Pyranoflavones: A group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1

Journal of Medicinal Chemistry

Volumn 56, Issue 10, 2013, Pages 4082-4092

  Liu, Jiawang ^a   Taylor, Shannon F ^a   Dupart, Patrick S ^a   Arnold, Corey L ^a   Sridhar, Jayalakshmi ^a   Jiang, Quan ^a   Wang, Yuji ^b   Skripnikova, Elena V ^a   Zhao, Ming ^b   Foroozesh, Maryam ^a  

^a XAVIER UNIVERSITY OF LOUISIANA   (United States)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2' HYDROXYFLAVONE; 2',3' PYRANOFLAVONE; 3' HYDROXYFLAVONE; 3',2' PYRANOFLAVONE; 4',3' PYRANOFLAVONE; 5 HYDROXY 3' PROPARGYLOXYFLAVONE; 5 HYDROXY 3',2' PYRANOFLAVONE; 5 HYDROXY 3',4' PYRANOFLAVONE; 5 HYDROXY 4' PROPARGYLOXYFLAVONE; 5 HYDROXY 7 PROPARGYLOXYFLAVONE; 5 HYDROXY 7,6 PYRANOFLAVONE; 5 HYDROXY 7,8 PYRANOFLAVONE; 5,3' DIHYDROXYFLAVONE; 5,4' DIHYDROXYFLAVONE; 5,6 PYRANOFLAVONE; 6 HYDROXYFLAVONE; 6,5 PYRANOFLAVONE; 7 HYDROXYFLAVONE; 7,8 PYRANOFLAVONE; ALPHA NAPHTHOFLAVONE; CHROMONE DERIVATIVE; CHRYSIN; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 INHIBITOR; FLAVONE DERIVATIVE; OXYGENASE INHIBITOR; PRIMULETIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME INHIBITION; FLUOROMETRY; HUMAN; IC 50; MOLECULAR PROBE; NONHUMAN;

ARYL HYDROCARBON HYDROXYLASES; CATALYTIC DOMAIN; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; DATA INTERPRETATION, STATISTICAL; ENZYME INHIBITORS; FLAVONES; FLUOROMETRY; HUMANS; KINETICS; LIGANDS; MODELS, MOLECULAR; SMALL MOLECULE LIBRARIES; SPECTROMETRY, FLUORESCENCE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84878074432     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm4003654     Document Type: Article

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