In vivo studies of brain metabolism in animal models of Hepatic Encephalopathy using 1H Magnetic Resonance Spectroscopy

Metabolic Brain Disease

Volumn 28, Issue 2, 2013, Pages 167-174

  Cudalbu, Cristina ^a  

^a EPFL   (Switzerland)

Author keywords

Acute liver failure; Chronic liver disease; Hepatic encephalopathy; Hyperammonemia; In vivo short echo time 1H MRS; Quantification of neurochemical profile

Indexed keywords

ACUTE LIVER FAILURE; BRAIN METABOLISM; CHRONIC LIVER DISEASE; CONFERENCE PAPER; HEPATIC ENCEPHALOPATHY; HYPERAMMONEMIA; IN VIVO STUDY; MAGNETIC FIELD; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; ANIMAL; BRAIN; BRAIN LEVEL; ELECTROMAGNETIC FIELD; END STAGE LIVER DISEASE; HUMAN; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSIOLOGY; PROCEDURES;

ANIMALIA;

ANIMALS; BRAIN; BRAIN CHEMISTRY; ELECTROMAGNETIC FIELDS; END STAGE LIVER DISEASE; HEPATIC ENCEPHALOPATHY; HUMANS; HYPERAMMONEMIA; LIVER FAILURE, ACUTE; MAGNETIC RESONANCE SPECTROSCOPY;

EID: 84878018658     PISSN: 08857490     EISSN: 15737365     Source Type: Journal    
DOI: 10.1007/s11011-012-9368-9     Document Type: Conference Paper

References (55)

1. Albrecht J, Norenberg MD (2006) Glutamine: a Trojan horse in ammonia neurotoxicity. Hepatology 44(4):788-794
2. Bates TE, Williams SR, Kauppinen RA, Gadian DG (1989) Observation of cerebral metabolites in an animal-model of acute liver-failure invivo - a H-1 and P-31 nuclear magnetic-resonance study. J Neurochem 53(1):102-110
3. Berl S, Takagaki G, Clarke DD, Waelsch H (1962) Metabolic compartments in vivo. Ammonia and glutamic acid metabolism in brain and liver. J Biol Chem 237:2562-2569
4. Bosman DK, Deutz NE, De Graaf AA, van den Hulst RW, Van Eijk HM, Bovee WM, Maas MA, Jorning GG, Chamuleau RA (1990) Changes in brain metabolism during hyperammonemia and acute liver failure: results of a comparative 1H-NMR spectroscopy and biochemical investigation. Hepatology 12(2):281-290
5. Braissant O, McLin VA, Cudalbu C (2012) Ammonia toxicity to the brain. J Inherit Metab Dis Oct 30. [Epub ahead of print]
6. Brand A, Richter-Landsberg C, Leibfritz D (1993) Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. Dev Neurosci 15(3-5):289-298
7. Brusilow SW, Traystman R (1986) Hepatic encephalopathy. N Engl J Med 314(12):786-787, author reply 787
8. Brusilow SW, Koehler RC, Traystman RJ, Cooper AJ (2010) Astrocyte glutamine synthetase: importance in hyperammonemic syndromes and potential target for therapy. Neurotherapeutics 7(4):452-470
9. Butterworth RF (2003) Pathogenesis of hepatic encephalopathy: new insights from neuroimaging and molecular studies. J Hepatol 39(2):278-285
10. Cagnon L, Braissant O (2007) Hyperammonemia-induced toxicity for the developing central nervous system. Brain Res Rev 56(1):183-197
11. Caudle SE, Katzenstein JM, Karpen SJ, McLin VA (2010) Language and motor skills are impaired in infants with biliary atresia before transplantation. J Pediatr 156(6):936-940, 940 e931
12. Cauli O, Lopez-Larrubia P, Rodrigues TB, Cerdan S, Felipo V (2007) Magnetic resonance analysis of the effects of acute ammonia intoxication on rat brain. Role of NMDA receptors. J Neurochem 103(4):1334-1343
13. Cauli O, Lopez-Larrubia P, Rodrigo R, Agusti A, Boix J, Nieto-Charques L, Cerdan S, Felipo V (2011) Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats. Gastroenterology 140(2):638-645
14. Chatauret N, Zwingmann C, Rose C, Leibfritz D, Butterworth RF (2003) Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study. Gastroenterology 125(3):815-824
15. Chavarria L, Oria M, Romero-Gimenez J, Alonso J, Lope-Piedrafita S, Cordoba J (2010) Diffusion tensor imaging supports the cytotoxic origin of brain edema in a rat model of acute liver failure. Gastroenterology 138(4):1566-1573
16. Cooper AJ (2011) 13 N as a tracer for studying glutamate metabolism. Neurochem Int 59(4):456-464
17. Cooper AJ (2012) The role of glutamine synthetase and glutamate dehydrogenase in cerebral ammonia homeostasis. Neurochem Res 37(11):2439-2455
18. Cooper AJ, Plum F (1987) Biochemistry and physiology of brain ammonia. Physiol Rev 67(2):440-519
19. Cordoba J (1996) Glutamine, myo-inositol, and brain edema in acute liver failure. Hepatology 23(5):1291-1292
20. Cordoba J, Gottstein J, Blei AT (1996) Glutamine, myo-inositol, and organic brain osmolytes after portocaval anastomosis in the rat: implications for ammonia-induced brain edema. Hepatology 24(4):919-923. doi: 10.1002/hep.510240427
21. Cordoba J, Gottstein J, Blei AT (1998) Chronic hyponatremia exacerbates ammonia-induced brain edema in rats after portacaval anastomosis. J Hepatol 29(4):589-594
22. Cordoba J, Alonso J, Rovira A, Jacas C, Sanpedro F, Castells L, Vargas V, Margarit C, Kulisewsky J, Esteban R, Guardia J (2001) The development of low-grade cerebral edema in cirrhosis is supported by the evolution of (1)H-magnetic resonance abnormalities after liver transplantation. J Hepatol 35(5):598-604
23. Cordoba J, Sanpedro F, Alonso J, Rovira A (2002) 1H magnetic resonance in the study of hepatic encephalopathy in humans. Metab Brain Dis 17(4):415-429
24. Cudalbu C, Cavassila S, Rabeson H, van Ormondt D, Graveron-Demilly D (2008) Influence of measured and simulated basis sets on metabolite concentration estimates. NMR Biomed 21(6):627-636
25. Cudalbu C, Mlynarik V, Xin L, Gruetter R (2009) Comparison of T1 relaxation times of the neurochemical profile in rat brain at 9.4 tesla and 14.1 tesla. Magn Reson Med 62(4):862-867
26. Cudalbu C, Mlynárik V, Lanz B, Frenkel H, Costers N, Gruetter R (2010) Imaging glutamine synthesis rates in the hyperammonemic rat brain. In: Proc Intl Soc Mag Reson Med 18:3324
27. Cudalbu C, Braissant O, Lepore M, Gruetter R, McLin VA (2012a) Brain osmolytes and brain edema in a rat model of chronic liver failure: in vivo longitudinal 1H spectroscopic imaging and diffusion tensor imaging studies at 9.4T. 15th ISHEN Symposium O7
28. Cudalbu C, Lanz B, Duarte JM, Morgenthaler FD, Pilloud Y, Mlynarik V, Gruetter R (2012b) Cerebral glutamine metabolism under hyperammonemia determined in vivo by localized (1)H and (15)N NMR spectroscopy. J Cereb Blood Flow Metab 32(4):696-708
29. Cudalbu C, Mlynarik V, Gruetter R (2012c) Handling macromolecule signals in the quantification of the neurochemical profile. J Alzheimers Dis 31:S101-S115
30. de Graaf RA, Brown PB, McIntyre S, Nixon TW, Behar KL, Rothman DL (2006) High magnetic field water and metabolite proton T1 and T2 relaxation in rat brain in vivo. Magn Reson Med 56(2):386-394
31. Desjardins P, Du T, Jiang W, Peng L, Butterworth RF (2012) Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure: role of glutamine redefined. Neurochem Int 60(7):690-696
32. Felipo V, Butterworth RF (2002) Neurobiology of ammonia. Prog Neurobiol 67(4):259-279
33. Fitzpatrick SM, Hetherington HP, Behar KL, Shulman RG (1989) Effects of acute hyperammonemia on cerebral amino acid metabolism and pHi in vivo, measured by 1H and 31P nuclear magnetic resonance. J Neurochem 52(3):741-749
34. Haussinger D, Kircheis G, Fischer R, Schliess F, vom Dahl S (2000) Hepatic encephalopathy in chronic liver disease: a clinical manifestation of astrocyte swelling and low-grade cerebral edema? J Hepatol 32(6):1035-1038
35. Kreis R, Farrow N, Ross BD (1991) Localized 1H NMR spectroscopy in patients with chronic hepatic encephalopathy. Analysis of changes in cerebral glutamine, choline and inositols. NMR Biomed 4(2):109-116
36. Kreis R, Ross BD, Farrow NA, Ackerman Z (1992) Metabolic disorders of the brain in chronic hepatic encephalopathy detected with H-1 MR spectroscopy. Radiology 182(1):19-27
37. Leke R, Bak LK, Anker M, Melo TM, Sorensen M, Keiding S, Vilstrup H, Ott P, Portela LV, Sonnewald U, Schousboe A, Waagepetersen HS (2011) Detoxification of ammonia in mouse cortical GABAergic cell cultures increases neuronal oxidative metabolism and reveals an emerging role for release of glucose-derived alanine. Neurotox Res 19(3):496-510
38. McPhail MJ, Taylor-Robinson SD (2010) The role of magnetic resonance imaging and spectroscopy in hepatic encephalopathy. Metab Brain Dis 25(1):65-72
39. Mekle R, Mlynarik V, Gambarota G, Hergt M, Krueger G, Gruetter R (2009) MR spectroscopy of the human brain with enhanced signal intensity at ultrashort echo times on a clinical platform at 3 T and 7 T. Magn Reson Med 61(6):1279-1285
40. Mlynarik V, Cudalbu C, Xin L, Gruetter R (2008a) 1H NMR spectroscopy of rat brain in vivo at 14.1Tesla: improvements in quantification of the neurochemical profile. J Magn Reson 194(2):163-168
41. Mlynarik V, Kohler I, Gambarota G, Vaslin A, Clarke PG, Gruetter R (2008b) Quantitative proton spectroscopic imaging of the neurochemical profile in rat brain with microliter resolution at ultra-short echo times. Magn Reson Med 59(1):52-58
42. Munoz SJ (2008) Hepatic encephalopathy. Med Clin North Am 92(4):795-812, viii
43. Norenberg MD (1979) Distribution of glutamine synthetase in the rat central nervous system. J Histochem Cytochem 27(3):756-762
44. Norenberg MD, Rama Rao KV, Jayakumar AR (2009) Signaling factors in the mechanism of ammonia neurotoxicity. Metab Brain Dis 24(1):103-117
45. Nyberg SL, Cerra FB, Gruetter R (1998) Brain lactate by magnetic resonance spectroscopy during fulminant hepatic failure in the dog. Liver Transpl Surg 4(2):158-165
46. Rama Rao KV, Jayakumar AR, Norenberg MD (2012) Glutamine in the pathogenesis of acute hepatic encephalopathy. Neurochem Int 61(4):575-580
47. Ross BD, Jacobson S, Villamil F, Korula J, Kreis R, Ernst T, Shonk T, Moats RA (1994) Subclinical hepatic encephalopathy: proton MR spectroscopic abnormalities. Radiology 193(2):457-463
48. Rovira A, Alonso J, Cordoba J (2008) MR imaging findings in hepatic encephalopathy. AJNR Am J Neuroradiol 29(9):1612-1621
49. Shen J, Sibson NR, Cline G, Behar KL, Rothman DL, Shulman RG (1998) 15 N-NMR spectroscopy studies of ammonia transport and glutamine synthesis in the hyperammonemic rat brain. Dev Neurosci 20(4-5):434-443
50. Spahr L, Burkhard PR, Grotzsch H, Hadengue A (2002) Clinical significance of basal ganglia alterations at brain MRI and 1H MRS in cirrhosis and role in the pathogenesis of hepatic encephalopathy. Metab Brain Dis 17(4):399-413
51. Tkac I, Gruetter R (2005) Methodology of H NMR spectroscopy of the human brain at very high magnetic fields. Appl Magn Reson 29(1):139-157
52. Tkac I, Oz G, Adriany G, Ugurbil K, Gruetter R (2009) In vivo 1H NMR spectroscopy of the human brain at high magnetic fields: metabolite quantification at 4 T vs. 7 T. Magn Reson Med 62(4):868-879
53. Urenjak J, Williams SR, Gadian DG, Noble M (1993) Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. J Neurosci 13(3):981-989
54. Williams S (1999) Cerebral amino acids studied by nuclear magnetic resonance spectroscopy in vivo. Prog Nucl Magn Reson Spectrosc 34(3-4):301-326
55. Zwingmann C (2007) The anaplerotic flux and ammonia detoxification in hepatic encephalopathy. Metab Brain Dis 22(3-4):235-249