Drugs interacting with organic anion transporter-1 affect uptake of Tc-99m-mercaptoacetyl-triglycine (MAG3) in the human kidney: Therapeutic drug interaction in Tc-99m-MAG3 diagnosis of renal function and possible application of Tc-99m-MAG3 for drug development

Nuclear Medicine and Biology

Volumn 40, Issue 5, 2013, Pages 643-650

  Takahara, Noriko ^a   Saga, Tsuneo ^b   Inubushi, Masayuki ^b   Kusuhara, Hiroyuki ^c   Seki, Chie ^b   Ito, Sumito ^c   Oyama, Nobuyuki ^a   Yokoyama, Osamu ^a   Sugiyama, Yuichi ^d   Fujibayashi, Yasuhisa ^b  

^a UNIVERSITY OF FUKUI   (Japan)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d RIKEN   (Japan)

Author keywords

Drug interaction; Kidney; MAG3; OAT1; Organic anion transporter

Indexed keywords

4 AMINOHIPPURIC ACID; CREATININE; MERTIATIDE TC 99M; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3; PROBENECID;

ADULT; ARTICLE; BINDING AFFINITY; CELL STRAIN HEK293; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG TRANSPORT; DRUG UPTAKE; GLOMERULUS FILTRATION RATE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; KIDNEY CELL; KIDNEY FUNCTION; KIDNEY TUBULE ABSORPTION; MALE; NORMAL HUMAN; PLASMA CLEARANCE; PROTEIN EXPRESSION;

ADULT; BIOLOGICAL TRANSPORT; CROSS-OVER STUDIES; DRUG DISCOVERY; GLOMERULAR FILTRATION RATE; HEALTHY VOLUNTEERS; HUMANS; KIDNEY; KIDNEY FUNCTION TESTS; MALE; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; P-AMINOHIPPURIC ACID; PROBENECID; PROTEIN BINDING; TECHNETIUM TC 99M MERTIATIDE; YOUNG ADULT;

EID: 84878180138     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2013.03.006     Document Type: Article

References (25)

1. Masereeuw R., Russel F.G. Therapeutic implications of renal anionic drug transporters. Pharmacol Ther 2010, 126:200-216.
2. Melis M., de Swart J., de Visser M., Berndsen S.C., Koelewijn S., Valkema R., et al. Dynamic and static small-animal SPECT in rats for monitoring renal function after 177Lu-labeled Tyr3-octreotate radionuclide therapy. J Nucl Med 2010, 51:1962-1968.
3. Fritzberg A.R., Kasina S., Eshima D., Johnson D.L. Synthesis and biological evaluation of technetium-99m MAG3 as a hippuran replacement. J Nucl Med 1986, 27:111-116.
4. Durand E., Chaumet-Riffaud P., Grenier N. Functional renal imaging: new trends in radiology and nuclear medicine. Semin Nucl Med 2011, 41:61-72.
5. Russell C.D., Dubovsky E.V. Reproducibility of single-sample clearance of 99mTc-mercaptoacetyltriglycine and 131I-orthoiodohippurate. J Nucl Med 1999, 40:1122-1124.
6. Hosoyamada M., Sekine T., Kanai Y., Endou H. Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am J Physiol 1999, 276:F122-F128.
7. Burckhardt G. Drug transport by organic anion transporters (OATs). Pharmacol Ther 2012, 136:106-130.
8. Giacomini K.M., Huang S.M., Tweedie D.J., Benet L.Z., Brouwer K.L., Chu X., et al. Membrane transporters in drug development. Nat Rev Drug Discov 2010, 9:215-236.
9. Shikano N., Kanai Y., Kawai K., Ishikawa N., Endou H. Transport of 99mTc-MAG3 via rat renal organic anion transporter 1. J Nucl Med 2004, 45:80-85.
10. Cha S.H., Sekine T., Fukushima J.I., Kanai Y., Kobayashi Y., Goya T., et al. Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol 2001, 59:1277-1286.
11. Nozaki Y., Kusuhara H., Kondo T., Hasegawa M., Shiroyanagi Y., Nakazawa H., et al. Characterization of the uptake of organic anion transporter (OAT) 1 and OAT3 substrates by human kidney slices. J Pharmacol Exp Ther 2007, 321:362-369.
12. Takeda M., Narikawa S., Hosoyamada M., Cha S.H., Sekine T., Endou H. Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters. Eur J Pharmacol 2001, 419:113-120.
13. Mulato A.S., Ho E.S., Cihlar T. Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1. J Pharmacol Exp Ther 2000, 295:10-15.
14. Tahara H., Kusuhara H., Endou H., Koepsell H., Imaoka T., Fuse E., et al. A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther 2005, 315:337-345.
15. Shitara Y., Sato H., Sugiyama Y. Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs. Annu Rev Pharmacol Toxicol 2005, 45:689-723.
16. Inoue Y., Ohtake T., Yokoyama I., Yoshikawa K., Asai S., Ohtomo K. Evaluation of renal function from 99mTc-MAG3 renography without blood sampling. J Nucl Med 1999, 40:793-798.
17. Kusuhara H., Ito S., Kumagai Y., Jiang M., Shiroshita T., Moriyama Y., et al. Effects of a MATE protein inhibitor, pyrimethamine, on the renal elimination of metformin at oral microdose and at therapeutic dose in healthy subjects. Clin Pharmacol Ther 2011, 89:837-844.
18. Irie F., Iso H., Sairenchi T., Fukasawa N., Yamagishi K., Ikehara S., et al. The relationships of proteinuria, serum creatinine, glomerular filtration rate with cardiovascular disease mortality in Japanese general population. Kidney Int 2006, 69:1264-1271.
19. Du Bois D., Du Bois E.F. A formula to estimate the approximate surface area if height and weight be known. 1916. Nutrition 1989, 5:303-311. [discussion 12-3].
20. Deguchi T., Kusuhara H., Takadate A., Endou H., Otagiri M., Sugiyama Y. Characterization of uremic toxin transport by organic anion transporters in the kidney. Kidney Int 2004, 65:162-174.
21. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J Biol Chem 1951, 193:265-275.
22. Yamaoka K., Tanigawara Y., Nakagawa T., Uno T. A pharmacokinetic analysis program (multi) for microcomputer. J Pharmacobiodyn 1981, 4:879-885.
23. Gilman AG, Rall TW, Nies AS, Taylor P, editors. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York: Pergamon Press, 1990.
24. Itoh K. 99mTc-MAG3: review of pharmacokinetics, clinical application to renal diseases and quantification of renal function. Ann Nucl Med 2001, 15:179-190.
25. Hasegawa M., Kusuhara H., Endou H., Sugiyama Y. Contribution of organic anion transporters to the renal uptake of anionic compounds and nucleoside derivatives in rat. J Pharmacol Exp Ther 2003, 305:1087-1097.