Different host cell proteases activate the SARS-coronavirus spike-protein for cell-cell and virus-cell fusion

Virology

Volumn 413, Issue 2, 2011, Pages 265-274

  Simmons, Graham ^a   Bertram, Stephanie ^b   Glowacka, Ilona ^b   Steffen, Imke ^b   Chaipan, Chawaree ^c   Agudelo, Juliet ^a   Lu, Kai ^a   Rennekamp, Andrew J ^d   Hofmann, Heike ^c,e   Bates, Paul ^d   Pöhlmann, Stefan ^b,f  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e UNIVERSITY OF KIEL   (Germany)

^f GERMAN PRIMATE CENTER   (Germany)

Author keywords

Cathepsin l; Furin; Proteolytic cleavage; SARS coronavirus; Spike protein

Indexed keywords

CATHEPSIN L; FURIN; PROTEINASE; SARS CORONAVIRUS SPIKE PROTEIN; TRYPSIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CELL FUSION; CELL STRAIN HEK293; CONTROLLED STUDY; HOST CELL; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; SARS CORONAVIRUS; SITE DIRECTED MUTAGENESIS; VIRUS CELL INTERACTION; VIRUS MUTATION;

CELL FUSION; CELL LINE; FURIN; GENE EXPRESSION REGULATION, VIRAL; HUMANS; LEUPEPTINS; MUTATION; PEPTIDE HYDROLASES; SARS VIRUS; TRYPSIN; VIRUS INTERNALIZATION;

SARS CORONAVIRUS;

EID: 79954628858     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2011.02.020     Document Type: Article

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