Cadmium inhibits the ovary δ-aminolevulinate dehydratase activity in vitro and ex vivo: Protective role of seleno-furanoside

Journal of Applied Toxicology

Volumn 33, Issue 7, 2013, Pages 679-684

  Vargas, Laura Musacchio ^a   Soares, Melina Bucco ^a   Izaguirry, Aryele Pinto ^a   Lüdtke, Diogo Seibert ^b,c   Braga, Hugo C ^b   Savegnago, Lucielli ^d   Wollenhaupt, Suzi ^a   Brum, Daniela Dos Santos ^a   Leivas, Fábio Gallas ^a   Santos, Francielli Weber ^a  

^a UNIVERSIDADE FEDERAL DO PAMPA   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d FEDERAL UNIVERSITY OF PELOTAS   (Brazil)

Author keywords

ALA D; Cadmium; Mice; Ovary; Seleno furanoside

Indexed keywords

CADMIUM; ORGANOSELENIUM DERIVATIVE; PORPHOBILINOGEN SYNTHASE; PROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COW; DRUG INHIBITION; ENZYME ACTIVITY; EX VIVO STUDY; FEMALE; IC 50; IN VITRO STUDY; MOUSE; NONHUMAN; OVARY; PRIORITY JOURNAL; PROTECTION;

ANIMALS; ANTIOXIDANTS; CADMIUM CHLORIDE; CATTLE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; FEMALE; MICE; ORGANOSELENIUM COMPOUNDS; OVARY; OXIDATION-REDUCTION; PENTOSES; PORPHOBILINOGEN SYNTHASE; PROTEIN BIOSYNTHESIS;

BOVINAE; MUS; NICOTIANA TABACUM;

EID: 84878200014     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.2783     Document Type: Article

References (46)

1. ATSDR. 1999. Toxicological profile of cadmium. Agency for Toxic Substances and Disease Registry.
2. Bechara EJH, Medeiros MHG, Monteiro HP, Hermes-Lima M, Pereira B, Demasi M, Acosta CA, Abdalla DSP, Onuki J, Wendel CAM, Di Mascio P. 1993. A free radical hypothesis of lead poisoning and inborn porphyries associated with 5-aminolevulinic acid overload. Química Nova 16: 385-392.
3. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principles of protein-dye binding. Anal. Biochem. 72: 248-254.
4. Braga HC, Stefani HA, Paixão MW, Santos FW, Lüdtke DS. 2010. Synthesis of 5′-seleno-xylofuranosides. Tetrahedron 66: 3441-3446.
5. Brandão R, Olveira R, Nogueira CW. 2010. Association between diphenyl diselenide and cadmium chloride attenuates the toxicity of both in tissues of mice in vitro. Toxicol. In Vitro 26: 1736-1742.
6. Brandão R, Santos FW, Oliveira R, Roman SS, Nogueira CW. 2009. Involvement of non-enzymatic antioxidant defenses in the protective effect of diphenyl diselenide on testicular damage induced by cadmium in mice. J. Trace Elem. Med. Biol. 23: 324-333.
7. +-ATPase activities in rat brain homogenates in vitro. Mol. Cell. Biochem. 332: 17-24.
8. Brzóska MM, Rogalska J, Kupraszewicz E. 2011. The involvement of oxidative stress in the mechanisms of damaging cadmium action in bone tissue: A study in a rat model of moderate and relatively high human exposure. Toxicol. Appl. Pharmacol. 250: 327-335.
9. Douki T, Onuki J, Medeiros MHG, Bechara EJH, Cadet J, Di Mascio P. 1998. Hydroxyl radicals are involved in the oxidation of isolated and cellular DNA bases by 5-aminolevulinic acid. FEBS Lett. 428: 93-96.
10. El-Demerdash FM, Yousef MI, Kedwany FS, Baghdadi HH. 2004. Cadmium-induced changes in lipid peroxidation, blood haematology, biochemical parameters and semen quality of male rats: protective role of vitamin E and β-carotene. Food Chem. Toxicol. 42: 1563-1571.
11. Emanuelli T, Pagel FW, Alves LB, Regner A, Souza DO. 2001. Inhibition of adenylate cyclase activity by 5-aminolevulinic acid in rat and human brain. Neurochem. Int. 38: 213-218.
12. Farina M, Folmer V, Andrade LH, Zeni G, Bolzan RC, Braga AL, Rocha JBT. 2001. Selenoxides inhibits δ-aminolevulinic acid dehydratase. Toxicol. Lett. 119: 27-37.
13. Flora SJS, Dubey R, Kannan GM, Chauhan RS, Pant BP, Jaiswal DK. 2002. Meso 2, 3-dimercaptosuccinic acid (DMSA) and monoysoamyl DMSA effect on gallium arsenide induced pathological liver injury in rats. Toxicol. Lett. 132: 9-17.
14. Gibson KD, Neuberger A, Scott JJ. 1955. The purification and properties of delta-aminolevulinic acid dehydratase. Biochem. J. 61: 618-628.
15. Gonçalves JF, Fiorenza AM, Spanevello RM, Mazzanti CM, Bochi GV, Antes FG, Stefanello N, Rubin MA, Dressler VL, Morsch VM, Schetinger MRC. 2010. N-acetylcysteine prevents memory deficits, the decrease in acetylcholinesterase activity and oxidative stress in rats exposed to cadmium. Chem. Biol. Interact. 186: 53-60.
16. Jaffe EK, Ali S, Mitchell LW, Taylor KM, Volin M, Markham GD. 1995. Characterization of the role of the stimulatory magnesium of Escherichia coli porphobilinogen syntase. Biochemistry 34: 244-251.
17. Kumar N, Garga AK, Dassa RS, Chaturvedi VK, Mudgal V, Varshney VP. 2009. Selenium supplementation influences growth performance, antioxidant status and immune response in lambs. Anim. Feed Sci. Technol. 153: 77-87. DOI: 10.1016/j.anifeedsci.2009.06.007
18. Le Guevel R, Petit FG, Le Goff P, Metivier R, Valotaire Y, Pakdel F. 2000. Inhibition of rainbow trout (Oncorhincus mykiss) estrogen receptor activity by cadmium. Biol. Reprod. 63: 256-259.
19. Leoni G, Bogliolo L, Deiana G, Berlinguer F, Rosati I, Pintus PP, Ledda S, Naitana S. 2002. Influence of cadmium exposure on in vitro ovine gamete dysfunction. Reprod. Toxicol. 16: 371-377.
20. Luchese C, Zeni G, Rocha JBT, Nogueira CW, Santos FW. 2007. Cadmium inhibits δ-aminolevulinate dehydratase from rat lung in vitro: Interaction with chelating and antioxidant agents. Chem. Biol. Interact. 165: 127-137.
21. Neal R, Yang P, Fiechtl J, Yildiz D, Gurer H, Ercal N. 1997. Pro-oxidant effects of 6 -aminolevulinic acid (δ-ALA) on Chinese hamster ovary (CHO) cells. Toxicol. Lett. 91: 169-178.
22. Nicolaou KC, Petasis NA. 1984. Selenium in Natural Products Synthesis. CIS, Inc., Philadelphia, PA.
23. Nogueira CW, Soares FA, Nascimento PC, Muller D, Rocha JBT. 2003a. 2, 3-Dimercaptopropane-1-sulfonic acid and meso-2, 3-dimercaptosiccinic acid increase mercury and cadmium-induced inhibition of δ-aminolevulinate dehydratase. Toxicology 184: 85-95.
24. Nogueira CW, Meotti FC, Curte E, Pilissão C, Zeni G, Rocha JBT. 2003b. Investigations into the potential neurotoxicity induced by diselenides in mice and rats. Toxicology 183: 29-37.
25. Ognjanovic BI, Markovic SD, Dordevic NZ, Trbojevic IS, Stajn AS, Saicic ZS. 2010. Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: Protective role of coenzyme Q10 and Vitamin E. Reprod. Toxicol. 29: 191-197.
26. Paksy K, Rajczy K, Forgacs Z, Lazar P, Bernard A, Gaiti I. 1997. Effect of cadmium on morphology and steroidogenesis of cultured human ovarian granulosa cells. J. Appl. Toxicol. 17: 321-327.
27. 2 on porphobilinogen-synthase (E.C. 4.2.1.24) activity and on mercury levels in rats exposed during different precocious periods of postnatal life. Cell Biol. Int. 31: 1057-1062.
28. Piasek M, Blanua M, Kostial K, Laskey JW. 2001. Placental cadmium and progesterone concentrations in cigarette smokers. Reprod. Toxicol. 15: 673-681.
29. Santos FW, Oro T, Zeni G, Rocha JBT, Nascimento PC, Nogueira CW. 2004. Cadmium induced testicular damage and its response to administration of succimer and diphenyl diselenide in mice. Toxicol. Lett. 152: 255-263.
30. Santos FW, Rocha JBT, Nogueira CW. 2006. 2, 3-Dimercaptopropanol, 2, 3-dimercaptopropane-1-sulfonic acid and meso-2, 3-dimercaptosiccinic acid increase lead-induced inhibition of δ-aminolevulinate dehydratase in vitro and ex vivo. Toxicol. In Vitro 20: 317-323. DOI: 10.1016/j.tiv.2005.08.006
31. Santos FW, Zeni G, Rocha JBT, Nascimento PC, Marques MS, Nogueira CW. 2005a. Efficacy of 2, 3-dimercapto-1-propanesulfonic acid (DMPS) and diphenyl diselenide on cadmium induced testicular damage in mice. Food Chem. Toxicol. 43: 1723-1730.
32. Santos FW, Zeni G, Rocha JBT, Weis SN, Fachinetto JM, Favero AM, Nogueira CW. 2005b. Diphenyl diselenide reverses cadmium-induced oxidative damage on mice tissues. Chem. Biol. Interact. 151: 159-165.
33. Sassa S. 1982. Delta-aminolevulinic acid dehydratase assay. Enzyme 28: 133-145.
34. Satarug S, Moore MR. 2004. Adverse health effects of chronic exposure to low-level cadmium in foodstuffs and cigarette smoke. Environ. Health Perspect. 112: 1099-1103.
35. Shamberger RJ. 1983. Biochemistry of Selenium. Plenum: New York, NY.
36. Sharara FI, Seifer DB, Flaws JA. 1998. Environmental toxicants and female reproduction. Fert. Ster. 70: 613-622.
37. Stohs SJ, Bagchi D. 1995. Oxidative mechanisms in the toxicity of metal ions. Free Radic. Biol. Med. 18: 321-336.
38. Tandon SK, Singh S, Prasad S, Srivastava S, Siddiqui MKJ. 2002. Reversal of lead-induced oxidative stress by chelating agent, antioxidant, or their combination in the rat. Environ. Res. Sect. A 90: 61-66.
39. Thompson J, Bannigan J. 2008. Cadmium: Toxic effects on the reproductive system and the embryo. Reprod. Toxicol. 25: 304-315.
40. Varga B, Zsolnai B, Paksy K, Náray M, Ungváry G. 1993. Age dependent accumulation of cadmium in the human ovary. Reprod. Toxicol. 7: 225-228.
41. Wang G, Fowler BA. 2008. Roles of Biomarkers nin evaluating interactions among mixtures of lead, cadmium and arsenic. Toxicol. Appl. Pharmacol. 233: 92-99.
42. Wang Q, Ye LX, Zhao HH, Chen JW, Zhou YK. 2011. Benchmark dose approach for low-level lead induced haematogenesis inhibition and associations of childhood intelligences with ALAD activity and ALA levels. Sci. Total Environ. 409: 1806-1810.
43. Yalin S, Comelekoglu U, Bagis S, Sahin NO, Ogenler O, Hatungil R. 2006. Acute effect of single-dose cadmium treatment on lipid peroxidation and antioxidant enzymes in ovariectomized rats. Ecotoxicol. Environ. Saf. 65: 140-144.
44. Yang K, Julan L, Rubio F. 2006. Cadmium reduces 11- hydroxysteroid dehydrogenase type 2 activity and expression in human placental trophoblast cells. Am. J. Physiol. Endocrinol. Metab. 290: E135-E142.
45. Zhang W, Pang F, Huang Y, Yan P, Lin W. 2008. Cadmium exerts toxic effects on ovarian steroid hormone release in rats. Toxicol. Lett. 182: 18-23.
46. Zhang W, Yang J, Wang J, Xia P, Xu Y, Jia H, Chen Y. 2007. Comparative studies on the increase of uterine weight and related mechanisms of cadmium and p-nonylphenol. Toxicology 241: 84-91.