Antioxidant and anti-inflammatory effects of Astragalus polysaccharide on EA.hy926 cells

Experimental and Therapeutic Medicine

Volumn 6, Issue 1, 2013, Pages 199-203

  Huang, Wei Min ^a   Liang, Yong Qi ^a   Tang, Li Jun ^a   Ding, Yue ^a   Wang, Xiao Hong ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Astragalus polysaccharide; Bronchopulmonary dysplasia; Inflammatory response; Oxidative stress

Indexed keywords

ASTRAGALUS POLYSACCHARIDE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 8; MALONALDEHYDE; POLYSACCHARIDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; HUMAN; HYPEROXIA; LIPID PEROXIDATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION; WESTERN BLOTTING;

EID: 84878187445     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2013.1074     Document Type: Article

References (34)

1. Jobe AH: The new bronchopulmonary dysplasia. Curr Opin Pediatr 23: 167-172, 2011.
2. Joung KE, Kim HS, Lee J, et al: Correlation of urinary inflammatory and oxidative stress markers in very low birth weight infants with subsequent development of bronchopulmonary dysplasia. Free Radic Res 45: 1024-1032, 2011.
3. Gien J and Kinsella JP: Pathogenesis and treatment of bronchopulmonary dysplasia. Curr Opin Pediatr 23: 305-313, 2011.
4. Fernandez-Gonzalez A, Alex Mitsialis S, Liu X and KourembanasS: Vasculoprotective effects of heme oxygenase-1 in a murine model of hyperoxia-induced bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol 302: L775-L784, 2012.
5. Doyle LW, Ehrenkranz RA and Halliday HL: Postnatal hydrocortisone for preventing or treating bronchopulmonary dysplasia in preterm infants: a systematic review. Neonatology 98: 111-117, 2010.
6. Needelman H, Evans M, Roberts H, Sweney M and BodensteinerJB: Effects of postnatal dexamethasone exposure on the developmental outcome of premature infants. J Child Neurol 23: 421-424, 2008.
7. Jobe AH: Postnatal corticosteroids for bronchopulmonary dysplasia. Clin Perinatol 36: 177-188, 2009.
8. Shao BM, Xu W, Dai H, Tu P, Li Z and Gao XM: A study on the immune receptors for polysaccharides from the roots of Astragalus membranaceus, a Chinese medicinal herb. Biochem Biophys Res Commun 320: 1103-1111, 2004.
9. Zhang BQ, Hu SJ, Qiu LH, et al: Effects of Astragalus membranaceus and its main components on the acute phase endothelial dysfunction induced by homocysteine. Vascul Pharmacol 46: 278-285, 2007.
10. Yang M, Qian XH, Zhao DH and Fu SZ: Effects of Astragalus polysaccharide on the erythroid lineage and microarray analysis in K562 cells. J Ethnopharmacol 127: 242-250, 2010.
11. Gao XH, Xu XX, Pan R, et al: Saponin fraction from Astragalus membranaceus roots protects mice against polymicrobial sepsis induced by cecal ligation and puncture by inhibiting inflammation and upregulating protein C pathway. J Nat Med 63: 421-429, 2009.
12. Xu D, Perez RE, Ekekezie II, Navarro A and Truog WE: Epidermal growth factor-like domain 7 protects endothelial cells from hyperoxia-induced cell death. Am J Physiol Lung Cell Mol Physiol 294: L17-L23, 2008.
13. Song YH, Neumeister MW, Mowlavi A and Suchy H: Tumor necrosis factor-alpha and lipopolysaccharides induce differentially interleukin 8 and growth related oncogene-alpha expression in human endothelial cell line EA. hy926. Ann Plast Surg 45: 681-683, 2000.
14. Thornhill MH, Li J and Haskard DO: Leucocyte endothelial cell adhesion: a study comparing human umbilical vein endothelial cells and the endothelial cell line EA-hy-926. Scand J Immunol38: 279-286, 1993.
15. Jones MK, Sarfeh IJ and Tarnawski AS: Induction of in vitro angiogenesis in the endothelial-derived cell line, EA. hy926, by ethanol is mediated through PKC and MAPK. Biochem Biophys Res Commun 249: 118-123, 1998.
16. Huang J, de Paulis T and May JM: Antioxidant effects of dihydrocaffeic acid in human EA. hy926 endothelial cells. J Nutr Biochem 15: 722-729, 2004.
17. Aranda E and Owen GI: A semi-quantitative assay to screen for angiogenic compounds and compounds with angiogenic potential using the EA. hy926 endothelial cell line. Biol Res 42: 377-389, 2009.
18. Yu C, Liu X and Zhang Y: Effects of fluid shear stress on the expression of IL-8 receptor mRNA in EA. Hy926 cells. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 24: 303-307, 2007 (In Chinese).
19. Kunnumakkara AB, Diagaradjane P, Anand P, et al: Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model. Int J Cancer 125: 2187-2197, 2009.
20. Li J-T: Effect of astragalus polysaccharides on bleomycin-induced pulmonary fibrosis rats. China Journal of Traditional Chinese Medicine and Pharmacy 10: 2360-2363, 2011 (In Chinese).
21. Hou Y: Progress in association between antenatal infection, inflammation and broncho pulmonary dysplasia of newborn. International Journal of Padiatrics 36: 143-146, 2009 (In Chinese).
22. Lee JW and Davis JM: Future applications of antioxidants in premature infants. Curr Opin Pediatr 23: 161-166, 2011.
23. Welty SE: Is there a role for antioxidant therapy in bronchopulmonary dysplasia? J Nutr 131: 947S-950S, 2001.
24. Martindale JL and Holbrook NJ: Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol 192: 1-15, 2002.
25. Chen R, Shao H, Lin S, Zhang JJ and Xu KQ: Treatment with Astragalus membranaceus produces antioxidative effects and attenuates intestinal mucosa injury induced by intestinal ischemia-reperfusion in rats. Am J Chin Med 39: 879-887, 2011.
26. Xiping Z, Ke W, Yaping Y, Hongchan Z and Qihui C: Protective effect and mechanisms of radix astragali injection on the intestinal mucosa of rats with obstructive jaundice. Mediators Inflamm 2010: 757191, 2010.
27. Li XT, Zhang YK, Kuang HX, et al: Mitochondrial protection and anti-aging activity of astragalus polysaccharides and their potential mechanism. Int J Mol Sci 13: 1747-1761, 2012.
28. Li X, He DL, Cheng XF, Zhang LL, Yu LH and Li JJ: Effects of components isolated from Astragalus mongholicus on expression of p-selectin in shock wave induced kidney injury in rabbit model. Zhongguo Zhong Yao Za Zhi 30: 1606-1609, 2005 (In Chinese).
29. Hall G, Hasday JD and Rogers TB: Regulating the regulator: NF-kappaB signaling in heart. J Mol Cell Cardiol 41: 580-591, 2006.
30. Zhong C, Zhou Y and Liu H: Nuclear factor kappaB and anesthetic preconditioning during myocardial ischemia-reperfusion. Anesthesiology 100: 540-546, 2004.
31. Van Zee KJ, Fischer E, Hawes AS, et al: Effects of intravenous IL-8 administration in nonhuman primates. J Immunol 148: 1746-1752, 1992.
32. Wu Y, Zhang R, Zhou C, et al: Enhanced expression of vascular cell adhesion molecule-1 by corticotrophin-releasing hormone contributes to progression of atherosclerosis in LDL receptor-deficient mice. Atherosclerosis 203: 360-370, 2009.
33. Hao Y, Qiu QY and Wu J: Effect of Astragalus polysaccharides in promoting neutrophil-vascular endothelial cell adhesion and expression of related adhesive molecules. Zhongguo Zhong Xi Yi Jie He Za Zhi 24: 427-430, 2004 (In Chinese).
34. Yuan Y, Sun M and Li KS: Astragalus mongholicus polysaccharide inhibits lipopolysaccharide-induced production of TNF-alpha and interleukin-8. World J Gastroenterol 15: 3676-3680, 2009.