Towards further reduction and replacement of animal bioassays in prion research by cell and protein misfolding cyclic amplification assays

Laboratory Animals

Volumn 47, Issue 2, 2013, Pages 106-115

  Boerner, Susann ^a   Wagenfüh, Katja ^a   Daus, Martin L ^a   Thomzig, Achim ^a   Beekes, Michael ^a  

^a ROBERT KOCH INSTITUTE   (Germany)

Author keywords

Cell assay; Prion; Prion protein; Protein misfolding cyclic amplification (PMCA); Reduction of animal bioassays

Indexed keywords

PRION PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOASSAY; CELL ASSAY; CONTROLLED STUDY; GENE AMPLIFICATION; GLIA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; NONHUMAN; PRION; PROTEIN MISFOLDING CYCLIC AMPLIFICATION; PROTEIN UNFOLDING; RELIABILITY;

ANIMALS; BIOLOGICAL ASSAY; BLOTTING, WESTERN; CATTLE; CATTLE DISEASES; CREUTZFELDT-JAKOB SYNDROME; CRICETINAE; DISINFECTION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENCEPHALOPATHY, BOVINE SPONGIFORM; HUMANS; NEUROGLIA; PRION DISEASES; PROTEIN ENGINEERING; PROTEIN FOLDING; PRPC PROTEINS; PRPSC PROTEINS; SCRAPIE; SENSITIVITY AND SPECIFICITY; SHEEP;

EID: 84878038911     PISSN: 00236772     EISSN: None     Source Type: Journal    
DOI: 10.1177/0023677213476856     Document Type: Article

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