Ligand binding reduces conformational flexibility in the active site of tyrosine phosphatase related to biofilm formation A (TpbA) from pseudomonas aeruginosa

Journal of Molecular Biology

Volumn 425, Issue 12, 2013, Pages 2219-2231

  Koveal, Dorothy ^a   Clarkson, Michael W ^b   Wood, Thomas K ^c   Page, Rebecca ^a   Peti, Wolfgang ^b,d  

^a BROWN UNIVERSITY   (United States)

^b BROWN UNIVERSITY   (United States)

^c The Pennsylvania State University   (United States)

^d BROWN UNIVERSITY   (United States)

Author keywords

bacterial signaling; dual specificity phosphatase; NMR spectroscopy; open closed state active site dynamics; Pseudomonas aeruginosa

Indexed keywords

PROTEIN TYROSINE PHOSPHATASE;

ARTICLE; BIOFILM; CELL FUNCTION; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; GEL PERMEATION CHROMATOGRAPHY; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HYDROGEN BOND; LIGAND BINDING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRECIPITATION; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN SECONDARY STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA;

BACTERIA (MICROORGANISMS); EUKARYOTA; PROKARYOTA; PSEUDOMONAS AERUGINOSA;

EID: 84878217023     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2013.03.023     Document Type: Article

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