Association of plasma neutrophil gelatinase-associated lipocalin (NGAL) with sepsis and acute kidney dysfunction

Biomarkers

Volumn 18, Issue 4, 2013, Pages 349-356

  Mårtensson, Johan ^a   Bell, Max ^a   Xu, Shengyuan ^b   Bottai, Matteo ^c   Ravn, Bo ^a   Venge, Per ^b   Martling, Claes Roland ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Acute kidney injury; Biomarkers; Critical care; CRP; Inflammation; PCT

Indexed keywords

C REACTIVE PROTEIN; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; PROCALCITONIN;

ACUTE KIDNEY DYSFUNCTION; ADULT; ARTICLE; BACTERIAL INFECTION; CRITICALLY ILL PATIENT; DISEASE ASSOCIATION; FEMALE; HUMAN; KIDNEY DISEASE; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; SENSITIVITY AND SPECIFICITY; SEPSIS;

ACUTE DISEASE; ACUTE-PHASE PROTEINS; ADULT; AGED; BIOLOGICAL MARKERS; FEMALE; HUMANS; KIDNEY DISEASES; LIPOCALINS; MALE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS; SENSITIVITY AND SPECIFICITY; SEPSIS;

EID: 84878116334     PISSN: 1354750X     EISSN: 13665804     Source Type: Journal    
DOI: 10.3109/1354750X.2013.787460     Document Type: Article

References (36)

1. Axelsson L, Bergenfeldt M, Ohlsson K. (1995). Studies of the release and turnover of a human neutrophil lipocalin. Scand J Clin Lab Invest 55:577-88
2. Bagshaw SM, Bennett M, Haase M, et al. (2010). Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus nonseptic acute kidney injury in critical illness. Intensive Care Med 36: 452-61
3. Bagshaw SM, Uchino S, Bellomo R, et al. (2007). Septic acute kidney injury in critically ill patients: Clinical characteristics and outcomes. Clin J Am Soc Nephrol 2:431-9
4. Bernard GR, Vincent JL, Laterre PF, et al. (2001). Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 344:699-709 (Pubitemid 32204987)
5. Bone RC, Balk RA, Cerra FB, et al. (1992). Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101:1644-55
6. Borregaard N, Cowland JB. (1997). Granules of the human neutrophilic polymorphonuclear leukocyte. Blood 89:3503-21 (Pubitemid 27227073)
7. Cai L, Borowiec J, Xu S, et al. (2009). Assays of urine levels of HNL/ NGAL in patients undergoing cardiac surgery and the impact of antibody configuration on their clinical performances. Clin Chim Acta 403:121-5
8. Cai L, Rubin J, Han W, et al. (2010). The origin of multiple molecular forms in urine of HNL/NGAL. Clin J Am Soc Nephrol 5:2229-35
9. Calandra T, Cohen J. (2005). The international sepsis forum consensus conference on definitions of infection in the intensive care unit. Crit Care Med 33:1538-48 (Pubitemid 40980610)
10. Constantin JM, Futier E, Perbet S, et al. (2010). Plasma neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in adult critically ill patients: A prospective study. J Crit Care 25:176 e1-6
11. Cruz DN, de Cal M, Garzotto F, et al. (2010). Plasma neutrophil gelatinase-associated lipocalin is an early biomarker for acute kidney injury in an adult ICU population. Intensive Care Med 36: 444-51
12. de Geus HR, Bakker J, Lesaffre EM, le Noble JL. (2011). Neutrophil gelatinase-associated lipocalin at ICU admission predicts for acute kidney injury in adult patients. Am J Respir Crit Care Med 183: 907-14
13. Fjaertoft G, Foucard T, Xu S, Venge P. (2005). Human neutrophil lipocalin (HNL) as a diagnostic tool in children with acute infections: A study of the kinetics. Acta Paediatr 94:661-6 (Pubitemid 40839791)
14. Flo TH, Smith KD, Sato S, et al. (2004). Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 432:917-21 (Pubitemid 40037155)
15. Grigoryev DN, Liu M, Hassoun HT, et al. (2008). The local and systemic inflammatory transcriptome after acute kidney injury. J Am Soc Nephrol 19:547-58 (Pubitemid 351355398)
16. Kjeldsen L, Johnsen AH, Sengelov H, Borregaard N. (1993). Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem 268:10425-32 (Pubitemid 23150227)
17. Klausen P, Niemann CU, Cowland JB, et al. (2005). On mouse and man: Neutrophil gelatinase associated lipocalin is not involved in apoptosis or acute response. Eur J Haematol 75:332-40 (Pubitemid 41297610)
18. Kumpers P, Hafer C, Lukasz A, et al. (2010). Serum neutrophil gelatinase-associated lipocalin at inception of renal replacement therapy predicts survival in critically ill patients with acute kidney injury. Crit Care 14:R9. doi:10.1186/cc8861
19. Kuwabara T, Mori K, Mukoyama M, et al. (2009). Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons. Kidney Int 75:285-94
20. Linscheid P, Seboek D, Nylen ES, et al. (2003). In vitro and in vivo calcitonin I gene expression in parenchymal cells: A novel product of human adipose tissue. Endocrinology 144:5578-84 (Pubitemid 37476087)
21. Linscheid P, Seboek D, Schaer DJ, et al. (2004). Expression and secretion of procalcitonin and calcitonin gene-related peptide by adherent monocytes and by macrophage-activated adipocytes. Crit Care Med 32:1715-21 (Pubitemid 39050523)
22. Martensson J, Bell M, Oldner A, et al. (2010). Neutrophil gelatinaseassociated lipocalin in adult septic patients with and without acute kidney injury. Intensive Care Med 36:1333-40
23. Martensson J, Xu S, Bell M, et al. (2012). Immunoassays distinguishing between HNL/NGAL released in urine from kidney epithelial cells and neutrophils. Clin Chim Acta 413:1661-7
24. Meisner M, Lohs T, Huettemann E, et al. (2001). The plasma elimination rate and urinary secretion of procalcitonin in patients with normal and impaired renal function. Eur J Anaesthesiol 18:79-87 (Pubitemid 32158262)
25. Meisner M, Schmidt J, Huttner H, Tschaikowsky K. (2000). The natural elimination rate of procalcitonin in patients with normal and impaired renal function. Intensive Care Med 26:S212-16 (Pubitemid 30186585)
26. Mishra J, Dent C, Tarabishi R, et al. (2005). Neutrophil gelatinaseassociated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 365:1231-8 (Pubitemid 40469655)
27. Perry TE, Muehlschlegel JD, Liu KY, et al. (2010). Plasma neutrophil gelatinase-associated lipocalin and acute postoperative kidney injury in adult cardiac surgical patients. Anesth Analg 110: 1541-7
28. Prabhu A, Sujatha DI, Ninan B, Vijayalakshmi MA. (2010). Neutrophil gelatinase associated lipocalin as a biomarker for acute kidney injury in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass. Ann Vasc Surg 24:525-31
29. Schmidt-Ott KM, Mori K, Li JY, Kalandadze A, et al. (2007). Dual action of neutrophil gelatinase-associated lipocalin. J Am Soc Nephrol 18:407-13 (Pubitemid 46193306)
30. Tang BM, Eslick GD, Craig JC, McLean AS. (2007). Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: Systematic review and meta-analysis. Lancet Infect Dis 7:210-17 (Pubitemid 46274517)
31. Uchino S, Kellum JA, Bellomo R, Doig GS, et al. (2005). Acute renal failure in critically ill patients: A multinational, multicenter study. JAMA 294:813-18 (Pubitemid 41175724)
32. Uzzan B, Cohen R, Nicolas P, et al. (2006). Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: A systematic review and meta-analysis. Crit Care Med 34:1996-2003 (Pubitemid 43982479)
33. Vincent JL, Sakr Y, Sprung CL, et al. (2006). Sepsis in European intensive care units: Results of the SOAP study. Crit Care Med 34: 344-53 (Pubitemid 43145611)
34. Xu SY, Pauksen K, Venge P. (1995). Serum measurements of human neutrophil lipocalin (HNL) discriminate between acute bacterial and viral infections. Scand J Clin Lab Invest 55:125-31
35. Xu SY, Carlson M, Engstrom A, et al. (1994a). Purification and characterization of a human neutrophil lipocalin (HNL) from the secondary granules of human neutrophils. Scand J Clin Lab Invest 54: 365-76 (Pubitemid 24246789)
36. Xu SY, Petersson CG, Carlson M, Venge P. (1994b). The development of an assay for human neutrophil lipocalin (HNL)-to be used as a specific marker of neutrophil activity in vivo and vitro. J Immunol Methods 171:245-52. (Pubitemid 24161435)