6-Acetonyl-5,6-dihydrosanguinarine (ADS) from Chelidonium majus L. triggers proinflammatory cytokine production via ROS-JNK/ERK-NFκB signaling pathway

Food and Chemical Toxicology

Volumn 58, Issue , 2013, Pages 273-279

  Kim, Dong Hyeok ^a   Lee, Ji Hye ^a   Park, Soojong ^a   Oh, Sang seok ^a   Kim, Suk ^a   Kim, Dae Wook ^a   Park, Ki Hun ^a   Kim, Kwang Dong ^a  

^a Gyeongsang National University   (South Korea)

Author keywords

6 Acetonyl 5,6 dihydrosanguinarine; Chelidonium majus; Inflammatory cytokine; MAPK; NF B; ROS

Indexed keywords

6 ACETONYL 5,6 DIHYDROSANGUINARINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOMODULATING AGENT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MONOCYTE CHEMOTACTIC PROTEIN 1; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; SANGUINARINE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHELIDONIUM; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; IMMUNOMODULATION; IMMUNOSTIMULATION; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

6-ACETONYL-5,6-DIHYDROSANGUINARINE; CHELIDONIUM MAJUS; INFLAMMATORY CYTOKINE; MAPK; NFΚB; ROS;

ANIMALS; BENZODIOXOLES; BENZOPHENANTHRIDINES; CELL LINE; CHELIDONIUM; CYTOKINES; INFLAMMATION MEDIATORS; MAP KINASE SIGNALING SYSTEM; MICE; NF-KAPPA B; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84878217279     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.04.051     Document Type: Article

References (35)

1. Belardelli F., Ferrantini M. Cytokines as a link between innate and adaptive antitumor immunity. Trends Immunol. 2002, 23:201-208.
2. Chen B.C., Lin W.W. PKC- and ERK-dependent activation of I kappa B kinase by lipopolysaccharide in macrophages: enhancement by P2Y receptor-mediated CaMK activation. Br. J. Pharmacol. 2001, 134:1055-1065.
3. Chung H.S., An H.J., Jeong H.J., Won J.H., Hong S.H., Kim H.M. Water extract isolated from Chelidonium majus enhances nitric oxide and tumour necrosis factor-alpha production via nuclear factor-kappaB activation in mouse peritoneal macrophages. J. Pharm. Pharmacol. 2004, 56:129-134.
4. Colombo M.L., Bosisio E. Pharmacological activities of Chelidonium majus L. (Papaveraceae). Pharmacol. Res. 1996, 33:127-134.
5. Cordes N., Plasswilm L., Bamberg M., Rodemann H.P. Ukrain, an alkaloid thiophosphoric acid derivative of Chelidonium majus L. protects human fibroblasts but not human tumour cells in vitro against ionizing radiation. Int. J. Radiat. Biol. 2002, 78:17-27.
6. Ernst E., Schmidt K. Ukrain - a new cancer cure? A systematic review of randomised clinical trials. BMC Cancer 2005, 5:69.
7. Gilca M., Gaman L., Panait E., Stoian I., Atanasiu V. Chelidonium majus - an integrative review: traditional knowledge versus modern findings. Forsch Komplementmed 2010, 17:241-248.
8. Harris G.K., Shi X. Signaling by carcinogenic metals and metal-induced reactive oxygen species. Mutat. Res. 2003, 533:183-200.
9. Hsieh I.N., Chang A.S., Teng C.M., Chen C.C., Yang C.R. Aciculatin inhibits lipopolysaccharide-mediated inducible nitric oxide synthase and cyclooxygenase-2 expression via suppressing NF-kappaB and JNK/p38 MAPK activation pathways. J. Biomed. Sci. 2011, 18:28.
10. Huang, J., Lam, G.Y., Brumell, J.H., 2011. Autophagy signaling through reactive oxygen species. Antioxid Redox Signal 14, 2215-2231.
11. Joffre O., Nolte M.A., Sporri R., Reis e Sousa C. Inflammatory signals in dendritic cell activation and the induction of adaptive immunity. Immunol. Rev. 2009, 227:234-247.
12. Johnson G.L., Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002, 298:1911-1912.
13. Kabe Y., Ando K., Hirao S., Yoshida M., Handa H. Redox regulation of NF-kappaB activation: distinct redox regulation between the cytoplasm and the nucleus. Antioxid. Redox Signal. 2005, 7:395-403.
14. Karin M., Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu. Rev. Immunol. 2000, 18:621-663.
15. Koul S., Razdan T.K., Andotra C.S., Kalla A.K., Koul S., Taneja S.C. Benzophenanthridine alkaloids from Corydalis flabellata. Planta Med. 2002, 68:262-265.
16. Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb. Perspect. Biol. 2009, 1:a001651.
17. Lee S., Kim Y.J., Kwon S., Lee Y., Choi S.Y., Park J., Kwon H.J. Inhibitory effects of flavonoids on TNF-alpha-induced IL-8 gene expression in HEK 293 cells. BMB Rep. 2009, 42:265-270.
18. Lin W.W., Karin M. A cytokine-mediated link between innate immunity, inflammation, and cancer. J. Clin. Invest. 2007, 117:1175-1183.
19. Liu X., Silverstein P.S., Singh V., Shah A., Qureshi N., Kumar A. Methamphetamine increases LPS-mediated expression of IL-8, TNF-alpha and IL-1beta in human macrophages through common signaling pathways. PLoS One 2012, 7:e33822.
20. Lutz M.B., Kukutsch N., Ogilvie A.L., Rossner S., Koch F., Romani N., Schuler G. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods 1999, 223:77-92.
21. Matsuzawa A., Ichijo H. Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling. Biochim. Biophys. Acta 2008, 1780:1325-1336.
22. Meng F., Zuo G., Hao X., Wang G., Xiao H., Zhang J., Xu G. Antifungal activity of the benzo[c]phenanthridine alkaloids from Chelidonium majus Linn against resistant clinical yeast isolates. J. Ethnopharmacol. 2009, 125:494-496.
23. Morgan M.J., Liu Z.G. Crosstalk of reactive oxygen species and NF-kappaB signaling. Cell Res. 2010, 21:103-115.
24. Naik E., Dixit V.M. Mitochondrial reactive oxygen species drive proinflammatory cytokine production. J. Exp. Med. 2011, 208:417-420.
25. Paludan S.R. Synergistic action of pro-inflammatory agents: cellular and molecular aspects. J. Leukocyte Biol. 2000, 67:18-25.
26. Park J.E., Cuong T.D., Hung T.M., Lee I., Na M., Kim J.C., Ryoo S., Lee J.H., Choi J.S., Woo M.H., Min B.S. Alkaloids from Chelidonium majus and their inhibitory effects on LPS-induced NO production in RAW264.7 cells. Bioorg. Med. Chem. Lett. 2011, 21:6960-6963.
27. Pencikova K., Kollar P., Muller Zavalova V., Taborska E., Urbanova J., Hosek J. Investigation of sanguinarine and chelerythrine effects on LPS-induced inflammatory gene expression in THP-1 cell line. Phytomedicine 2012, 19:890-895.
28. Shimizu S., Tahara M., Ogata S., Hashimoto K., Morishige K., Tasaka K., Murata Y. Involvement of nuclear factor-kB activation through RhoA/Rho-kinase pathway in LPS-induced IL-8 production in human cervical stromal cells. Mol. Hum. Reprod. 2007, 13:181-187.
29. Song J.Y., Yang H.O., Pyo S.N., Jung I.S., Yi S.Y., Yun Y.S. Immunomodulatory activity of protein-bound polysaccharide extracted from Chelidonium majus. Arch. Pharm. Res. 2002, 25:158-164.
30. Takada Y., Mukhopadhyay A., Kundu G.C., Mahabeleshwar G.H., Singh S., Aggarwal B.B. Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase. J. Biol. Chem. 2003, 278:24233-24241.
31. Torres M., Forman H.J. Redox signaling and the MAP kinase pathways. Biofactors 2003, 17:287-296.
32. Ueda S., Masutani H., Nakamura H., Tanaka T., Ueno M., Yodoi J. Redox control of cell death. Antioxid. Redox Signal. 2002, 4:405-414.
33. Viatour P., Merville M.P., Bours V., Chariot A. Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation. Trends Biochem. Sci. 2005, 30:43-52.
34. Zhang X., Goncalves R., Mosser D.M. The isolation and characterization of murine macrophages. Curr. Protoc. Immunol. 2008, Chapter 14, Unit 14 11.
35. Zuo G.Y., Meng F.Y., Hao X.Y., Zhang Y.L., Wang G.C., Xu G.L. Antibacterial alkaloids from Chelidonium majus Linn (papaveraceae) against clinical isolates of methicillin-resistant Staphylococcus aureus. J. Pharm. Pharm. Sci. 2008, 11:90-94.