OCT4 is epigenetically regulated by DNA hypomethylation of promoter and exon in primary gliomas

Oncology Reports

Volumn 30, Issue 1, 2013, Pages 201-206

  Shi, Jinlong ^a   Shi, Wei ^a   Ni, Lanchun ^a   Xu, Xide ^a   Su, Xing ^a   Xia, Liang ^a   Xu, Feng ^b   Chen, Jian ^a   Zhu, Jianhong ^b  

^a NANTONG UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Glioma; Hypomethylation; OCT4

Indexed keywords

DNA; MESSENGER RNA; OCTAMER TRANSCRIPTION FACTOR 4;

ARTICLE; CANCER GRADING; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DNA METHYLATION; EPIGENETICS; EXON; GENE EXPRESSION REGULATION; GLIOMA; GLIOMA CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; OCT4 GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

CELL DIFFERENTIATION; CELL LINE, TUMOR; DNA METHYLATION; EMBRYONIC STEM CELLS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLIOMA; HUMANS; NEURAL STEM CELLS; OCTAMER TRANSCRIPTION FACTOR-3; PROMOTER REGIONS, GENETIC; REGULATORY SEQUENCES, NUCLEIC ACID;

EID: 84878212459     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2456     Document Type: Article

References (42)

1. Bondy ML, Scheurer ME, Malmer B, et al: Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium. Cancer 113: 1953-1968, 2008.
2. Yuan X, Curtin J, Xiong Y, et al: Isolation of cancer stem cells from adult glioblastoma multiforme. Oncogene 23: 9392-9400, 2004. (Pubitemid 40069671)
3. Galli R, Binda E, Orfanelli U, et al: Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 64: 7011-7021, 2004. (Pubitemid 39331011)
4. Singh SK, Hawkins C, Clarke ID, et al: Identification of human brain tumour initiating cells. Nature 432: 396-401, 2004. (Pubitemid 39551674)
5. Hemmati HD, Nakano I, Lazareff JA, et al: Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci USA 100: 15178-15183, 2003. (Pubitemid 37518036)
6. Schöler H, Ruppert S, Suzuki N, et al: New type of POU domain in germ line-specific protein Oct-4. Nature 344: 435- 439, 1990.
7. Pesce M and Schöler HR: Oct-4: gatekeeper in the beginnings of mammalian development. Stem Cells 19: 271-278, 2001. (Pubitemid 32721093)
8. Takeda J, Seino S and Bell GT: Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. Nucleic Acids Res 20: 4613-4620, 1992.
9. Babaie Y, Herwig R, Greber B, et al: Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells. Stem Cells 25: 500-510, 2007. (Pubitemid 46232806)
10. Webster JD, Yuzbasiyan-Gurkan V, Trosko JE, et al: Expression of the embryonic transcription factor Oct4 in canine neoplasms: a potential marker for stem cell subpopulations in neoplasia. Vet Pathol 44: 893-900, 2007. (Pubitemid 350260709)
11. Chiou SH, Yu CC, Huang CY, et al: Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma. Clin Cancer Res 14: 4085-4095, 2008.
12. Du Z, Jia D, Liu S, et al: Oct4 is expressed in human gliomas and promotes colony formation in glioma cells. Glia 57: 724-733, 2009.
13. Holmberg J, He X, Peredo I, et al: Activation of neural and pluripotent stem cell signatures correlates with increased malignancy in human glioma. PloS One 6: e18454, 2011.
14. Ben-Porath I, Thomson MW, Carey VJ, et al: An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 40: 499-507, 2008. (Pubitemid 351601215)
15. Ellis L, Atadja PW and Johnstone RW: Epigenetics in cancer: targeting chromatin modifications. Mol Cancer Ther 8: 1409-1420, 2009.
16. Baylin SB and Herman JG: DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 16: 168-174, 2000. (Pubitemid 30169152)
17. Ehrich M, Turner J, Gibbs P, et al: Cytosine methylation profiling of cancer cell lines. Proc Natl Acad Sci USA 105: 4844-4849, 2008. (Pubitemid 351753834)
18. Jones PA: Epigenetics in carcinogenesis and cancer prevention. Ann NY Acad Sci 983: 213-219, 2003.
19. Feinberg AP: Cancer epigenetics takes center stage. Proc Natl Acad Sci USA 98: 392-394, 2001.
20. Nagarajan RP and Costello JF: Molecular epigenetics and genetics in neuro-oncology. Neurotherapeutics 6: 436-446, 2009.
21. Shi G and Jin Y: Role of Oct4 in maintaining and regaining stem cell pluripotency. Stem Cell Res Ther 1: 39, 2010.
22. Feldman N, Gerson A, Fang J, et al: G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Nat Cell Biol 8: 188-194, 2006.
23. Deb-Rinker P, Ly D, Jezierski A, et al: Sequential DNA methylation of the Nanog and Oct-4 upstream regions in human NT2 cells during neuronal differentiation. J Biol Chem 280: 6257- 6260, 2005.
24. Gidekel S and Bergman Y: A unique developmental pattern of Oct-3/4 DNA methylation is controlled by a cis-demodification element. J Biol Chem 277: 34521-34530, 2002.
25. Hattori N, Nishino K, Ko YG, et al: Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells. J Biol Chem 279: 17063-17069, 2004. (Pubitemid 38560461)
26. Xue WC, Chan KY, Feng HC, et al: Promoter hypermethylation of multiple genes in hydatidiform mole and choriocarcinoma. J Mol Diagn 6: 326-334, 2004. (Pubitemid 39517400)
27. Liao X, Siu MK, Chan KY, et al: Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis. Int J Cancer 123: 296-302, 2008. (Pubitemid 351842013)
28. Nordhoff V, Hübner K, Bauer A, et al: Comparative analysis of human, bovine, and murine Oct-4 upstream promoter sequences. Mamm Genome 12: 309-317, 2001. (Pubitemid 32242892)
29. Singh SK, Clarke ID, Terasaki M, et al: Identification of a cancer stem cell in human brain tumors. Cancer Res 63: 5821-5828, 2003. (Pubitemid 37187480)
30. Singh SK, Clarke ID, Hide T and Dirks PB: Cancer stem cells in nervous system tumors. Oncogene 23: 7267-7273, 2004. (Pubitemid 39382160)
31. Sathomsumetee S, Reardon DA, Desjardins A, et al: Molecularly targeted therapy for malignant glioma. Cancer 110: 13-24, 2007.
32. Gidekel S, Pizov G, Bergman Y and Pikarsky E: Oct-3/4 is a dose-dependent oncogenic fate determinant. Cancer Cell 4: 361- 370, 2003.
33. Yeom YI, Fuhrmann G, Ovitt CE, et al: Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells. Development 122: 881- 894, 1996.
34. Ben-Shushan E, Pikarsky E, Klar A and Bergman Y: Extinction of Oct-3/4 gene expression in embryonal carcinoma x fibroblast somatic cell hybrids is accompanied by changes in the methylation status, chromatin structure, and transcriptional activity of the Oct-3/4 upstream region. Mol Cell Biol 13: 891-901, 1993. (Pubitemid 23040254)
35. Simonsson S and Gurdon J: DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei. Nat Cell Biol 6: 984-990, 2004. (Pubitemid 39359851)
36. Tsuji-Takayama K, Inoue T, Ijiri Y, et al: Demethylating agent, 5-azacytidine, reverses differentiation of embryonic stem cells. Biochem Biophys Res Commun 323: 86-90, 2004. (Pubitemid 39200653)
37. Cantz T, Key G, Bleidissel M, et al: Absence of OCT4 expression in somatic tumor cell lines. Stem Cells 26: 692-697, 2008.
38. Zhang HJ, Siu MK, Wong ES, et al: Oct4 is epigenetically regulated by methylation in normal placenta and gestational trophoblastic disease. Placenta 29: 549-554, 2008.
39. Hoffmann MJ, Müller M, Engers R and Schulz WA: Epigenetic control of CTCFL/BORIS and OCT4 expression in urogenital malignancies. Biochem Pharmacol 72: 1577-1588, 2006. (Pubitemid 44666737)
40. Ehrlich M: DNA methylation in cancer: too much, but also too little. Oncogene 21: 5400-5413, 2002.
41. Fanelli M, Caprodossi S, Ricci-Vitiani L, et al: Loss of pericentromeric DNA methylation pattern in human glioblastoma is associated with altered DNA methyltransferases expression and involves the stem cell compartment. Oncogene 27: 358-365, 2008.
42. Cadieux B, Ching TT, VandenBerg SR and Costello JF: Genome-wide hypomethylation in human glioblastomas associated with specific copy number alteration, methylenetetrahydrofolate reductase allele status, and increased proliferation. Cancer Res 66: 8469-8476, 2006. (Pubitemid 44449159)