The Val158Met polymorphism of the COMT gene is associated with increased pain sensitivity in morphine-treated patients undergoing a painful procedure after cardiac surgery

British Journal of Clinical Pharmacology

Volumn 75, Issue 6, 2013, Pages 1506-1515

  Ahlers, Sabine J G M ^a,b   Elens, Laure L ^c   van Gulik, Laura ^a   van Schaik, Ron H ^c   van Dongen, Eric P A ^a   Bruins, Peter ^a   Tibboel, Dick ^b   Knibbe, Catherijne A J ^a,b,d  

^a ST ANTONIUS HOSPITAL   (Netherlands)

^b SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Cardiac surgery; COMTVal158Met polymorphism; Genetics; Intensive care patients; Numerical rating scale; Pain sensitivity

Indexed keywords

CATECHOL METHYLTRANSFERASE; METHIONINE; MORPHINE; VALINE;

ADULT; AGED; ALLELE; ARTICLE; CARDIAC PATIENT; CONTROLLED STUDY; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HEART SURGERY; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; NOCICEPTION; OBSERVATIONAL STUDY; PAIN; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SCORING SYSTEM;

AGED; AGED, 80 AND OVER; ANALGESICS, OPIOID; CARDIAC SURGICAL PROCEDURES; CATECHOL O-METHYLTRANSFERASE; FEMALE; HUMANS; MALE; MIDDLE AGED; MORPHINE; NETHERLANDS; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTOPERATIVE PERIOD; PROSPECTIVE STUDIES;

EID: 84878162934     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/bcp.12052     Document Type: Article

References (33)

1. Gelinas C. Management of pain in cardiac surgery ICU patients: have we improved over time? Intensive Crit Care Nurs 2007; 23: 298-303.
2. Allegri M, De Gregori M, Niebel T, Minella C, Tinelli C, Govoni S, Regazzi M, Braschi A. Pharmacogenetics and postoperative pain: a new approach to improve acute pain management. Minerva Anestesiol 2010; 76: 937-944.
3. Puntillo KA, White C, Morris AB, Perdue ST, Stanik-Hutt J, Thompson CL, Wild LR. Patients' perceptions and responses to procedural pain: results from Thunder Project II. Am J Crit Care 2001; 10: 238-251.
4. Siffleet J, Young J, Nikoletti S, Shaw T. Patients' self-report of procedural pain in the intensive care unit. J Clin Nurs 2007; 16: 2142-2148.
5. Ip HY, Abrishami A, Peng PW, Wong J, Chung F. Predictors of postoperative pain and analgesic consumption: a qualitative systematic review. Anesthesiology 2009; 111: 657-677.
6. Rudin A, Wolner-Hanssen P, Hellbom M, Werner MU. Prediction of post-operative pain after a laparoscopic tubal ligation procedure. Acta Anaesthesiol Scand 2008; 52: 938-945.
7. Sommer M, de Rijke JM, van Kleef M, Kessels AG, Peters ML, Geurts JW, Patijn J, Gramke HF, Marcus MA. Predictors of acute postoperative pain after elective surgery. Clin J Pain 2010; 26: 87-94.
8. Young EE, Lariviere WR, Belfer I. Genetic basis of pain variability: recent advances. J Med Genet 2012; 49: 1-9.
9. Rakvåg TT, Klepstad P, Baar C, Kvam TM, Dale O, Kaasa S, Krokan HE, Skorpen F. The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients. Pain 2005; 116: 73-78.
10. Diatchenko L, Slade GD, Nackley AG, Bhalang K, Sigurdsson A, Belfer I, Goldman D, Xu K, Shabalina SA, Shagin D, Max MB, Makarov SS, Maixner W. Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet 2005; 14: 135-143.
11. DeMille MM, Kidd JR, Ruggeri V, Palmatier MA, Goldman D, Odunsi A, Okonofua F, Grigorenko E, Schulz LO, Bonne-Tamir B, Lu RB, Parnas J, Pakstis AJ, Kidd KK. Population variation in linkage disequilibrium across the COMT gene considering promoter region and coding region variation. Hum Genet 2002; 111: 521-537.
12. Xie T, Ho SL, Ramsden D. Characterization and implications of estrogenic down-regulation of human catechol-O-methyltransferase gene transcription. Mol Pharmacol 1999; 56: 31-38.
13. Shifman S, Bronstein M, Sternfeld M, Pisante-Shalom A, Lev-Lehman E, Weizman A, Reznik I, Spivak B, Grisaru N, Karp L, Schiffer R, Kotler M, Strous RD, Swartz-Vanetik M, Knobler HY, Shinar E, Beckmann JS, Yakir B, Risch N, Zak NB, Darvasi A. A highly significant association between a COMT haplotype and schizophrenia. Am J Hum Genet 2002; 71: 1296-1302.
14. Stamer UM, Stuber F. Genetic factors in pain and its treatment. Curr Opin Anaesthesiol 2007; 20: 478-484.
15. Zubieta JK, Heitzeg MM, Smith YR, Bueller JA, Xu K, Xu Y, Koeppe RA, Stohler CS, Goldman D. COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science 2003; 299: 1240-1243.
16. Diatchenko L, Nackley AG, Slade GD, Bhalang K, Belfer I, Max MB, Goldman D, Maixner W. Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain 2006; 125: 216-224.
17. Jensen KB, Lonsdorf TB, Schalling M, Kosek E, Ingvar M. Increased sensitivity to thermal pain following a single opiate dose is influenced by the COMT val(158)met polymorphism. PLoS ONE 2009; 4: e6016.
18. Ahlers SJ, van Gulik L, van Dongen HP, Bruins P, van de Garde EMW, Van Boven WJ, Tibboel D, Knibbe CA. Efficacy of an intravenous bolus of morphine 2.5 versus morphine 7.5 mg for procedural pain relief in postoperative cardiothoracic patients in the intensive care unit: a randomized double-blind controlled trial. Anaesth Intensive Care 2012; 40: 417-426.
19. Hamill-Ruth RJ, Marohn ML. Evaluation of pain in the critically ill patient. Crit Care Clin 1999; 15: 35-54.
20. Jacobi J, Fraser GL, Coursin DB, Riker RR, Fontaine D, Wittbrodt ET, Chalfin DB, Masica MF, Bjerke HS, Coplin WM, Crippen DW, Fuchs BD, Kelleher RM, Marik PE, Nasraway SA Jr, Murray MJ, Peruzzi WT, Lumb PD. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med 2002; 30: 119-141.
21. Jensen MP, Karoly P, Braver S. The measurement of clinical pain intensity: a comparison of six methods. Pain 1986; 27: 117-126.
22. Kremer E, Atkinson JH, Ignelzi RJ. Measurement of pain: patient preference does not confound pain measurement. Pain 1981; 10: 241-248.
23. Todd KH, Funk KG, Funk JP, Bonacci R. Clinical significance of reported changes in pain severity. Ann Emerg Med 1996; 27: 485-489.
24. Ahlers SJ, van Gulik L, van der Veen AM, van Dongen HP, Bruins P, Belitser SV, de Boer A, Tibboel D, Knibbe CA. Comparison of different pain scoring systems in critically ill patients in a general ICU. Crit Care 2008; 12: R15.
25. van Gulik L, Ahlers SJ, Brkic Z, Belitser SV, van Boven WJ, van Dongen EP, Knibbe CA, Bruins P. Improved analgesia after the realisation of a pain management programme in ICU patients after cardiac surgery. Eur J Anaesthesiol 2010; 27: 900-905.
26. Craft RM, Mogil JS, Aloisi AM. Sex differences in pain and analgesia: the role of gonadal hormones. Eur J Pain 2004; 8: 397-411.
27. Fillingim RB, Hastie BA, Ness TJ, Glover TL, Campbell CM, Staud R. Sex-related psychological predictors of baseline pain perception and analgesic responses to pentazocine. Biol Psychol 2005; 69: 97-112.
28. Boudikova B, Szumlanski C, Maidak B, Weinshilboum R. Human liver catechol-O-methyltransferase pharmacogenetics. Clin Pharmacol Ther 1990; 48: 381-389.
29. Loggia ML, Jensen K, Gollub RL, Wasan AD, Edwards RR, Kong J. The Catechol-O-Methyltransferase (COMT) valmet Polymorphism Affects Brain Responses to Repeated Painful Stimuli. PLoS ONE 2011; 6: e27764.
30. Mogil JS. Pain genetics: past, present and future. Trends Genet 2012; 28: 258-266.
31. Kim H, Lee H, Rowan J, Brahim J, Dionne RA. Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans. Mol Pain 2006; 2: 1-10.
32. Klepstad P, Fladvad T, Skorpen F, Bjordal K, Caraceni A, Dale O, Davies A, Kloke M, Lundstrom S, Maltoni M, Radbruch L, Sabatowski R, Sigurdardottir V, Strasser F, Fayers PM, Kaasa S. Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients. Pain 2011; 152: 1139-1145.
33. Kim H, Neubert JK, San Miguel A, Xu K, Krishnaraju RK, Iadarola MJ, Goldman D, Dionne RA. Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament. Pain 2004; 109: 488-496.