Neutrophil gelatinase-associated lipocalin in adult septic patients with and without acute kidney injury

Intensive Care Medicine

Volumn 36, Issue 8, 2010, Pages 1333-1340

  Mårtensson, Johan ^a   Bell, Max ^a   Oldner, Anders ^a   Xu, Shengyuan ^b   Venge, Per ^b   Martling, Claes Roland ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

AKI; Cystatin C; HNL; NGAL; RIFLE; Sepsis

Indexed keywords

ALPHA 1 MICROGLOBULIN; C REACTIVE PROTEIN; CREATININE; CYSTATIN C; MYELOPEROXIDASE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; PROCALCITONIN; ACUTE PHASE PROTEIN; BIOLOGICAL MARKER; LCN2 PROTEIN, HUMAN; LIPOCALIN; ONCOPROTEIN;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; FEMALE; HUMAN; INTENSIVE CARE UNIT; KIDNEY INJURY; MAJOR CLINICAL STUDY; MALE; PATIENT ASSESSMENT; RECEIVER OPERATING CHARACTERISTIC; SEPSIS; SEPTIC SHOCK; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; ACUTE KIDNEY INJURY; BLOOD; CRITICAL ILLNESS; EARLY DIAGNOSIS; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PREDICTIVE VALUE; SENSITIVITY AND SPECIFICITY; URINE;

ACUTE-PHASE PROTEINS; ADULT; BIOLOGICAL MARKERS; CRITICAL ILLNESS; EARLY DIAGNOSIS; FEMALE; HUMANS; KIDNEY FAILURE, ACUTE; LIPOCALINS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROTO-ONCOGENE PROTEINS; SENSITIVITY AND SPECIFICITY; SEPSIS; ACUTE KIDNEY INJURY;

EID: 77956171921     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-010-1887-4     Document Type: Article

References (34)

1. Mishra J, Dent C, Tarabishi R,Mitsnefes MM, Ma Q, Kelly C, RuffSM, Zahedi K, Shao M, Bean J, Mori K,Barasch J, Devarajan P (2005)Neutrophil gelatinase-associatedlipocalin (NGAL) as a biomarker foracute renal injury after cardiac surgery.Lancet 365:1231-1238
2. Wagener G, Jan M, Kim M, Mori K,Barasch JM, Sladen RN, Lee HT (2006)Association between increases inurinary neutrophil gelatinase- associatedlipocalin and acute renal dysfunctionafter adult cardiac surgery.Anesthesiology 105:485-491
3. Hirsch R, Dent C, Pfriem H, Allen J,Beekman RH 3rd, Ma Q, Dastrala S,Bennett M, Mitsnefes M, Devarajan P(2007) NGAL is an early predictivebiomarker of contrast-inducednephropathy in children. PediatrNephrol 22:2089-2095
4. Bachorzewska-Gajewska H, MalyszkoJ, Sitniewska E, Malyszko JS, PawlakK, Mysliwiec M, Lawnicki S,Szmitkowski M, Dobrzycki S (2007)Could neutrophil-gelatinase-associatedlipocalin and cystatin C predict thedevelopment of contrast-inducednephropathy after percutaneouscoronary interventions in patients withstable angina and normal serumcreatinine values? Kidney Blood PressRes 30:408-415
5. Xu SY, Pauksen K, Venge P (1995)Serum measurements of humanneutrophil lipocalin (HNL) discriminatebetween acute bacterial and viralinfections. Scand J Clin Lab Invest 55:125-131
6. Fjaertoft G, Foucard T, Xu S, Venge P(2005) Human neutrophil lipocalin(HNL) as a diagnostic tool in childrenwith acute infections: a study of thekinetics. Acta Paediatr 94:661-666
7. Mori K, Lee HT, Rapoport D, Drexler IR, Foster K, Yang J, Schmidt-Ott KM,Chen X, Li JY, Weiss S, Mishra J,Cheema FH, Markowitz G, Suganami T, Sawai K, Mukoyama M, Kunis C,D'Agati V, Devarajan P, Barasch J(2005) Endocytic delivery of lipocalinsiderophore-iron complex rescues thekidney from ischemia- reperfusioninjury. J Clin Invest 115:610-621
8. Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E,Gibney N, Tolwani A, Ronco C (2005)Acute renal failure in critically illpatients: a multinational, multicenterstudy. JAMA 294:813-818
9. Bagshaw SM, Uchino S, Bellomo R,Morimatsu H, Morgera S, Schetz M,Tan I, Bouman C, Macedo E, Gibney N,Tolwani A, Oudemans-van Straaten HM, Ronco C, Kellum JA (2007) Septicacute kidney injury in critically illpatients: clinical characteristics andoutcomes. Clin J Am Soc Nephrol 2:431-439
10. Cruz DN, de Cal M, Garzotto F,Perazella MA, Lentini P, Corradi V,Piccinni P, Ronco C (2010) Plasmaneutrophil gelatinase-associatedlipocalin is an early biomarker for acutekidney injury in an adult ICUpopulation. Intensive Care Med 36:444-451
11. Wheeler DS, Devarajan P, Ma Q,Harmon K, Monaco M, Cvijanovich N,Wong HR (2008) Serum neutrophilgelatinase-associated lipocalin (NGAL)as a marker of acute kidney injury incritically ill children with septic shock.Crit Care Med 36:1297-1303
12. Zappitelli M, Washburn KK, Arikan AA, Loftis L, Ma Q, Devarajan P,Parikh CR, Goldstein SL (2007) Urineneutrophil gelatinase-associatedlipocalin is an early marker of acutekidney injury in critically ill children: A prospective cohort study. Crit Care11:R84
13. Bagshaw SM, Bennett M, Haase M,Haase-Fielitz A, Egi M, Morimatsu H,D'Amico G, Goldsmith D, Devarajan P,Bellomo R (2010) Plasma and urineneutrophil gelatinase-associatedlipocalin in septic versus non-septicacute kidney injury in critical illness.Intensive Care Med 36:452-461
14. Bellomo R, Ronco C, Kellum JA,Mehta RL, Palevsky P (2004) Acuterenal failure: definition, outcomemeasures, animal models, fluid therapyand information technology needs: thesecond international consensusconference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 8:R204-R212
15. Mehta RL, Kellum JA, Shah SV,Molitoris BA, Ronco C, Warnock DG,Levin A (2007) Acute kidney injurynetwork: report of an initiative toimprove outcomes in acute kidneyinjury. Crit Care 11:R31
16. Kellum JA, Bellomo R, Ronco C (2008)Definition and classification of acutekidney injury. Nephron Clin Pract109:c182-c187
17. Bone RC, Balk RA, Cerra FB,Dellinger RP, Fein AM, Knaus WA,Schein RM, Sibbald WJ (1992)Definitions for sepsis and organ failureand guidelines for the use of innovativetherapies in sepsis The ACCP/SCCMconsensus conference committee.American College of Chest Physicians/Society of Critical Care Medicine.Chest 101:1644-1655
18. Bernard GR, Vincent JL, Laterre PF,La Rosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE,Helterbrand JD, Ely EW, Fisher CJ Jr(2001) Efficacy and safety ofrecombinant human activated protein Cfor severe sepsis. N Engl J Med 344:699-709
19. Xu SY, Petersson CG, Carlson M,Venge P (1994) The development of anassay for human neutrophil lipocalin(HNL)\to be used as a specific markerof neutrophil activity in vivo and vitro.J Immunol Methods 171:245-252
20. Cai L, Borowiec J, Xu S, Han W,Venge P (2009) Assays of urine levelsof HNL/NGAL in patients undergoingcardiac surgery and the impact ofantibody configuration on their clinicalperformances. Clin Chim Acta 403:121-125
21. Nickolas TL, O'Rourke MJ, Yang J,Sise ME, Canetta PA, Barasch N,Buchen C, Khan F, Mori K, Giglio J,Devarajan P, Barasch J (2008)Sensitivity and specificity of a singleemergency department measurement ofurinary neutrophil gelatinase-associatedlipocalin for diagnosing acute kidneyinjury. Ann Intern Med 148:810-819
22. Makris K, Markou N, Evodia E,Dimopoulou E, Drakopoulos I, Ntetsika K, Rizos D, Baltopoulos G, Haliassos A(2009) Urinary neutrophil gelatinaseassociatedlipocalin (NGAL) as an earlymarker of acute kidney injury incritically ill multiple trauma patients.Clin Chem Lab Med 47:79-82
23. Xu SY, Carlson M, Engstrom A, Garcia R, Peterson CG, Venge P (1994)Purification and characterization of ahuman neutrophil lipocalin (HNL) fromthe secondary granules of humanneutrophils. Scand J Clin Lab Invest 54:365-376
24. Brunkhorst FM, Wegscheider K,Forycki ZF, Brunkhorst R (2000)Procalcitonin for early diagnosis anddifferentiation of SIRS, sepsis, severesepsis, and septic shock. Intensive Care Med 26(Suppl 2):S148-S152
25. Luzzani A, Polati E, Dorizzi R,Rungatscher A, Pavan R, Merlini A(2003) Comparison of procalcitonin and C-reactive protein as markers of sepsis.Crit Care Med 31:1737-1741
26. Dent CL, Ma Q, Dastrala S, Bennett M,Mitsnefes MM, Barasch J, Devarajan P(2007) Plasma neutrophil gelatinaseassociatedlipocalin predicts acutekidney injury, morbidity and mortalityafter pediatric cardiac surgery: aprospective uncontrolled cohort study.Crit Care 11:R127
27. Tuladhar SM, Puntmann VO, Soni M,Punjabi PP, Bogle RG (2009) Rapiddetection of acute kidney injury byplasma and urinary neutrophilgelatinase- associated lipocalin aftercardiopulmonary bypass. J Cardiovasc Pharmacol 53:261-266
28. Bell M, Granath F, Martensson J,Lofberg E, Ekbom A, Martling CR(2009) Cystatin C is correlated withmortality in patients with and withoutacute kidney injury. Nephrol Dial Transplant 24:3096-3102
29. Risch L, Herklotz R, Blumberg A,Huber AR (2001) Effects ofglucocorticoid immunosuppression onserum cystatin C concentrations in renaltransplant patients. Clin Chem 47:2055-2059
30. Poge U, Gerhardt T, Bokenkamp A,Stoffel-Wagner B, Klehr HU,Sauerbruch T, Woitas RP (2004) Timecourse of low molecular weight proteinsin the early kidney transplantationperiod\influence of corticosteroids.Nephrol Dial Transplant 19:2858-2863
31. Bokenkamp A, Laarman CA, Braam KI, Van Wijk JA, Kors WA, Kool M, de Valk J, Bouman AA, Spreeuwenberg MD, Stoffel-Wagner B (2007) Effect ofcorticosteroid therapy on low-molecularweight protein markers of kidneyfunction. Clin Chem 53:2219-2221
32. Strevens H, Wide-Swensson D, Grubb A, Hansen A, Horn T, Ingemarsson I,Larsen S, Nyengaard JR, Torffvit O,Willner J, Olsen S (2003) Serumcystatin C reflects glomerularendotheliosis in normal, hypertensiveand pre-eclamptic pregnancies. BJOG 110:825-830
33. Joannidis M, Metnitz B, Bauer P,Schusterschitz N, Moreno R, Druml W,Metnitz PG (2009) Acute kidney injuryin critically ill patients classified by AKIN versus RIFLE using the SAPS 3database. Intensive Care Med 35:1692-1702
34. Axelsson L, Bergenfeldt M, Ohlsson K(1995) Studies of the release andturnover of a human neutrophillipocalin. Scand J Clin Lab Invest 55:577-588