Misexpression of Pknox2 in Mouse Limb Bud Mesenchyme Perturbs Zeugopod Development and Deltoid Crest Formation

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Zhou, Wenrong ^a   Zhu, Huang ^a   Zhao, Jianzhi ^a   Li, Hanjun ^a   Wan, Yong ^a   Cao, Jingjing ^a   Zhao, Haixia ^a   Yu, Jian ^a   Zhou, Rujiang ^a   Yao, Yiyun ^a   Zhang, Lingling ^a   Wang, Lifang ^a   He, Lin ^a   Ma, Gang ^a   Yao, Zhengju ^a   Guo, Xizhi ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; SMAD PROTEIN;

ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CELL DIFFERENTIATION; COL2 GENE; CONTROLLED STUDY; DELTOID CREST; EMBRYO; EMBRYO DEVELOPMENT; GENE; GENE EXPRESSION; GENE OVEREXPRESSION; HOX10 GENE; HOX11 GENE; LIMB BUD; LIMB DEFORMITY; LIMB DEVELOPMENT; MESENCHYME; MOUSE; NONHUMAN; PKNOX2 GENE; SIGNAL TRANSDUCTION; SKELETON MALFORMATION; ZEUGOPOD;

ANIMALS; BASE SEQUENCE; CHONDROCYTES; DNA PRIMERS; HOMEODOMAIN PROTEINS; LIMB BUDS; MESODERM; MICE; MICE, TRANSGENIC; OSTEOBLASTS; STEM CELLS; TRANSCRIPTION FACTORS;

EID: 84878051992     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0064237     Document Type: Article

References (36)

1. Cooper KL, Hu JK, ten Berge D, Fernandez-Teran M, Ros MA, et al. (2011) Initiation of proximal-distal patterning in the vertebrate limb by signals and growth. Science 332: 1083-1086.
2. Fromental-Ramain C, Warot X, Lakkaraju S, Favier B, Haack H, et al. (1996) Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning. Development 122: 461-472.
3. Xu B, Wellik DM, (2011) Axial Hox9 activity establishes the posterior field in the developing forelimb. Proc Natl Acad Sci U S A 108: 4888-4891.
4. Boulet AM, Capecchi MR, (2004) Multiple roles of Hoxa11 and Hoxd11 in the formation of the mammalian forelimb zeugopod. Development 131: 299-309.
5. Wellik DM, Capecchi MR, (2003) Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton. Science 301: 363-367.
6. Davis AP, Witte DP, Hsieh-Li HM, Potter SS, Capecchi MR, (1995) Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. Nature 375: 791-795.
7. Fromental-Ramain C, Warot X, Messadecq N, LeMeur M, Dolle P, et al. (1996) Hoxa-13 and Hoxd-13 play a crucial role in the patterning of the limb autopod. Development 122: 2997-3011.
8. Kmita M, Tarchini B, Zakany J, Logan M, Tabin CJ, et al. (2005) Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function. Nature 435: 1113-1116.
9. Capellini TD, Di Giacomo G, Salsi V, Brendolan A, Ferretti E, et al. (2006) Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression. Development 133: 2263-2273.
10. Capellini TD, Zappavigna V, Selleri L, (2011) Pbx homeodomain proteins: TALEnted regulators of limb patterning and outgrowth. Dev Dyn 240: 1063-1086.
11. Mercader N, Leonardo E, Azpiazu N, Serrano A, Morata G, et al. (1999) Conserved regulation of proximodistal limb axis development by Meis1/Hth. Nature 402: 425-429.
12. Mercader N, Selleri L, Criado LM, Pallares P, Parras C, et al. (2009) Ectopic Meis1 expression in the mouse limb bud alters P-D patterning in a Pbx1-independent manner. Int J Dev Biol 53: 1483-1494.
13. Fognani C, Kilstrup-Nielsen C, Berthelsen J, Ferretti E, Zappavigna V, et al. (2002) Characterization of PREP2, a paralog of PREP1, which defines a novel sub-family of the MEINOX TALE homeodomain transcription factors. Nucleic Acids Res 30: 2043-2051.
14. Haller K, Rambaldi I, Kovacs EN, Daniels E, Featherstone M, (2002) Prep2: cloning and expression of a new prep family member. Dev Dyn 225: 358-364.
15. Coy SE, Borycki AG, (2010) Expression analysis of TALE family transcription factors during avian development. Dev Dyn 239: 1234-1245.
16. Ferretti E, Villaescusa JC, Di Rosa P, Fernandez-Diaz LC, Longobardi E, et al. (2006) Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype. Mol Cell Biol 26: 5650-5662.
17. Longobardi E, Iotti G, Di Rosa P, Mejetta S, Bianchi F, et al. (2010) Prep1 (pKnox1)-deficiency leads to spontaneous tumor development in mice and accelerates EmuMyc lymphomagenesis: a tumor suppressor role for Prep1. Mol Oncol 4: 126-134.
18. Logan M, Martin JF, Nagy A, Lobe C, Olson EN, et al. (2002) Expression of Cre Recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis 33: 77-80.
19. Long F, Zhang XM, Karp S, Yang Y, McMahon AP, (2001) Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development 128: 5099-5108.
20. Zha L, Hou N, Wang J, Yang G, Gao Y, et al. (2008) Collagen1alpha1 promoter drives the expression of Cre recombinase in osteoblasts of transgenic mice. J Genet Genomics 35: 525-530.
21. Guo X, Mak KK, Taketo MM, Yang Y, (2009) The Wnt/beta-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy and final maturation. PLoS One 4: e6067.
22. Zhu X, Zhu H, Zhang L, Huang S, Cao J, et al. (2012) Wls-mediated Wnts differentially regulate distal limb patterning and tissue morphogenesis. Dev Biol 365: 328-338.
23. Nelson CE, Morgan BA, Burke AC, Laufer E, DiMambro E, et al. (1996) Analysis of Hox gene expression in the chick limb bud. Development 122: 1449-1466.
24. Hill TP, Taketo MM, Birchmeier W, Hartmann C, (2006) Multiple roles of mesenchymal beta-catenin during murine limb patterning. Development 133: 1219-1229.
25. Yi SE, Daluiski A, Pederson R, Rosen V, Lyons KM, (2000) The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb. Development 127: 621-630.
26. Wahba GM, Hostikka SL, Carpenter EM, (2001) The paralogous Hox genes Hoxa10 and Hoxd10 interact to pattern the mouse hindlimb peripheral nervous system and skeleton. Dev Biol 231: 87-102.
27. Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, et al. (2010) An atlas of combinatorial transcriptional regulation in mouse and man. Cell 140: 744-752.
28. Hall BK, Miyake T, (2000) All for one and one for all: condensations and the initiation of skeletal development. Bioessays 22: 138-147.
29. Goff DJ, Tabin CJ, (1997) Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth. Development 124: 627-636.
30. Sanford LP, Ormsby I, Gittenberger-de Groot AC, Sariola H, Friedman R, et al. (1997) TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes. Development 124: 2659-2670.
31. Blitz E, Viukov S, Sharir A, Shwartz Y, Galloway JL, et al. (2009) Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction. Dev Cell 17: 861-873.
32. Knosp WM, Scott V, Bachinger HP, Stadler HS, (2004) HOXA13 regulates the expression of bone morphogenetic proteins 2 and 7 to control distal limb morphogenesis. Development 131: 4581-4592.
33. Williams TM, Williams ME, Heaton JH, Gelehrter TD, Innis JW, (2005) Group 13 HOX proteins interact with the MH2 domain of R-Smads and modulate Smad transcriptional activation functions independent of HOX DNA-binding capability. Nucleic Acids Res 33: 4475-4484.
34. Shi X, Yang X, Chen D, Chang Z, Cao X, (1999) Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling. J Biol Chem 274: 13711-13717.
35. Shi X, Bai S, Li L, Cao X, (2001) Hoxa-9 represses transforming growth factor-beta-induced osteopontin gene transcription. J Biol Chem 276: 850-855.
36. Bailey JS, Rave-Harel N, McGillivray SM, Coss D, Mellon PL, (2004) Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1. Mol Endocrinol 18: 1158-1170.