Matrilysin (MMP-7) is a major matrix metalloproteinase upregulated in biliary atresia-associated liver fibrosis

Modern Pathology

Volumn 18, Issue 7, 2005, Pages 941-950

  Huang, Chao Cheng ^a,b   Chuang, Jiin Haur ^a,b   Chou, Ming Huei ^a   Wu, Chia Lin ^b   Chen, Ching Mei ^b   Wang, Chih Chi ^b   Chen, Yaw Sen ^b   Chen, Chao Long ^b   Tai, Ming Hong ^c  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Biliary atresia; In situ hybridization; Liver fibrosis; Matrilysin; Matrix metalloproteinases; Quantitative RT PCR

Indexed keywords

COLLAGENASE 3; GELATINASE A; GELATINASE B; MATRILYSIN; MATRIX METALLOPROTEINASE; PROTEINASE;

AGAR GEL ELECTROPHORESIS; ARTICLE; BILE DUCT ATRESIA; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME REGULATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KUPFFER CELL; LIVER CELL; LIVER FIBROSIS; LIVER TRANSPLANTATION; PORTOENTEROSTOMY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; UPREGULATION; WESTERN BLOTTING;

ADOLESCENT; ADULT; BILIARY ATRESIA; BLOTTING, WESTERN; CHILD; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KUPFFER CELLS; LIVER CIRRHOSIS; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 7; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEVERITY OF ILLNESS INDEX; TIME FACTORS; UP-REGULATION;

EID: 23044478414     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: 10.1038/modpathol.3800374     Document Type: Article

References (42)

1. Perlmutter DH, Shepherd RW. Extrahepatic biliary atresia: a disease or a phenotype? Hepatology 2002;35: 1297-1304.
2. Chen CL, Chen YS, de Villa VH, et al. Minimal blood loss living donor hepatectomy. Transplantation 2000; 69:2580-2586.
3. Jain A, Reyes J, Kashyap R, et al. Long-term survival after liver transplantation in 4,000 consecutive patients at a single center. Ann Surg 2000;232:490-500.
4. Miller CM, Gondolesi GE, Florman S, et al. One hundred nine living donor liver transplants in adults and children: a single-center experience. Ann Surg 2001;234:301-311 discussion 11-12.
5. Bates MD, Bucuvalas JC, Alonso MH, et al. Biliary atresia: pathogenesis and treatment. Semin Liver Dis 1998;18:281-293.
6. Friedman SL, Maher JJ, Bissell DM. Mechanisms and therapy of hepatic fibrosis: report of the AASLD Single Topic Basic Research Conference. Hepatology 2000;32: 1403-1408.
7. Benyon RC, Arthur MJ. Extracellular matrix degradation and the role of hepatic stellate cells. Semin Liver Dis 2001;21:373-384.
8. Faiz Kabir Uddin Ahmed A, Ohtani H, Nio M, et al. In situ expression of fibrogenic growth factors and their receptors in biliary atresia: comparison between early and late stages. J Pathol 2000;192:73-80.
9. Ahmed AF, Nio M, Ohtani H, et al. Clinical significance of c-kit expression in biliary atresia. Pediatr Surg Int 2001;17:601-603.
10. Liu C, Chiu JH, Chin T, et al. Expression of amino-peptidase N in bile canaliculi: a predictor of clinical outcome in biliary atresia and a potential tool to implicate the mechanism of biliary atresia. J Surg Res 2001;100:76-83.
11. Davenport M, Gonde C, Redkar R, et al. Immunohistochemistry of the liver and biliary tree in extrahepatic biliary atresia. J Pediatr Surg 2001;36:1017-1025.
12. Rosensweig JN, Omori M, Page K, et al. Transforming growth factor-beta1 in plasma and liver of children with liver disease. Pediatr Res 1998;44:402-409.
13. Overall CM, Lopez-Otin C. Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nat Rev Cancer 2002;2:657-672.
14. Cursio R, Mari B, Louis K, et al. Rat liver injury after normothermic ischemia is prevented by a phosphinic matrix metalloproteinase inhibitor. FASEB J 2002;16: 93-95.
15. Kobayashi H, Li ZX, Yamataka A, et al. Clinical evaluation of serum levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases as predictors of progressive fibrosis in postoperative biliary atresia patients. J Pediatr Surg 2002;37: 1030-1033.
16. Boeker KH, Haberkorn CI, Michels D, et al. Diagnostic potential of circulating TIMP-1 and MMP-2 as markers of liver fibrosis in patients with chronic hepatitis C. Clin Chim Acta 2002;316:71-81.
17. Lichtinghagen R, Michels D, Haberkorn CI, et al. Matrix metalloproteinase (MMP)-2, MMP-7, and tissue inhibitor of metalloproteinase-1 are closely related to the fibroproliferative process in the liver during chronic hepatitis C. J Hepatol 2001;34:239-247.
18. Walsh KM, Timms P, Campbell S, et al. Plasma levels of matrix metalloproteinase-2 (MMP-2) and tissue inhibitors of metalloproteinases-1 and -2 (TIMP-1 and TIMP-2) as noninvasive markers of liver disease in chronic hepatitis C: comparison using ROC analysis. Dig Dis Sci 1999;44:624-630.
19. Vaillant B, Chiaramonte MG, Cheever AW, et al. Regulation of hepatic fibrosis and extracellular matrix genes by the th response: new insight into the role of tissue inhibitors of matrix metalloproteinases. J Immunol 2001;167:7017-7026.
20. Benyon RC, Iredale JP, Goddard S, et al. Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver. Gastroenterology 1996;110:821-831.
21. Herbst H, Wege T, Milani S, et al. Tissue inhibitor of metalloproteinase-1 and -2 RNA expression in rat and human liver fibrosis. Am J Pathol 1997;150: 1647-1659.
22. Schuppan D, Ruehl M, Somasundaram R, et al. Matrix as a modulator of hepatic fibrogenesis. Semin Liver Dis 2001;21:351-372.
23. Zuo F, Kaminski N, Eugui E, et al. Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans. Proc Natl Acad Sci USA 2002;99:6292-6297.
24. Bezerra JA, Tiao G, Ryckman FC, et al. Genetic induction of proinflammatory immunity in children with biliary atresia. Lancet 2002;360:1653-1659.
25. Chen L, Goryachev A, Sun J, et al. Altered expression of genes involved in hepatic morphogenesis and fibrogenesis are identified by cDNA microarray analysis in biliary atresia. Hepatology 2003;38:567-576.
26. Ferrell L. Liver pathology: cirrhosis, hepatitis, and primary liver tumors. Update and diagnostic problems. Mod Pathol 2000;13:679-704.
27. Huang CC, Qiu JT, Kashima ML, et al. Generation of type-specific probes for the detection of single-copy human papillomavirus by a novel in situ hybridization method. Mod Pathol 1998;11:971-977.
28. Huang CC, Chuang JH, Huang LL, et al. The human Delta-like 1 homologue is implicated in the progression of liver fibrosis in biliary atresia. J Pathol 2004;202:172-179.
29. Ishak KG, Sharp HL. Developmental abnormalities and liver disease in childhood. In: MacSween RNM, Burt AD, Protmann BC, Ishak KG, Scheuer PJ, Anthony PP (eds). Pathology of the liver, 4th edn. Churchill Livingstone: London, 2002, pp 107-154.
30. Roskams TA, Theise ND, Balabaud C, et al. Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers. Hepatology 2004;39:1739-1745.
31. Rojkind M, Greenwel P. Pathophysiology of liver fibrosis. In: Arias IM (ed). The Liver: Biology and Pathobiology, 4th edn. Lippincott Williams & Wilkins: Philadelphia, 2001, pp 721-738.
32. Birkedal-Hansen H, Moore WG, Bodden MK, et al. Matrix metalloproteinases: a review. Crit Rev Oral Biol Med 1993;4:197-250.
33. Saarialho-Kere UK, Crouch EC, Parks WC. Matrix metalloproteinase matrilysin is constitutively expressed in adult human exocrine epithelium. J Invest Dermatol 1995;105:190-196.
34. Busiek DF, Baragi V, Nehring LC, et al. Matrilysin expression by human mononuclear phagocytes and its regulation by cytokines and hormones. J Immunol 1995;154:6484-6491.
35. Wilson CL, Matrisian LM. Matrilysin: an epithelial matrix metalloproteinase with potentially novel functions. Int J Biochem Cell Biol 1996;28:123-136.
36. Dunsmore SE, Saarialho-Kere UK, Roby JD, et al. Matrilysin expression and function in airway epithelium. J Clin Invest 1998;102:1321-1331.
37. Wilson CL, Ouellette AJ, Satchell DP, et al. Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science 1999;286:113-117.
38. McGuire JK, Li Q, Parks WC. Matrilysin (matrix metalloproteinase-7) mediates E-cadherin ectodomain shedding in injured lung epithelium. Am J Pathol 2003;162:1831-1843.
39. Surendran K, Simon TC, Liapis H, et al. Matrilysin (MMP-7) expression in renal tubular damage: association with Wnt4. Kidney Int 2004;65:2212-2222.
40. Boixel C, Fontaine V, Rucker-Martin C, et al. Fibrosis of the left atria during progression of heart failure is associated with increased matrix metalloproteinases in the rat. J Am Coll Cardiol 2003;42:336-344.
41. Lichtinghagen R, Bahr MJ, Wehmeier M, et al. Expression and coordinated regulation of matrix metalloproteinases in chronic hepatitis C and hepatitis C virus-induced liver cirrhosis. Clin Sci (London) 2003; 105:373-382.
42. Westermarck J, Kahari VM. Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J 1999;13:781-792.