Saponin fraction from Astragalus membranaceus roots protects mice against polymicrobial sepsis induced by cecal ligation and puncture by inhibiting inflammation and upregulating protein C pathway

Journal of Natural Medicines

Volumn 63, Issue 4, 2009, Pages 421-429

  Gao, Xing Hua ^a   Xu, Xian Xiang ^a   Pan, Rong ^a   Li, Ying ^a   Luo, Yu Bin ^a   Xia, Yu Feng ^a   Murata, Kazuya ^b   Matsuda, Hideaki ^b   Dai, Yue ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b KINKI UNIVERSITY   (Japan)

Author keywords

Astragalus membranaceus; Endothelial protein C receptor; Protein C; Saponin; Sepsis; Thrombomodulin

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIINFECTIVE AGENT; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LACTATE DEHYDROGENASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; MYELOPEROXIDASE; NITRIC OXIDE; PROTEIN C; SAPONIN; THROMBOMODULIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASTRAGALUS MEMBRANACEUS; CECUM LIGATION; CONTROLLED STUDY; EDEMA; ENDOTHELIUM INJURY; HISTOPATHOLOGY; INFECTION PREVENTION; INFLAMMATION; LIGATION; LIVER DYSFUNCTION; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PLANT ROOT; POLYMICROBIAL SEPSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PUNCTURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEPSIS; SURVIVAL RATE; TISSUE; UPREGULATION;

ANIMALS; ANTIGENS, CD; ASTRAGALUS MEMBRANACEUS; CECUM; CELLS, CULTURED; ENDOTHELIAL CELLS; HUMANS; LIPOPOLYSACCHARIDES; MICE; PLANT EXTRACTS; PLANT ROOTS; PROTEIN C; PUNCTURES; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SAPONINS; SEPSIS; SIGNAL TRANSDUCTION; THROMBOMODULIN;

EID: 69949138137     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-009-0348-2     Document Type: Article

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