In vitro antiinflammatory activity of a new sesquiterpene lactone isolated from Siegesbeckia glabrescens

Phytotherapy Research

Volumn 25, Issue 9, 2011, Pages 1323-1327

  Li, Hua ^a   Kim, Jae Yeon ^a   Hyeon, Jinseong ^a   Lee, Hwa Jin ^a   Ryu, Jae Ha ^a  

^a Sookmyung Women's University   (South Korea)

Author keywords

inhibitor; nitric oxide; nuclear factor B; prostaglandin E 2; sesquiterpenes; Siegesbeckia glabrescens

Indexed keywords

2 PROPENOIC ACID 2 METHYL 2,3,3A,4,5,8,9,10,11,11A DECAHYDRO 6,10 BIS(HYDROXYMETHYL) 3 METHYLENE 2 OXOCYCLODECA[B]FURAN 4 YL ESTER; CYCLOOXYGENASE 2; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PROSTAGLANDIN E2; SESQUITERPENE LACTONE DERIVATIVE; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; LACTONE; NOS2 PROTEIN, MOUSE; PLANT EXTRACT; PTGS2 PROTEIN, MOUSE; RELA PROTEIN, MOUSE; SESQUITERPENE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL NUCLEUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ISOLATION; GENE EXPRESSION; MACROPHAGE; MEDICINAL PLANT; MOUSE; NONHUMAN; PROSTAGLANDIN SYNTHESIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIEGESBECKIA GLABRESCENS; TRANSCRIPTION REGULATION; ANIMAL; ASTERACEAE; CELL LINE; CHEMISTRY; DRUG EFFECTS; METABOLISM;

SIEGESBECKIA;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ASTERACEAE; CELL LINE; CYCLOOXYGENASE 2; DINOPROSTONE; LACTONES; MACROPHAGES; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PLANT EXTRACTS; SESQUITERPENES; TRANSCRIPTION FACTOR RELA;

EID: 80051843305     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3420     Document Type: Article

References (23)

1. Ahn KS, Noh EJ, Zhao HL, Jung SH, Kang SS, Kim YS,. 2005. Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-kappaB activation in RAW 264.7 cells. Life Sci 76: 2315-2328. (Pubitemid 40313419)
2. China Pharmacopoeia Committee. 2005. Chinese Pharmacopoeia. Chemical Industry Press: Beijing, 255.
3. Chou GX, Jin RM, Wang ZT, Chen CX,. 2006. Study on antithrombotic fraction of Herba Siegesbeckiae. Zhong Yao Cai 29: 235-237.
4. Forstermann U, Schmidt HH, Pollock JS, et al., 1991. Isoforms of nitric oxide synthase. Characterization and purification from different cell types. Biochem Pharmacol 42: 1849-1857.
5. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR,. 1982. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem 126: 131-138. (Pubitemid 13203451)
6. Hinz B, Brune K,. 2002. Cyclooxygenase-2-10years later. J Pharmacol Exp Ther 300: 367-375.
7. Hu HH, Tang LX, Li XM,. 2004. Experimental research of effect of crude and processed Herba Siegesbeckiae on anti-inflammation and anti-rheumatism. Zhongguo Zhong Yao Za Zhi 29: 542-545.
8. Jun SY, Choi YH, Shin HM,. 2006. Siegesbeckia glabrescens induces apoptosis with different pathways in human MCF-7 and MDA-MB-231 breast carcinoma cells. Oncol Rep 15: 1461-1467.
9. Kim HM, Lee JH, Won JH, et al., 2001. Inhibitory effect on immunoglobulin E production in vivo and in vitro by Siegesbeckia glabrescens. Phytother Res 15: 572-576.
10. Kim JY,. 2007. Expression inhibitors of inducible nitric oxide synthase and cyclooxygenase-2 from Siegesbeckia glabrescens. Master Degree Thesis. Sookmyung Women's University: Seoul, Korea.
11. Kim JY, Lim HJ, Ryu JH,. 2008. In vitro anti-inflammatory activity of 3-O-methyl-flavones isolated from Siegesbeckia glabrescens. Bioorg Med Chem Lett 18: 1511-1514. (Pubitemid 351226516)
12. Kim S, Na M, Oh H, et al., 2006. PTP1B inhibitory activity of kaurane diterpenes isolated from Siegesbeckia glabrescens. J Enzyme Inhib Med Chem 21: 379-383. (Pubitemid 44355786)
13. Kinne RW, Brauer R, Stuhlmuller B, Palombo-Kinne E, Burmester GR,. 2000. Macrophages in rheumatoid arthritis. Arthritis Res 2: 189-202. (Pubitemid 32223726)
14. Kubes P, McCafferty DM,. 2000. Nitric oxide and intestinal inflammation. Am J Med 109: 150-158.
15. Lee SH, Soyoola E, Chanmugam P, et al., 1992. Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J Biol Chem 267: 25934-25938. (Pubitemid 23013998)
16. Lin WW, Karin M,. 2007. A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest 117: 1175-1183. (Pubitemid 46718402)
17. Molloy RG, Mannick JA, Rodrick ML,. 1993. Cytokines, sepsis and immunomodulation. Br J Surg 80: 289-297. (Pubitemid 23091517)
18. Moncada S, Palmer RM, Higgs EA,. 1991. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43: 109-142.
19. Moon KY, Hahn BS, Lee J, Kim YS,. 2001. A cell-based assay system for monitoring NF-kappaB activity in human HaCat transfectant cells. Anal Biochem 292: 17-21. (Pubitemid 32417717)
20. Peri KG, Hardy P, Li DY, Varma DR, Chemtob S,. 1995. Prostaglandin G/H synthase-2 is a major contributor of brain prostaglandins in the newborn. J Biol Chem 270: 24615-24620.
21. Qian R, Zhang C, Fu H,. 2000. Study on therapeutic mechanism of anti-rheumatism action of herba siegesbeckiae. Zhongguo Zhong Xi Yi Jie He Za Zhi 20: 192-195.
22. Surh YJ, Chun KS, Cha HH, et al., 2001. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res 480-481: 243-268.
23. Xiang Y, Fan CQ, Yue JM,. 2005. Novel sesquiterpenoids from Siegesbeckia orientalis. Helv Chim Acta 88: 160-170. (Pubitemid 40312920)