Mammalian glutaminase isozymes in brain

Metabolic Brain Disease

Volumn 28, Issue 2, 2013, Pages 133-137

  Márquez, Javier ^a   Cardona, Carolina ^a   Campos Sandoval, José A ^a   Peñalver, Ana ^a   Tosina, Marta ^a   Matés, José M ^a   Martín Rufián, Mercedes ^a  

^a UNIVERSITY OF MÁLAGA   (Spain)

Author keywords

Astrocytes; Hepatic encephalopathy; Mammalian glutaminases; Multifunctional proteins; Novel isoforms; Protein trafficking

Indexed keywords

AMMONIA; GLUTAMIC ACID; GLUTAMINASE; GLUTAMINASE ISOZYME; ISOENZYME; PDZ PROTEIN; UNCLASSIFIED DRUG; NERVE PROTEIN;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ASTROCYTE; BRAIN METABOLISM; CONFERENCE PAPER; DEGENERATIVE DISEASE; ENZYME ACTIVITY; ENZYME REGULATION; GENE EXPRESSION; GLIA CELL; HEPATIC ENCEPHALOPATHY; HUMAN; MAMMAL CELL; METABOLIC REGULATION; MITOCHONDRIAL PERMEABILITY; NERVOUS TISSUE; NEUROTRANSMISSION; NONHUMAN; OSMOTIC STRESS; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TRINUCLEOTIDE REPEAT; ANIMAL; BRAIN; BRAIN LEVEL; ENZYMOLOGY; GENETICS; METABOLISM;

MAMMALIA;

ANIMALS; ASTROCYTES; BRAIN; BRAIN CHEMISTRY; GLUTAMINASE; HEPATIC ENCEPHALOPATHY; HUMANS; ISOENZYMES; NERVE TISSUE PROTEINS;

EID: 84878015174     PISSN: 08857490     EISSN: 15737365     Source Type: Journal    
DOI: 10.1007/s11011-012-9356-0     Document Type: Conference Paper

References (27)

1. Albrecht J, Norenberg MD (2006) Glutamine: a Trojan horse in ammonia neurotoxicity. Hepatology 44:788-794
2. Aledo JC, Gómez-Fabre PM, Olalla L, Márquez J (2000) Identification of two human glutaminase loci and tissue-specific expression of the two related genes. Mammal Genome 11:1107-1110
3. Baverel G, Michoudet C, Martin G (1984) Role of fatty acids in simultaneaus regulation of flux through glutaminase and glutamine synthetase in rat kidney cortex. In: Häussinger D, Sies H (eds) Glutamine metabolism in mammalian tissues. Springer, Berlin, pp 187-202
4. Bragg AD, Amiry-Moghaddam M, Ottersen OP et al (2006) Assembly of a perivascular astrocyte protein scaffold at the mammalian blood-brain barrier is dependent on alpha-syntrophin. Glia 53:879-890
5. Buschdorf JP, Chew LL, Zhang B et al (2006) Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels. J Cell Sci 119:3337-3350
6. Elgadi KM, Meguid RA, Qian M et al (1999) Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing. Physiol Genomics 1:51-62
7. Häussinger D, Gerok W, Sies H (1982) Regulation of flux through glutaminase and glutamine synthetase in isolated perfused rat liver. Biochim Biophys Acta 755:272-278
8. Häussinger D, Kircheis G, Fischer R, Schliess F, vom Dahl S (2000) Hepatic encephalopathy in chronic liver disease: a clinical manifestation of astrocyte swelling and low grade cerebral edema. J Hepatol 32:1035-1038
9. Hertz L (1979) Functional interactions between neurons and astrocytes I. Turnover and metabolism of putative amino acid transmitters. Prog Neurobiol 13:277-323
10. Kvamme E, Svenneby G, Hertz L, Schousboe A (1982) Properties of phosphate activated glutaminase in astrocytes cultured from mouse brain. Neurochem Res 7:761-770
11. Márquez J, Sánchez-Jiménez F, Medina MA et al (1989) Nitrogen metabolism in tumor bearing mice. Arch Biochem Biophys 268:667-675
12. Márquez J, López de la Oliva AR, Matés JM et al (2006) Glutaminase: a multifaceted protein not only involved in generating glutamate. Neurochem Int 48:465-71
13. Márquez J, Matés JM, Segura JA et al (2010) Brain glutaminases. Biomol Concepts 1:3-15
14. Martín-Rufián M, Tosina M, Campos-Sandoval JA et al (2012) Mammalian glutaminase Gls2 gene encodes two functional alternative transcripts by a surrogate promoter usage mechanism. PLoS One 7:e38380. Epub 2012 Jun 5. PMID: 22679499
15. Norenberg MD, Martínez-Hernández A (1979) Fine structural localization of glutamine synthetase in astrocytes of rat brain. Brain Res 161:303-310
16. Olalla L, Aledo JC, Bannenberg G, Márquez J (2001) The C-terminus of human glutaminase L mediates association with PDZ domain-containing proteins. FEBS Lett 488:116-122
17. Olalla L, Gutiérrez A, Campos JA et al (2002) Nuclear localization of L-glutaminase in mammalian brain. J Biol Chem 277:38939-38944
18. Olalla L, Gutiérrez A, Jiménez AJ et al (2008) Expression of scaffolding PDZ protein GIP (Glutaminase-Interacting-Protein) in mammalian brain. J Neurosci Res 86:281-292
19. Olde Damink SW, Jalan R, Redhead DN, Hayes PC et al (2002) Interorgan ammonia and amino acid metabolism in metabolically stable patients with cirrhosis and a TIPPS. Hepatology 36:1163-1171
20. Quesada AR, Medina MA, Márquez J et al (1988) Contribution by host tissues to circulating glutamine in mice inoculated with Ehrlich ascites tumor cells. Cancer Res 48:1551-1553
21. Rama Rao KV, Jayakumar AR, Norenberg MD (2005) Differential response of glutamine in cultured neurons and astrocytes. J Neurosci Res 79:193-199
22. Romero-Gómez M, Ramos-Guerrero R, Grande L, de Terán LC et al (2004) Intestinal glutaminase activity is increased in liver cirrhosis and correlates with minimal hepatic encephalopathy. J Hepatol 41:49-54
23. Romero-Gómez M, Jover M, Del Campo JA, Royo JL et al (2010) Variations in the promoter region of the glutaminase gene and the development of hepatic encephalopathy in patients with cirrhosis. Ann Intern Med 153:281-288
24. Szeliga M, Matyja E, Obara M et al (2008) Relative expression of mRNAs coding for glutaminase isoforms in CNS tissues and CNS tumors. Neurochem Res 33:808-813
25. Szeliga M, Obara-Michlewska M, Matyja E et al (2009) Transfection with liver-type glutaminase (LGA) cDNA alteres gene expression and reduces viability, migration and proliferation of T98G glioma cells. Glia 57:1014-1023
26. Thangavelu K, Pan CQ, Karlberg T et al (2012) Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism. Proc Natl Acad Sci USA 109:7705-7710
27. Wang JB, Erickson JW, Fuji R et al (2010) Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell 18:207-219