrane arrays. J Med Virol 74:300-313.
28. Roggendorf M, Tolle TK. 1995. The woodchuck: An animal model for hepatitis B virus infection in man. Intervirology 38:100-112.
29. Semela D, Dufour JF. 2004. Angiogenesis and hepatocellular carcinoma. J Hepatol 41:864-880.
30. Tao K, Qian N, Tang Y, Ti Z, Song W, Cao D, Dou K. 2010. Increased expression of a disintegrin and metalloprotease-9 in hepatocellular carcinoma: Implications for tumor progression and prognosis. Jpn J Clin Oncol 40:645-651.
31. Tennant BC, Toshkov IA, Peek SF, Jacob JR, Menne S, Hornbuckle WE, Schinazi RD, Korba BE, Cote PJ, Gerin JL. 2004. Hepatocellular carcinoma in the woodchuck model of hepatitis B virus infection. Gastroenterology 127:S283-S293.
32. Thieringer FR, Maass T, Anthon B, Meyer E, Schirmacher P, Longerich T, Galle PR, Kanzler S, Teufel A. 2012. Liver-specific overexpression of matrix metalloproteinase 9 (MMP-9) in transgenic mice accelerates development of hepatocellular carcinoma. Mol Carcinog 51:439-448.
33. Yang JD, Roberts LR. 2010. Hepatocellular carcinoma: A global view. Nat Rev Gastroenterol Hepatol 7:448-458.
34. Yeh HC, Lin SM, Chen MF, Pan TL, Wang PW, Yeh CT. 2010. Evaluation of serum matrix metalloproteinase (MMP)-9 to MMP-2 ratio as a biomarker in hepatocellular carcinoma. Hepatogastroenterology 57:98-102.
35. Zapico JM, Serra P, Garcia-Sanmartin J, Filipiak K, Carbajo RJ, Schott AK, Pineda-Lucena A, Martinez A, Martin-Santamaria S, de Pascual-Teresa B, Ramos A. 2011. Potent "clicked" MMP2 inhibitors: Synthesis, molecular modeling and biological exploration. Org Biomol Chem 9:4587-4599.