Discovery of pyrido[2,3-d]pyrimidine-based inhibitors of HCV NS5A

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 12, 2013, Pages 3627-3630

  Degoey, David A ^a   Betebenner, David A ^a,b   Grampovnik, David J ^a   Liu, Dachun ^a   Pratt, John K ^a   Tufano, Michael D ^a,c   He, Wenping ^a,d   Krishnan, Preethi ^a   Pilot Matias, Tami J ^a   Marsh, Kennan C ^a   Molla, Akhteruzzaman ^a   Kempf, Dale J ^a   Maring, Clarence J ^a  

^a ABBVIE INC   (United States)

^b Infinity Healthcare Advocate Condell Medical Center   (United States)

^c NORTHEASTERN ILLINOIS UNIVERSITY   (United States)

^d JANSSEN RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Antiviral; HCV; Hepatitis C; NS5A

Indexed keywords

AMIDE; NONSTRUCTURAL PROTEIN 5A; NONSTRUCTURAL PROTEIN 5A INHIBITOR; PROTEIN INHIBITOR; PYRIDO[2,3 D]PYRIMIDINE BASED INHIBITOR; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHIMPANZEE; CHIRALITY; CONTROLLED STUDY; DRUG DETERMINATION; DRUG POTENCY; DRUG SOLUBILITY; GENE MUTATION; GENOTYPE; HEPATITIS C; IN VIVO STUDY; NONHUMAN; REPLICON; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; VIRUS LOAD; VIRUS REPLICATION;

DRUG DISCOVERY; HUMANS; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS; PAN;

EID: 84878112147     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.04.009     Document Type: Article

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