Repeated administration of imipramine modifies GABAergic transmission in rat frontal cortex

Journal of Neural Transmission

Volumn 120, Issue 5, 2013, Pages 711-719

  Wabno, Joanna ^a   Hess, Grzegorz ^a,b  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

^b JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

GABAA receptor; Pyramidal neuron; Spontaneous IPSCs; Tricyclic antidepressant

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID A RECEPTOR BETA2; 4 AMINOBUTYRIC ACID A RECEPTOR GAMMA2; IMIPRAMINE;

4 AMINOBUTYRIC ACID RELEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; DRUG EFFECT; ELECTROPHYSIOLOGY; EX VIVO STUDY; FRONTAL CORTEX; GABAERGIC TRANSMISSION; INHIBITORY POSTSYNAPTIC POTENTIAL; MALE; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; REPEATED DRUG DOSE; SINGLE DRUG DOSE;

ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BENZHYDRYL COMPOUNDS; DRUG ADMINISTRATION SCHEDULE; EXCITATORY AMINO ACID AGONISTS; FRONTAL LOBE; GENE EXPRESSION REGULATION; IMIPRAMINE; INHIBITORY POSTSYNAPTIC POTENTIALS; MALE; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; PYRAMIDAL CELLS; RATS; RATS, WISTAR; RECEPTORS, GABA-A;

EID: 84878016211     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-012-0919-3     Document Type: Article

References (62)

1. Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS, Krystal JH (2000) Antidepressant effects of ketamine in depressed patients. Biol Psychiatry 47:351-354
2. Bleakman D, Alt A, Witkin JM (2007) AMPA receptors in the therapeutic management of depression. CNS Neurol Disord Drug Targets 6:117-126
3. Bobula B, Hess G (2008) Antidepressant treatments-induced modifications of glutamatergic transmission in rat frontal cortex. Pharmacol Rep 60:865-871
4. Bobula B, Tokarski K, Hess G (2003) Repeated administration of antidepressants decreases field potentials in rat frontal cortex. Neuroscience 120:765-769
5. Bonanno G, Giambelli R, Raiteri L, Tiraboschi E, Zappettini S, Musazzi L, Raiteri M, Racagni G, Popoli M (2005) Chronic antidepressants reduce depolarization-evoked glutamate release and protein interactions favoring formation of SNARE complex in hippocampus. J Neurosci 25:3270-3279
6. Bragina L, Melone M, Fattorini G, Conti F (2007) Clozapine upregulates the expression of the vesicular GABA transporter (VGAT) in rat frontal cortex. Mol Psychiatry 12:612-613
7. Carlson PJ, Singh JB, Zarate CA Jr, Drevets WC, Manji HK (2006) Neural circuitry and neuroplasticity in mood disorders: insights for novel therapeutic targets. NeuroRx 3:22-41
8. Choudary PV, Molnar M, Evans SJ, Tomita H, Li JZ, Vawter MP, Myers RM, Bunney WE Jr, Akil H, Watson SJ, Jones EG (2005) Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression. Proc Natl Acad Sci 102:15653-15658
9. Croarkin PE, Levinson AJ, Daskalakis ZJ (2011) Evidence for GABAergic inhibitory deficits in major depressive disorder. Neurosci Biobehav Rev 35:818-825
10. Daniel W, Adamus A, Melzacka M, Szymura J, Vetulani J (1981) Cerebral pharmacokinetics of imipramine in rats after single and multiple dosages. Naunyn-Schmiedeberg's Arch Pharmacol 317:209-213
11. Dennis T, Beauchemin V, Lavoie N (1994) Antidepressant-induced modulation of GABAA receptors and beta-adrenoceptors but not GABAB receptors in the frontal cortex of olfactory bulbectomised rats. Eur J Pharmacol 262:143-148
12. Duman RS, Voleti B (2012) Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents. Trends Neurosci 35:47-56
13. Duric V, Duman RS (2012) Depression and treatment response: dynamic interplay of signaling pathways and altered neural processes. Cell Mol Life Sci. doi: 10.1007/s00018-012-1020-7
14. Feyissa AM, Woolverton WL, Miguel-Hidalgo JJ, Wang Z, Kyle PB, Hasler G, Stockmeier CA, Iyo AH, Karolewicz B (2010) Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression. Prog Neuropsychopharmacol Biol Psychiatry 34:279-283
15. Garcia-Garcia AL, Elizalde N, Matrov D, Harro J, Wojcik SM, Venzala E, Ramírez MJ, Del Rio J, Tordera RM (2009) Increased vulnerability to depressive-like behavior of mice with decreased expression of VGLUT1. Biol Psychiatry 66:275-282
16. Gram LF (1988) Imipramine: a model substance in pharmacokinetic research. Acta Psychiatr Scand Suppl 345:81-84
17. Guidotti G, Calabrese F, Auletta F, Olivier J, Racagni G, Homberg J, Riva MA (2012) Developmental influence of the serotonin transporter on the expression of npas4 and GABAergic markers: modulation by antidepressant treatment. Neuropsychopharmacology 37:746-758
18. Hamilton SP (2011) A new lead from genetic studies in depressed siblings: assessing studies of chromosome 3. Am J Psychiatry 168:783-789
19. Hashimoto K (2011) The role of glutamate on the action of antidepressants. Prog Neuropsychopharmacol Biol Psychiatry 35:1558-1568
20. Holm MM, Nieto-Gonzalez JL, Vardya I, Henningsen K, Jayatissa MN, Wiborg O, Jensen K (2011) Hippocampal GABAergic dysfunction in a rat chronic mild stress model of depression. Hippocampus 21:422-433
21. Jenkins E, Goldner EM (2012) Approaches to understanding and addressing treatment-resistant depression: a scoping review. Depress Res Treat, doi: 10.1155/2012/469680
22. A receptor channel pharmacology. Curr Pharm Des 11:1867-1885
23. 1 subunit mRNA and protein in rat neocortex following photothrombotic infarction. Brain Res 1210:29-38
24. Lai CT, Tanay VA, Charrois GJ, Baker GB, Bateson AN (1998) Effects of phenelzine and imipramine on the steady-state levels of mRNAs that encode glutamic acid decarboxylase (GAD67 and GAD65), the GABA transporter GAT-1 and GABA transaminase in rat cortex. Naunyn Schmiedebergs Arch Pharmacol 357:32-38
25. Leung JC, Travis BR, Verlander JW, Sandhu SK, Yang SG, Zea AH, Weiner ID, Silverstein DM (2002) Expression and developmental regulation of the NMDA receptor subunits in the kidney and cardiovascular system. Am J Physiol 283:964-971
26. López-Muñoz F, Alamo C (2009) Monoaminergic neurotransmission: the history of the discovery of antidepressants from 1950s until today. Curr Pharm Des 15:1563-1586
27. A receptor trafficking, channel activity, and functional plasticity of inhibitory synapses. Pharmacol Ther 102:195-221
28. Luscher B, Shen Q, Sahir N (2011) The GABAergic deficit hypothesis of major depressive disorder. Mol Psychiatry 16:383-406
29. Maj J, Melzacka M, Mogilnicka E, Daniel W (1982) Different pharmacokinetic and pharmacological effects following acute and chronic treatment with imipramine. J Neural Transm 54:219-228
30. Makoff A, Pilling C, Harrington K, Emson P (1996) Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS. Mol Brain Res 40:165-170
31. Mathew SJ, Shah A, Lapidus K, Clark C, Jarun N, Ostermeyer B, Murrough JW (2012) Ketamine for treatment-resistant unipolar depression: current evidence. CNS Drugs 26:189-204
32. Maya Vetencourt JF, Sale A, Viegi A, Baroncelli L, De Pasquale R, O'Leary OF, Castrén E, Maffei L (2008) The antidepressant fluoxetine restores plasticity in the adult visual cortex. Science 320:385-388
33. Michael-Titus AT, Bains S, Jeetle J, Whelpton R (2000) Imipramine and phenelzine decrease glutamate overflow in the prefrontal cortex - a possible mechanism of neuroprotection in major depression? Neuroscience 100:681-684
34. 2+]c and cAMP. J Biol Chem 277:14092-14101
35. Moutsimilli L, Farley S, Dumas S, El Mestikawy S, Giros B, Tzavara ET (2005) Selective cortical VGLUT1 increase as a marker for antidepressant activity. Neuropharmacology 49:890-900
36. Murrough JW, Charney DS (2012) Is there anything really novel on the antidepressant horizon? Curr Psychiatry Rep. doi: 10.1007/s11920-012-0321-8
37. Nowak G, Trullas R, Layer RT, Skolnick P, Paul IA (1993) Adaptive changes in the N-methyl-d-aspartate receptor complex after chronic treatment with imipramine and 1-aminocyclopropanecarboxylic acid. J Pharmacol Exp Ther 265:1380-1386
38. O'Connor RM, Finger BC, Flor PJ, Cryan JF (2010) Metabotropic glutamate receptor 7: at the interface of cognition and emotion. Eur J Pharmacol 639:123-131
39. Palotás M, Palotás A, Puskás LG, Kitajka K, Pákáski M, Janka Z, Molnár J, Penke B, Kálmán J (2004) Gene expression profile analysis of the rat cortex following treatment with imipramine and citalopram. Int J Neuropsychopharmacol 7:401-413
40. Pittenger C, Sanacora G, Krystal JH (2007) The NMDA receptor as a therapeutic target in major depressive disorder. CNS Neurol Disord: Drug Targets 6:101-115
41. Potter WZ, Calil HM, Sutfin TA, Zavadil AP 3rd, Jusko WJ, Rapoport J, Goodwin FK (1982) Active metabolites of imipramine and desipramine in man. Clin Pharmacol Ther 31:393-401
42. Price RB, Shungu DC, Mao X, Nestadt P, Kelly C, Collins KA, Murrough JW, Charney DS, Mathew SJ (2009) Amino acid neurotransmitters assessed by proton magnetic resonance spectroscopy: relationship to treatment resistance in major depressive disorder. Biol Psychiatry 65:792-800
43. Sanacora G, Mason GF, Rothman DL, Behar KL, Hyder F, Petroff OA, Berman RM, Charney DS, Krystal JH (1999) Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy. Arch Gen Psychiatry 56:1043-1047
44. Sanacora G, Gueorguieva R, Epperson CN, Wu YT, Appel M, Rothman DL, Krystal JH, Mason GF (2004) Subtype-specific alterations of γ-aminobutyric acid and glutamate in patients with major depression. Arch Gen Psychiatry 61:705-713
45. Sanacora G, Treccani G, Popoli M (2012) Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders. Neuropharmacology 62:63-77
46. Schloss P, Williams DC (1998) The serotonin transporter: a primary target for antidepressant drugs. J Psychopharmacol 12:115-121
47. Shen Q, Lal R, Luellen BA, Earnheart JC, Andrews AM, Luscher B (2010) Gamma-aminobutyric acid - type A receptor deficits cause hypothalamic-pituitary- adrenal axis hyperactivity and antidepressant drug sensitivity reminiscent of melancholic forms of depression. Biol Psychiatry 68:512-520
48. A receptors. J Neurochem 112:1115-1130
49. Skolnick P, Popik P, Trullas R (2009) Glutamate-based antidepressants: 20 years on. Trends Phamacol Sci 30:563-569
50. Slattery DA, Hudson AL, Nutt DJ (2004) Invited review: the evolution of antidepressant mechanisms. Fundam Clin Pharmacol 18:1-21
51. Sukoff Rizzo SJ, Leonard SK, Gilbert A, Dollings P, Smith DL, Zhang MY, Di L, Platt BJ, Neal S, Dwyer JM, Bender CM, Zhang J, Lock T, Kowal D, Kramer A, Randall A, Huselton C, Vishwanathan K, Tse SY, Butera J, Ring RH, Rosenzweig-Lipson S, Hughes ZA, Dunlop J (2011) The mGluR7 allosteric modulator AMN082: a monoaminergic agent in disguise? J Pharm Exp Ther 338:345-352
52. Summa M, Di Prisco S, Grilli M, Usai C, Marchi M, Pittaluga A (2012) Presynaptic mGlu7 receptors control GABA release in mouse hippocampus. Neuropharmacology (Epub ahead of print)
53. A receptor subunit gene expression. Mol Psychiatry 6:404-412
54. Tokarski K, Urban-Ciecko J, Kossut M, Hess G (2007) Sensory learning-induced enhancement of inhibitory synaptic transmission in the barrel cortex of the mouse. Eur J Neurosci 26:134-141
55. Tokarski K, Bobula B, Wabno J, Hess G (2008) Repeated administration of imipramine attenuates glutamatergic transmission in rat frontal cortex. Neuroscience 153:789-795
56. Tunnicliff G, Malatynska E (2003) Central GABAergic system and depressive illness. Neurochem Res 28:965-976
57. Venzala E, García-García AL, Elizalde N, Tordera RM (2012) Social vs. environmental stress models of depression from a behavioural and neurochemical approach. Eur Neuropsychopharmacol. http://dx.doi.org/10.1016/j. euroneuro.2012.05.010
58. Wierońska JM, Kłak K, Pałucha A, Brański P, Pilc A (2007) Citalopram influences mGlu7, but not mGlu4 receptors' expression in the rat brain hippocampus and cortex. Brain Res 1184:88-95
59. 4 receptor activation in the CA1 area of rat hippocampus. Eur Neuropsychopharmacol 16:383-390
60. Zarate C Jr, Machado-Vieira R, Henter I, Ibrahim L, Diazgranados N, Salvadore G (2010) Glutamatergic modulators: the future of treating mood disorders? Harv Rev Psychiatry 18:293-303
61. Zhong P, Yan Z (2004) Chronic antidepressant treatment alters serotonergic regulation of GABA transmission in prefrontal cortical pyramidal neurons. Neuroscience 129:65-73
62. Zink M, Vollmayr B, Gebicke-Haerter PJ, Henn FA (2010) Reduced expression of glutamate transporters vGluT1, EAAT2 and EAAT4 in learned helpless rats, an animal model of depression. Neuropharmacology 58:465-473