The effect of diagnosis, age, and symptom severity on cortical surface area in the cingulate cortex and insula in autism spectrum disorders

Journal of Child Neurology

Volumn 28, Issue 6, 2013, Pages 729-736

  Doyle Thomas, Krissy A R ^a   Kushki, Azadeh ^a   Duerden, Emma G ^b   Taylor, Margot J ^b   Lerch, Jason P ^b,c   Soorya, Latha V ^d   Wang, A Ting ^d   Fan, Jin ^d   Anagnostou, Evdokia ^a  

^a University of Toronto   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c Toronto Centre for Phenogenomics   (Canada)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

autism spectrum disorders; cingulate cortex and insula; structural MRI; surface morphometry

Indexed keywords

ADOLESCENT; ADULT; AGE; ARTICLE; AUTISM; CHILD; CINGULATE CORTEX SURFACE AREA; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GRAY MATTER; HUMAN; INSULA; INSULA SURFACE AREA; INTELLIGENCE QUOTIENT; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SCHOOL CHILD; SOCIAL BEHAVIOR; SOCIAL STATUS; SYMPTOMATOLOGY; TASK PERFORMANCE; WECHSLER INTELLIGENCE SCALE; WHITE MATTER; ATROPHY; AUTISM SPECTRUM DISORDERS; BRAIN CORTEX; CINGULATE CORTEX AND INSULA; COMPUTER ASSISTED DIAGNOSIS; HEMISPHERIC DOMINANCE; ORGAN SIZE; PARAHIPPOCAMPAL GYRUS; PATHOLOGY; PHYSIOLOGY; PRESCHOOL CHILD; PSYCHOLOGICAL ASPECT; REFERENCE VALUE; SOCIAL ADAPTATION; STRUCTURAL MRI; SURFACE MORPHOMETRY;

AUTISM SPECTRUM DISORDERS; CINGULATE CORTEX AND INSULA; STRUCTURAL MRI; SURFACE MORPHOMETRY;

ADOLESCENT; AGE FACTORS; ATROPHY; CEREBRAL CORTEX; CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; CHILD, PRESCHOOL; DOMINANCE, CEREBRAL; FEMALE; GYRUS CINGULI; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; ORGAN SIZE; PARAHIPPOCAMPAL GYRUS; REFERENCE VALUES; SOCIAL ADJUSTMENT; YOUNG ADULT;

EID: 84878026178     PISSN: 08830738     EISSN: 17088283     Source Type: Journal    
DOI: 10.1177/0883073812451496     Document Type: Article

References (75)

1. Baron-Cohen S Understanding Other Minds: Perspectives From Developmental Cognitive Neuroscience. 2 nd ed. New York: Oxford University Press; 2000:530. Baron-Cohen S Tager-Flusberg H Cohen DJ, ed. New York: Oxford University Press ; 2000: 530.
2. Baron-Cohen S. Theory of mind and autism: a review. Int Rev Res Ment Ret. 2000 ; 23: 169-184
3. Allman JM, Watson KK, Tetreault NA, Hakeem AY. Intuition and autism: a possible role for von Economo neurons. Trends Cogn Sci. 2005 ; 9 (8). 367-373
4. Silani G, Bird G, Brindley R, Singer T, Frith C, Frith U. Levels of emotional awareness and autism: an fMRI study. Soc Neurosci. 2008 ; 3 (2). 97-112
5. Critchley HD, Daly EM, Bullmore ET, et al. The functional neuroanatomy of social behaviour: changes in cerebral blood flow when people with autistic disorder process facial expressions. Brain. 2000 ; 123: 2203-2212
6. Baron-Cohen S, Belmonte MK. Autism: a window onto the development of the social and the analytic brain. Annu Rev Neurosci. 2005 ; 28: 109-126
7. Amaral DG, Schumann CM, Nordahl CW. Neuroanatomy of autism. Trends Neurosci. 2008 ; 31 (3). 137-145
8. Happe F, Ehlers S, Fletcher P, et al. Theory of mind in the brain: evidence from a PET scan study of Asperger syndrome. Neuroreport. 1996 ; 8: 197-201
9. Dalton KM, Nacewicz BM, Johnstone T, et al. Gaze fixation and the neural circuitry of face processing in autism. Nat Neurosci. 2005 ; 8 (4). 519-526
10. Gervais H, Belin P, Boddaert N, et al. Abnormal cortical voice processing in autism. Nat Neurosci. 2004 ; 7 (8). 801-802
11. Boddaert N, Chabane N, Gervais H, et al. Superior temporal sulcus anatomical abnormalities in childhood autism: a voxel-based morphometry MRI study. Neuroimage. 2004 ; 23 (1). 364-369
12. Pelphrey KA, Carter EJ. Brain mechanisms for social perception: lessons from autism and typical development. Ann N Y Acad Sci. 2008 ; 1145: 283-299
13. Pierce K, Müller RA, Ambrose J, Allen G, Courchesne E. Face processing occurs outside the fusiform 'face area' in autism: evidence from functional MRI. Brain. 2001 ; 124: 2059-2073
14. Wang AT, Dapretto M, Hariri AR, Sigman M, Bookheimer SY. Neural correlates of facial affect processing in children and adolescents with autism spectrum disorder. J Am Acad Child Adolesc Psychiatry. 2004 ; 43 (4). 481-490
15. Abell F, Krams M, Ashburner J, et al. The neuroanatomy of autism: a voxel-based whole brain analysis of structural scans. Neuroreport. 1999 ; 10 (8). 1647-1651
16. Baron-Cohen S, Ring HA, Wheelwright S, et al. Social intelligence in the normal and autistic brain: an fMRI study. Eur J Neurosci. 1999 ; 11 (6). 1891-1898
17. Aylward EH, Minshew NJ, Goldstein G, et al. MRI volumes of amygdala and hippocampus in non-mentally retarded autistic adolescents and adults. Neurology. 1999 ; 53 (9). 2145-2150
18. Howard MA, Cowell PE, Boucher J, et al. Convergent neuroanatomical and behavioural evidence of an amygdala hypothesis of autism. Neuroreport. 2000 ; 11 (13). 2931-2935
19. Sparks BF, Friedman SD, Shaw DW, et al. Brain structural abnormalities in young children with autism spectrum disorder. Neurology. 2002 ; 59 (2). 184-192
20. Bauman ML, Kemper TL. Neuroanatomic observations of the brain in autism: a review and future directions. Int J Dev Neurosci. 2005 ; 23 (2-3). 183-187
21. Devinsky O, Morrell MJ, Vogt BA. Contributions of anterior cingulate cortex to behaviour. Brain. 1995 ; 118: 279-306
22. Carter CS, Braver TS, Barch DM, Botvinick MM, Noll D, Cohen JD. Anterior cingulate cortex, error detection, and the online monitoring of performance. Science. 1998 ; 280 (5364). 747-749
23. Botvinick M, Nystrom LE, Fissell K, Carter CS, Cohen JD. Conflict monitoring versus selection-for-action in anterior cingulate cortex. Nature. 1999 ; 402 (6758). 179-181
24. Bush G, Luu P, Posner MI. Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci. 2000 ; 4 (6). 215-222
25. Botvinick MM, Cohen JD, Carter CS. Conflict monitoring and anterior cingulate cortex: an update. Trends Cogn Sci. 2004 ; 8 (12). 539-546
26. Lane RD, Reiman EM, Axelrod B, Yun LS, Holmes A, Schwartz GE. Neural correlates of levels of emotional awareness: evidence of an interaction between emotion and attention in the anterior cingulate cortex. J Cogn Neurosci. 1998 ; 10 (4). 525-535
27. Allman JM, Hakeem A, Erwin JM, Nimchinsky E, Hof P. The anterior cingulate cortex: the evolution of an interface between emotion and cognition. Ann N Y Acad Sci. 2001 ; 935: 107-117
28. Santos M, Uppal N, Butti C, et al. Von Economo neurons in autism: a stereologic study of the frontoinsular cortex in children. Brain Res. 2011 ; 1380: 206-217
29. Butti C, Santos M, Uppal N, Hof PR.. Von Economo neurons: clinical and evolutionary perspectives. Cortex. 2011 ;:
30. Craik FIM, Moroz TM, Moscovitch M, et al. In search of the self: a positron emission tomography study. Psychol Sci. 1999 ; 10 (1). 26-34
31. Frith CD, Frith U. Interacting minds: a biological basis. Science. 1999 ; 286 (5445). 1692-1695
32. Johnson SC, Baxter LC, Wilder LS, Pipe JG, Heiserman JE, Prigatano GP. Neural correlates of self-reflection. Brain. 2002 ; 125: 1808-1814
33. Mundy P. Annotation: the neural basis of social impairments in autism. The role of the dorsal medial-frontal cortex and anterior cingulate system. J Child Psychol Psychiatry. 2003 ; 44 (6). 793-809
34. Mufson EJ, Mesulam MM.. Insula of the old world monkey, II: afferent cortical input and comments on the claustrum. J Comp Neurol. 1982 ; 212 (1). 23-37
35. Vogt BA, Pandya DN. Cingulate cortex of the rhesus monkey, II: cortical afferents. J Comp Neurol. 1987 ; 262 (2). 271-289
36. Augustine JR. Circuitry and functional aspects of the insular lobe in primates including humans. Brain Res Brain Res Rev. 1996 ; 22 (3). 229-244
37. Craig AD. How do you feel-now? The anterior insula and human awareness. Nat Rev Neurosci.. 2009 ; 10 (1). 59-70
38. Dapretto M, Davies MS, Pfeifer JH, et al. Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders. Nat Neurosci. 2006 ; 9 (1). 28-30
39. Craig AD. Interoception: the sense of the physiological condition of the body. Curr Opin Neurobiol. 2003 ; 13 (4). 500-505
40. Iacoboni M, Dapretto M. The mirror neuron system and the consequences of its dysfunction. Nat Rev Neurosci. 2006 ; 7 (12). 942-951
41. Rakic P. Specification of cerebral cortical areas. Science. 1988 ; 241 (4862). 170-176
42. Rakic P. Radial versus tangential migration of neuronal clones in the developing cerebral cortex. Proc Natl Acad Sci U S A. 1995 ; 92 (25). 11323-11327
43. Reiss AL, Abrams MT, Singer HS, Ross JL, Denckla MB. Brain development, gender and IQ in children: a volumetric imaging study. Brain. 1996 ; 119: 1763-1774
44. Sowell ER, Delis D, Stiles J, Jernigan TL. Improved memory functioning and frontal lobe maturation between childhood and adolescence: a structural MRI study. J Int Neuropsychol Soc. 2001 ; 7 (3). 312-322
45. Diagnostic and Statistical Manual of Mental Disorders. 4 th ed. Washington, DC: American Psychiatric Association; 1994. Washington, DC: American Psychiatric Association ; 1994 :
46. Lord C, Risi S, Lambrecht L, et al. The Autism Diagnostic Observation Schedule-Generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord. 2000 ; 30: 205-223
47. Lord C, Rutter M, Le Couteur A. Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord. 1994 ; 24: 659-685
48. Wechsler D Manual for the Wechsler Intelligence Scale for Children (WISC-IV). 4 th ed. San Antonio, TX: Psychological Corporation; 2003. San Antonio, TX: Psychological Corporation ; 2003 :
49. Wechsler D Wechsler Adult Intelligence Scale. 4 th ed. San Antonio, TX: Pearson; 2008. San Antonio, TX: Pearson ; 2008 :
50. Ad-Dab'bagh Y, Lyttelton O, Muehlboeck JS, et al NeuroImage. Corbetta M, ed. Florence, Italy: ; 2006: 2266.
51. Zijdenbos AP, Forghani R, Evans AC. Automatic "pipeline" analysis of 3-D MRI data for clinical trials: application to multiple sclerosis. IEEE Trans Med Imaging. 2002 ; 21: 1280-1291
52. Kim JS, Singh V, Lee JK, et al. Automated 3-D extraction and evaluation of the inner and outer cortical surfaces using a Laplacian map and partial volume effect classification. Neuroimage. 2005 ; 27: 210-221
53. Lee JK, Lee J-M, Kim JS, et al. A novel quantitative cross-validation of different cortical surface reconstruction algorithms using MRI phantom. Neuroimage. 2006 ; 31: 572-584
54. RobbinsSM. Anatomical Standardization of the Human Brain in Euclidean 3-Space and on the Cortical 2-Manifold. PhD thesis. Montreal: School of Computer Science, McGill University; 2003.
55. Robbins S, Evans AC, Collins DL, et al. Tuning and comparing spatial normalization methods. Med Image Anal. 2004 ; 8: 311-323
56. Lyttelton O, Boucher M, Robbins S, et al. An unbiased iterative group registration template for cortical surface analysis. Neuroimage. 2007 ; 34: 1535-1544
57. Toga AW, Thompson PM, Sowell ER. Mapping brain maturation. Trends Neurosci. 2006 ; 29: 148-159
58. Gogtay N, Giedd JN, Lusk L, et al. Dynamic mapping of human cortical development during childhood through early adulthood. Proc Natl Acad Sci U S A. 2004 ; 101: 8174-8179
59. Mak-Fan KM, Taylor MJ, Roberts W, Lerch JP. Measures of cortical grey matter structure and development in children with autism spectrum disorder. J Autism Dev Disord. 2012 ; 42: 419-427
60. Hardan AY, Jou RJ, Keshavan MS, et al. Increased frontal cortical folding in autism: a preliminary MRI study. Psych Res. 2004 ; 131: 263-268
61. Raznahan A, Toro R, Daly E, et al. Cortical anatomy in autism spectrum disorder: an in vivo MRI study on the effect of age. Cereb Cortex. 2010 ; 20 (6). 1332-1340
62. Dove A, Pollmann S, Schubert T, Wiggins CJ, von Cramon DY. Prefrontal cortex activation in task switching: an event-related fMRI study. Brain Res Cogn Brain Res. 2000 ; 9 (1). 103-109
63. Eckert MA, Menon V, Walczak A, et al. At the heart of the ventral attention system: the right anterior insula. Hum Brain Mapp. 2009 ; 30 (8). 2530-2541
64. Naidich TP, Daniels DL, Haughton VM, et al. Hippocampal formation and related structures of the limbic lobe: anatomic-MR correlation. Part I: surface features and coronal sections. Radiology. 1987 ; 162 (3). 747-754
65. Hirai T, Korogi Y, Yoshizumi K, et al. Limbic lobe of the human brain: evaluation with turbo fluid-attenuated inversion-recovery MR imaging. Radiology. 2000 ; 215 (2). 470-475
66. Isaacson RL The Limbic System. 2 nd ed. New York: Plenum Press; 1982. New York: Plenum Press ; 1982 :
67. Colby CL, Goldberg ME. Space and attention in parietal cortex. Annu Rev Neurosci. 1999 ; 22: 319-349
68. Cohen YE. Multimodal activity in the parietal cortex. Hearing Res. 2009 ; 258: 100-105
69. Monti MM, Parsons LM, Osherson DN.. The boundaries of language and thought in deductive inference. Proc Natl Acad Sci U S A. 2009 ; 106: 12554-12559
70. Hoenig K, Scheef L. Neural correlates of semantic ambiguity processing during context verification. Neuroimage. 2009 ; 15: 1009-1019
71. Olson IR, Plotzker A, Ezzyat Y. The Enigmatic temporal pole: a review of findings on social and emotional processing. Brain. 2007 ; 130: 1718-1731
72. Nordahl CW, Dierker D, Mostafavi I, et al. Cortical folding abnormalities in autism revealed by surface-based morphometry. J Neurosci. 2007 ; 27: 11725-11735
73. Shaw P, Kabani NJ, Lerch JP, et al. Neurodevelopmental trajectories of the human cerebral cortex. J Neurosci. 2008 ; 28 (14). 3586-3594
74. Levitt JG, Blanton RE, Smalley S, et al. Cortical sulcal maps in autism. Cereb Cortex. 2003 ; 13: 728-735
75. Courchesne E, Mouton PR, Calhoun ME, et al. Neuron number and size in prefrontal cortex of children with autism. JAMA. 2011 ; 306 (18). 2001-2010