The effect of Persian shallot (Allium hirtifolium Boiss.) extract on blood sugar and serum levels of some hormones in diabetic rats

Pakistan Journal of Pharmaceutical Sciences

Volumn 26, Issue 2, 2013, Pages 397-402

  Mehdi, Mahmoodi ^a   Javad, Hosseini ^a   Seyed Mostafa, Hosseini Zijoud ^b   Mohammadreza, Mirzaee ^a   Ebrahim, Mirzajani ^c  

^a RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b HAMADAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c GUILAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Allium hirtifolium Boiss; Hormone; Insulin; Persian shallot; Type 1 diabetes

Indexed keywords

ANTIDIABETIC AGENT; ANTIOXIDANT; DIALLYL DISULFIDE; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C; INSULIN; LIOTHYRONINE; PERSIAN SHALLOT EXTRACT; PLANT EXTRACT; STREPTOZOCIN; THYROXINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DOSE RESPONSE; GLUCOSE BLOOD LEVEL; GLYCOGEN LIVER LEVEL; HEMOGLOBIN BLOOD LEVEL; HORMONE BLOOD LEVEL; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESPONSE; LIOTHYRONINE BLOOD LEVEL; MALE; NONHUMAN; PERSIAN SHALLOT; RADIOIMMUNOASSAY; RAT; SHALLOT; STREPTOZOCIN DIABETES; THYROXINE BLOOD LEVEL; TREATMENT DURATION;

ALLIUM; ANIMALS; BIOLOGICAL MARKERS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; HEMOGLOBIN A, GLYCOSYLATED; HORMONES; HYPOGLYCEMIC AGENTS; INSULIN; MALE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; PLANTS, MEDICINAL; RATS; RATS, WISTAR; SOLVENTS; STREPTOZOCIN; THYROXINE; TRIIODOTHYRONINE;

EID: 84878039489     PISSN: 1011601X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Ahmad MS and Ahmed N (2006). Antiglycation Properties of Aged Garlic Extract: Possible Role in Prevention of Diabetic Complications. J. Nutr., 136: 796-799.
2. Azuma K, Minami Y, Ippoushi K and Terao J (2007). Lowering effects of onion intake on oxidative stress biomarkers in streptozotocin-induced diabetic rats. J. Clin. Biochem. Nutr., 40: 131-140.
3. Baer-Dubowska W, Szaefer H and Krajka-Kuzniak V (1998). Inhibition of murine hepatic cytochrome P450 activities by natural and synthetic phenolic compounds. Xenobiotica., 28(8): 735-43.
4. Bessesen DH (2001). The role of carbohydrates in insulin resistance. J. Nutr., 31: 2782-2786.
5. Celik S, Erdogan S and Tuzcu M (2009). Caffeic acid phenethyl ester (CAPE) exhibits significant potential as an anti-diabetic and liver-protective agent in streptozotocin-induced diabetic rats. Pharmacol. Res., 60: 270-276.
6. Chandalia H and Krishnaswamy P (2002). Glycated hemoglobin. Curr. Sci., 83: 12.
7. Cheng AYY and Josse RG (2004). Intestinal absorption inhibitors for type 2 diabetes mellitus: Prevention and treatment. Drug Discov. Today Ther. Strateg., 1: 201-206.
8. Clement K, Viguerie N, Diehn M, Alizadeh A, Barbe P, Thalamas C, Storey J, Brown P, Barsh G and Langin D (2002). In vivo regulation of human skeletal muscle gene expression by thyroid hormone. Genome Res., 12: 281-91.
9. Crunkhorn S and Patti ME (2008). Links between thyroid hormone action, oxidative metabolism, and diabetes risk? Thyroid, 18: 227-237.
10. Ebrahimi R, Zamani Z, Kashi A and Jabbari A. (2008). Comparison of fatty acids, mineral elements of 17 Iranian Shallot Landraces (Allium hirtifolium Boiss.). JFST, 5: 61-68.
11. Gabriela B (2010). Diabetes and thyroid disorders. Br. J. of Diabetes and Vascular Medicine, 10: 172.
12. Haitoglou C, Tsilibary E, Brownlee M and Charonis A (1992). J. Biol. Chem., 267: 12404-12407.
13. Handisurya A, Pacini G, Tura A, Gessl A and Kautzky-Willer A (2008). Effects of T4 replacement therapy on glucose metabolism in subjects with subclinical (SH) and overt hypothyroidism (OH). Clin. Endocrinol., 69: 963-969.
14. Hosseini J, Hosseini-zijoud SM, Oubari F, Mahmoodi M, Abbasi E, Rajabi N, Ghasemi SR and Hashemi B (2012). Hepatoprotective effects of hydroalcoholic extract of Allium hirtifolium (Persian shallot) in diabetic rats. J. Basic Clin. Physiol. Pharmacol., 23(2): 83-87.
15. Kavalali G, Tuncel H, Göksel S and Hatemi HH (2002). Hypoglycemic activity of Urtica pilulifera in streptozotocin-diabetic rats. J. Ethnopharmacol., 84(2): 241-245
16. Kodera Y, Suzuki A, Imada O, Kasuga S, Sumioka I, Kanezawa A, Taru N, Fujikawa M, Nagae S, Masamoto K, Maeshige K and Ono K (2002). Chemical and biological properties of s-allylcysteine, an amino acid derived from garlic. J. Agric. Food Chem., 50: 622-632.
17. Leahy JL (2005). Pathogenesis of type 2 diabetes mellitus. Arch. Med. Res., 36: 197-209.
18. Leelarungrayub N, Chanarat N and Rattanapanone V (2004). Potential activity of Thai shallot (Allium Ascalonicum L.) extract on the prevention of hemolysis and glutathione depletion in human erythrocyte from oxidative stress. CMU J., 3: 225-234.
19. Leelarungrayub N, Rattanapanone V, Chanarat N and Gebicki JM (2006). Quantitative evaluation of the antioxidant properties of garlic and shallot preparations. Nutr, 22: 266-274.
20. Mahmoodi M, Hosseini Zijoud SM, Hassanshahi G, Toghroli M, Khaksari M, Hajizadeh M and Mirzajani E (2011). The effects of consumption of raw garlic on serum lipid level, blood sugar and a number of effective hormones on lipid and sugar metabolism in hyperglycemic and/or hyperlipidemia individuals. ABC, 1: 29-33.
21. th ed., Reza Press, Tehran, pp.43-47.
22. Nakagawa T, Yokozawa T, Terasawa K, Shu S and Juneja LR (2002). Protective activity of green tea against free radical-and glucose-mediated protein damage. J. Agric. Food Chem., 50: 2418-2422.
23. Padiya R, Khatua T, Bagul P, Kuncha M and Banerjee S (2011). Garlic improves insulin sensitivity and associated metabolic syndromes in fructose fed rats. J. Nutr. Metab., 8: 53-61.
24. Pearce SH and Merriman TR (2009). Genetics of type 1 diabetes and autoimmune thyroid disease. Endocrinol Metab. Clin. N. Am., 38: 289-301.
25. Perros P, McCrimmon RJ, Shaw G and Frier BM (1995). Frequency of thyroid dysfunction in diabetic patients: value of annual screening. Diabet Med., 12: 622-627.
26. Queiroz YS, Ishimoto E Y, Bastos DH, Sampaio GR and Torres EA (2009). Garlic (Allium sativum L.) and ready-to-eat garlic products: In vitro antioxidant activity. Food Chem., 115: 371-374.
27. Terrance L, Charles G, Larry F, William KH, Jose C and Vicente N (1992). Molecular Characterization of quercetin and quercetin glycosides in Allium vegetables. Their effects on malignant cell transformation. ACS Symp Ser., 50: 220-238.