Effects of T4 replacement therapy on glucose metabolism in subjects with subclinical (SH) and overt hypothyroidism (OH)

Clinical Endocrinology

Volumn 69, Issue 6, 2008, Pages 963-969

  Handisurya, Ammon ^a   Pacini, Giovanni ^b   Tura, Andrea ^b   Gessl, Alois ^a   Kautzky Willer, Alexandra ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; LEVOTHYROXINE SODIUM; PROINSULIN; THYREX; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CARBOHYDRATE METABOLISM; CELL FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HORMONE BLOOD LEVEL; HORMONE SUBSTITUTION; HUMAN; HYPOTHYROIDISM; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN SENSITIVITY; MALE; ORAL GLUCOSE TOLERANCE TEST; OVERT HYPOTHYROIDISM; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REGULATORY MECHANISM; SUBCLINICAL HYPOTHYROIDISM; THYROID FUNCTION;

ADULT; BLOOD GLUCOSE; FEMALE; GLUCOSE; GLUCOSE TOLERANCE TEST; HORMONE REPLACEMENT THERAPY; HUMANS; HYPOTHYROIDISM; INSULIN; INSULIN-SECRETING CELLS; MALE; MIDDLE AGED; THYROXINE;

EID: 55849094579     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2008.03280.x     Document Type: Article

References (33)

1. Hollowell, J.G., Staehling, N.W., Flanders, W.D., Hannon, W.H., Gunter, E.W., Spencer, C.A. Braverman, L.E. (2002) Serum TSH, T4, and thyroid antibodies in the United States Population (1988-94): National Health and Nutrition Examination Survey (NHANES III). Journal of Clinical Endocrinology and Metabolism, 87, 489 499.
2. Dimitriadis, G.D. Raptis, S.A. (2001) Thyroid hormone excess and glucose intolerance. Experimental and Clinical Endocrinology and Diabetes, 109, S225 S239.
3. Brenta, G., Berg, G., Arias, P., Zago, V., Schnitman, M., Muzzio, M.L., Sinay, I. Schreier, L. (2007) Lipoprotein alterations, hepatic lipase activity, and insulin sensitivity in subclinical hypothyroidism: response to 1-t (4) treatment. Thyroid, 17, 453 460.
4. Owecki, M., Nikisch, E. Sowinski, J. (2006) Hypothyroidism has no impact on insulin sensitivity assessed with HOMA-IR in totally thyroidectomized patients. Acta Clinica Belgica, 61, 69 73.
5. Dessein, P.H., Joffe, B.I. Stanwix, A.E. (2004) Subclinical hypothyroidism is associated with insulin resistance in rheumatoid arthritis. Thyroid, 14, 443 446.
6. Stanicka, S., Vondra, K., Pelikanova, T., Vlcek, P., Hill, M. Zamrazil, V. (2005) Insulin sensitivity and counter-regulatory hormones in hypothyroidism and during thyroid hormone replacement therapy. Clinical Chemistry and Laboratory Medicine, 43, 715 720.
7. Rochon, C., Tauveron, I., Dejax, C., Benoit, P., Capitan, P., Fabricio, A., Berry, C., Champredon, C., Thieblot, P. Grizard, J. (2003) Response of glucose disposal to hyperinsulinaemia in human hypothyroidism and hyperthyroidism. Clinical Science, 104, 7 15.
8. DeFronzo, R.A., Tobin, J.D. Andres, R. (1979) Glucose clamp technique: a method for quantifying insulin secretion and resistance. American Journal of Physiology, 237, E214 E232.
9. Waldhäusl, W., Herkner, K., Nowotny, P. Bratusch-Marrain, P. (1978) Combined 17- and 18-hydroxylase deficiency associated with complete male pseudohermaphrodism and hypoaldosteronism. Journal of Clinical Endocrinology and Metabolism, 46, 236 241.
10. Thomaseth, K., Kautzky-Willer, A., Ludvik, B., Prager, R. Pacini, G. (1996) Integrated mathematical model to assess β-cell activity during the oral glucose test. American Journal of Physiology, 270, E522 E531.
11. Tura, A., Pacini, G., Kautzky-Willer, A., Ludvik, B., Prager, R. Thomaseth, K. (2003) Basal and dynamic proinsulin-insulin relationship to assess β-cell function during OGTT in metabolic disorders. American Journal of Physiology, Endocrinology and Metabolism, 285, E155 E162.
12. Ahrén, B. Pacini, G. (2004) Importance of quantifying insulin secretion in relation to insulin sensitivity to accurately assess β cell function in clinical studies. European Journal of Endocrinology, 150, 97 104.
13. Ahrén, B. Pacini, G. (1997) Impaired adaptation of first-phase insulin secretion in postmenopausal women with glucose intolerance. American Journal of Physiology, 273, E701 E707.
14. Kahn, S.E., Prigeon, R.L., McCulloch, D.K., Boyko, E.J., Bergman, R.N., Schwartz, M.W., Neifing, J.L., Ward, W.K., Beard, J.C., Palmer, J.P. Porte, D. Jr. (1993) Quantification of the relationship between insulin sensitivity and β-cell function in human subjects. Evidence for a hyperbolic function. Diabetes, 42, 1663 1672.
15. Stadler, M., Anderwald, C., Karer, T., Tura, A., Kästenbauer, T., Auinger, M., Bieglmayer, C., Wagner, O., Kronenberg, F., Nowotny, P., Pacini, G. Prager, R. (2006) Increased plasma amylin in type 1 diabetic patients after kidney and pancreas transplantation. A sign of impaired β-cell function? Diabetes Care, 29, 1031 1038.
16. Kautzky-Willer, A., Thomaseth, K., Clodi, M., Ludvik, B., Waldhäusl, W., Prager, R. Pacini, G. (1996) β-cell activity and hepatic insulin extraction following dexamethasone administration in healthy subjects. Metabolism, 45, 486 491.
17. Romero, R., Casanova, B., Pulido, N., Suarez, A.I. Rodriguez, E. (2000) Stimulation of glucose transport by thyroid hormone in 3T3-L1 adipocytes: increased abundance of GLUT1 and GLUT4 glucose transporter proteins. Journal of Endocrinology, 164, 187 195.
18. Torrance, C.J., Devente, J.E., Jones, J.P. Dohm, G.L. (1997) Effects of thyroid hormone on GLUT4 glucose transporter gene expression and NIDDM in rats. Endocrinology, 138, 1204 1214.
19. Weinstein, S.P., O'Boyle, E., Fisher, M. Haber, R.S. (1994) Regulation of GLUT2 glucose transporter expression in liver by thyroid hormone: Evidence for hormonal regulation of the hepatic glucose transport system. Endocrinology, 135, 649 654.
20. Boden, G. Laakso, M. (2004) Lipids and glucose in type 2 diabetes. Diabetes Care, 27, 2253 2259.
21. Huang, M.T. Lardy, H.A. (1981) Effects of thyroid states on the Cori cycle, glucose-alanine cycle, and futile cycling of glucose metabolism in rats. Archives of Biochemistry and Biophysics, 209, 41 51.
22. 3H-labeled glucose. Biochemical Journal, 182, 565 575.
23. Müller, M.J. Seitz, H.J. (1981) Starvation-induced changes of hepatic glucose metabolism in hypo- and hyperthyroid rats in vivo. Journal of Nutrition, 111, 1370 1379.
24. Bicikova, M., Hampl, R., Hill, M., Stanicka, S., Tallova, J. Vondra, K. (2003) Steroids, sex hormone-binding globulin, homocysteine, selected hormones and markers of lipid and carbohydrate metabolism in patients with severe hypothyroidism and their changes following thyroid hormone supplementation. Clinical Chemistry and Laboratory Medicine, 41, 284 292.
25. Müller, M.J., von Schütz, B., Huhnt, H.J., Zick, R., Mitzkat, H.J. von zur Mühlen, A. (1986) Glucoregulatory function of thyroid hormones: interactions with insulin depends on the prevailing glucose concentration. Journal of Clinical Endocrinology and Metabolism, 63, 62 71.
26. Zimmermann, R., Strauss, J.G., Haemmerle, G., Schoiswohl, G., Birner-Gruenberger, R., Riederer, M., Lass, A., Neuberger, G., Eisenhaber, F., Hermetter, A. Zechner, R. (2004) Fat mobilzation in adipose tissue is promoted by adipose triglyceride lipase. Science, 306, 1383 1386.
27. Coppack, S.W., Jensen, M.D. Miles, J.M. (1994) The in vivo regulation of lipolysis in humans. Journal of Lipid Research, 35, 177 193.
28. Caraccio, N., Natali, A., Sironi, A., Baldi, S., Frascerra, S., Dardano, A., Monzani, F. Ferrannini, E. (2005) Muscle metabolism and exercise tolerance in subclinical hypothyroidism: a controlled trial of levothyroxine. Journal of Clinical Endocrinology and Metabolism, 90, 4057 4062.
29. Meier, J.J., Veldhuis, J.D. Butler, P.C. (2005) Pulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humans. Diabetes, 54, 1649 1656.
30. Kim, S.P., Ellmerer, M., Kirkman, E.L. Bergman, R.N. (2007) β-cell 'rest' accompanies reduced first-pass hepatic insulin extraction in the insulin-resistant, fat-fed canine model. American Journal of Physiology, Endocrinology and Metabolism, 292, E1581 E1589.
31. Santomauro, A.T.M.G., Boden, G., Silva, M.E.R., Rocha, D.M., Santos, R.F., Ursich, M.J.M., Strassmann, P.G. Wajchenberg, B.L. (1999) Overnight lowering of free fatty acids with acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects. Diabetes, 48, 1836 1841.
32. Dimitriadis, G., Mitrou, P., Lambadiari, V., Boutati, E., Maratou, E., Panagiotakos, D.B., Koukkou, E., Tzanela, M., Thalassinos, N. Raptus, S.A. (2006) Insulin action in adipose tissue and muscle in hypothyroidism. Journal of Clinical Endocrinology and Metabolism, 91, 4930 4937.
33. Helfand, M. (2004) Screening for subclinical thyroid dysfunction in nonpregnant adults: a summary of the evidence for the U.S. Preventive Services Task Force. Annals of Internal Medicine, 140, 128 141.