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Volumn 381, Issue 9880, 2013, Pages 1797-1798

First-in-human trial of Dz13 for nodular basal-cell carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DNAZYME DZ13; LIPOSOME; MESSENGER RNA; NUCLEIC ACID BASE; PROTEIN C JUN; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

EID: 84878110171     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(13)60633-9     Document Type: Note
Times cited : (8)

References (14)
  • 1
    • 77953350228 scopus 로고    scopus 로고
    • Current strategies to improve the efficacy and the delivery of nucleic acid based drugs
    • Grassi M, Cavallaro G, Scirè S, et al. Current strategies to improve the efficacy and the delivery of nucleic acid based drugs. Curr Signal Transduct Ther 2010; 5: 92-120.
    • (2010) Curr Signal Transduct Ther , vol.5 , pp. 92-120
    • Grassi, M.1    Cavallaro, G.2    Scirè, S.3
  • 2
    • 0030898510 scopus 로고    scopus 로고
    • A general purpose RNA-cleaving DNA enzyme
    • Santoro SW, Joyce GF A general purpose RNA-cleaving DNA enzyme. Proc Natl Acad Sci USA 1997; 94: 4262-66.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4262-4266
    • Santoro, S.W.1    Joyce, G.F.2
  • 4
    • 73949158248 scopus 로고    scopus 로고
    • C-jun DNAzymes inhibit myocardial inflammation, ROS generation, infarct size, and improve cardiac function after ischemia-reperfusion injury
    • Luo X, Cai H, Ni J., et al c-Jun DNAzymes inhibit myocardial inflammation, ROS generation, infarct size, and improve cardiac function after ischemia-reperfusion injury. Arterioscler Thromb Vasc Biol 2009; 29: 1836-42.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 1836-1842
    • Luo, X.1    Cai, H.2    Ni, J.3
  • 5
    • 0036792125 scopus 로고    scopus 로고
    • Angiogenic inhibition mediated by a DNAzyme that targets vascular endothelial growth factor receptor 2
    • Zhang L, Gasper WJ, Stass S.A., Ioffe OB, Davis MA, Mixson AJ Angiogenic inhibition mediated by a DNAzyme that targets vascular endothelial growth factor receptor 2. Cancer Res 2002; 62: 5463-69.
    • (2002) Cancer Res , vol.62 , pp. 5463-5469
    • Zhang, L.1    Gasper, W.J.2    Stass, S.A.3    Ioffe, O.B.4    Davis, M.A.5    Mixson, A.J.6
  • 7
    • 33746153397 scopus 로고    scopus 로고
    • Suppression of vascular permeability and inflammation by targeting of the transcription factor c-jun
    • Fahmy RG, Waldman A, Zhang G., et al Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun. Nat Biotechnol 2006; 24: 856-63.
    • (2006) Nat Biotechnol , vol.24 , pp. 856-863
    • Fahmy, R.G.1    Waldman, A.2    Zhang, G.3
  • 8
    • 0041464740 scopus 로고    scopus 로고
    • Transcription factor egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth
    • Fahmy RG, Dass CR, Sun L.Q., Chesterman CN, Khachigian LM Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth. Nat Med 2003; 9: 1026-32.
    • (2003) Nat Med , vol.9 , pp. 1026-1032
    • Fahmy, R.G.1    Dass, C.R.2    Sun, L.Q.3    Chesterman, C.N.4    Khachigian, L.M.5
  • 9
    • 0032717640 scopus 로고    scopus 로고
    • New DNA enzyme targeting egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury
    • Santiago FS, Lowe HC, Kavurma M.M., et al New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury. Nat Med 1999; 5: 1264-69.
    • (1999) Nat Med , vol.5 , pp. 1264-1269
    • Santiago, F.S.1    Lowe, H.C.2    Kavurma, M.M.3
  • 10
    • 84878113156 scopus 로고    scopus 로고
    • Safety and tolerability of an intratumorally injected DNAzyme, dz13, in patients with nodular basal-cell carcinoma: A phase 1 first-in-human trial (DISCOVER)
    • published online May 7. http://dx.doi.org/10.1016/S0140-6736(12)62166-7
    • Cho E-A, Moloney F.J., Cai H., et al Safety and tolerability of an intratumorally injected DNAzyme, Dz13, in patients with nodular basal-cell carcinoma: a phase 1 first-in-human trial (DISCOVER). Lancet 2013; published online May 7. http://dx.doi.org/10.1016/S0140-6736(12)62166-7.
    • (2013) Lancet
    • Cho, E.-A.1    Moloney, F.J.2    Cai, H.3
  • 11
    • 84862841985 scopus 로고    scopus 로고
    • DNAzyme targeting c-jun suppresses skin cancer growth
    • Cai H, Santiago FS, Prado-Lourenco L, et al DNAzyme targeting c-jun suppresses skin cancer growth. Sci Transl Med 2012; 4: 139ra82.
    • (2012) Sci Transl Med , vol.4
    • Cai, H.1    Santiago, F.S.2    Prado-Lourenco, L.3
  • 12
    • 79954718554 scopus 로고    scopus 로고
    • C-jun promotes whereas JunB inhibits epidermal neoplasia
    • Jin JY, Ke H, Hall R.P., Zhang JY c-Jun promotes whereas JunB inhibits epidermal neoplasia. J Invest Dermatol 2011; 131: 1149-58.
    • (2011) J Invest Dermatol , vol.131 , pp. 1149-1158
    • Jin, J.Y.1    Ke, H.2    Hall, R.P.3    Zhang, J.Y.4
  • 14
    • 77956647113 scopus 로고    scopus 로고
    • Targeted nanodelivery of drugs and diagnostics
    • Phillips MA, Gran ML, Peppas NA Targeted nanodelivery of drugs and diagnostics. Nano Today 2010; 5: 143-59.
    • (2010) Nano Today , vol.5 , pp. 143-159
    • Phillips, M.A.1    Gran, M.L.2    Peppas, N.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.