Behavioral effects of the novel potent cannabinoid CB1 agonist AM 4054

Pharmacology Biochemistry and Behavior

Volumn 109, Issue , 2013, Pages 16-22

  McLaughlin, Peter J ^a,c   Thakur, Ganesh A ^b   Vemuri, V Kiran ^b   McClure, Evan D ^a   Brown, Cara M ^a   Winston, Keisha M ^a   Wood, Jodianne T ^b   Makriyannis, Alexandros ^b   Salamone, John D ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b NORTHEASTERN UNIVERSITY   (United States)

^c EDINBORO UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cannabinoid; Microanalysis; Motor control; Operant

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; AM 4054; CANNABINOID 1 RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; BEHAVIOR CHANGE; CATALEPSY; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG RECEPTOR BINDING; HYPOTHERMIA; INSTRUMENTAL CONDITIONING; LOCOMOTION; MALE; NONHUMAN; OPEN FIELD BEHAVIOR; PRIORITY JOURNAL; RAT; TASK PERFORMANCE;

ADAMANTANE; ANIMALS; BEHAVIOR, ANIMAL; CANNABINOL; CONDITIONING, OPERANT; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB1;

RATTUS;

EID: 84878008481     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2013.04.011     Document Type: Article

References (40)

1. J.M. Adam, J.K. Clark, and K. Davies Low brain penetrant CB1 receptor agonists for the treatment of neuropathic pain Bioorg Med Chem Lett 22 2012 2932 2937
2. A. Arevalo-Martin, E. Molina-Holgado, and C. Guaza A CB1/CB2 receptor agonist, WIN 55,212-2, exerts its therapeutic effect in a viral autoimmune model of multiple sclerosis by restoring self-tolerance to myelin Neuropharmacology 63 2012 385 393
3. J. Bergman, M.S. Delatte, C.A. Paronis, K. Vemuri, G.A. Thakur, and A. Makriyannis Some effects of CB1 antagonists with inverse agonist and neutral biochemical properties Physiol Behav 93 2008 666 670 (Pubitemid 351381065)
4. D. Carriero, J. Aberman, S.Y. Lin, A. Hill, A. Makriyannis, and J.D. Salamone A detailed characterization of the effects of four cannabinoid agonists on operant lever pressing Psychopharmacology (Berl) 137 1998 147 156 (Pubitemid 28227332)
5. Alvares L. de Oliveira, B.P. Genro, F. Diehl, and J.A. Quillfeldt Differential role of the hippocampal endocannabinoid system in the memory consolidation and retrieval mechanisms Neurobiol Learn Mem 90 2008 1 9
6. J. De Vry, and K.R. Jentzsch Partial agonist-like profile of the cannabinoid receptor antagonist SR141716A in a food-reinforced operant paradigm Behav Pharmacol 15 2004 13 20 (Pubitemid 38241509)
7. R.I. Desai, G.A. Thakur, K. Vemuri, S. Bajaj, A. Makriyannis, and J. Bergman Analysis of tolerance and behavioral/physical dependence during chronic CB1 agonist treatment: effects of CB1 agonists, antagonists, and non-cannabinoid drugs J Pharmacol Exp Ther 344 2013 319 328
8. W.A. Devane, A. Breuer, T. Sheskin, T.U. Järbe, M.S. Eisen, and R. Mechoulam A novel probe for the cannabinoid receptor J Med Chem 35 1992 2065 2069
9. M. Egertová, and M.R. Elphick Localisation of cannabinoid receptors in the rat brain using antibodies to the intracellular C-terminal tail of CB1 J Comp Neurol 422 2000 159 171 (Pubitemid 30390161)
10. F. Ferrari, A. Ottani, R. Vivoli, and D. Giuliani Learning impairment produced in rats by the cannabinoid agonist HU 210 in a water-maze task Pharmacol Biochem Behav 64 1999 555 561 (Pubitemid 29488485)
11. 123I-labeled AM 251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors Eur J Pharmacol 307 1996 331 338 (Pubitemid 26233375)
12. D. Giuliani, A. Ottani, and F. Ferrari Effects of the cannabinoid receptor agonist, HU 210, on ingestive behaviour and body weight of rats Eur J Pharmacol 391 2000 275 279 (Pubitemid 30154095)
13. M. Herkenham, A. Lynn, M.R. Johnson, L.S. Melvin, B.R. de Costa, and K.C. Rice Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study J Neurosci 11 1991 563 583
14. A.C. Howlett, F. Barth, and T.I. Bonner International union of pharmacology. XXVII. Classification of cannabinoid receptors Pharmacol Rev 54 2002 161 202 (Pubitemid 34575709)
15. Institute of Laboratory Animal Resources Guide for the care and use of laboratory animals 8th Ed. 2011 National Academy Press Washington DC
16. A.A. Izzo, and A.A. Coutts Cannabinoids and the digestive tract Handb Exp Pharmacol 168 2005 573 598
17. 9-THC and the CB1 receptor antagonist SR-141716 in rats: open-field revisited Pharmacol Biochem Behav 73 2002 911 919 (Pubitemid 35246241)
18. T.U. Järbe, R.J. Lamb, Q. Liu, and A. Makriyannis (R)-Methanandamide and delta9-tetrahydrocannabinol-induced operant rate decreases in rats are not readily antagonized by SR-141716A Eur J Pharmacol 466 2003 121 127 (Pubitemid 36385097)
19. T.U. Järbe, N.V. DiPatrizio, D. Lu, and A. Makriyannis (-)-Adamantyl-delta-8-tetrahydrocannabinol (AM-411), a selective cannabinoid CB1 receptor agonist: effects on open-field behaviors and antagonism by SR-141716 in rats Behav Pharmacol 15 2004 517 521 (Pubitemid 39482941)
20. M.R. Johnson, and L.S. Melvin The discovery of nonclassical cannabinoid analgetics R. Mechoulam, Cannabinoids as therapeutic agents 1986 CRC Press, Inc. Boca Raton, FL 121 145
21. B.D. Kangas, M.S. Delatte, V.K. Vemuri, G.A. Thakur, S.P. Nikas, and K.V. Subramanian Cannabinoid discrimination and antagonism by CB1 neutral and inverse agonist antagonists J Pharmacol Exp Ther 344 2013 561 567
22. G. Keppel, and T.D. Wickens Design and analysis: a researcher's handbook 4th Ed. 2004 Pearson Prentice Hall Upper Saddle River, NJ
23. R.S. Landsman, T.H. Burkey, P. Consroe, W.R. Roeske, and H.I. Yamamura SR141716A is an inverse agonist at the human cannabinoid CB1 receptor Eur J Pharmacol 334 1997 R1 R2
24. B.R. Martin, D.R. Compton, B.F. Thomas, W.R. Prescott, P.J. Little, and R.K. Razdan Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs Pharmacol Biochem Behav 40 1991 471 478
25. P.J. McLaughlin, C.M. Brown, K.M. Winston, G.A. Thakur, D. Lu, and A. Makriyannis The novel cannabinoid agonist AM 411 produces a biphasic effect on accuracy in a visual target detection task in rats Behav Pharmacol 16 2005 477 486 (Pubitemid 41404821)
26. P.J. McLaughlin, D. Lu, K.W. Winston, G.A. Thakur, L.A. Swezey, and A. Makriyannis Behavioral effects of the novel cannabinoid full agonist AM 411 Pharmacol Biochem Behav 81 2005 78 88 (Pubitemid 40718955)
27. P.J. McLaughlin, L. Qian, J.T. Wood, A. Wisniecki, K.M. Winston, and L.A. Swezey Suppression of food intake and food-reinforced behavior produced by the novel CB1 receptor antagonist/inverse agonist AM1387 Pharmacol Biochem Behav 83 2006 396 402 (Pubitemid 43736963)
28. P.J. McLaughlin, K.M. Winston, L.A. Swezey, A. Makriyannis, and J.D. Salamone Detailed analysis of food-reinforced operant lever pressing distinguishes effects of antagonism of cannabinoid CB1 and dopamine D1 and D2 receptors Pharmacol Biochem Behav 96 2010 75 81
29. K.R. Müller-Vahl Cannabinoids reduce symptoms of Tourette's syndrome Expert Opin Pharmacother 4 2003 1717 1725 (Pubitemid 37322357)
30. A. Ottani, F. Ferrari, and D. Giuliani Neuroleptic-like profile of the cannabinoid agonist, HU 210, on rodent behavioral models Prog Neuropsychopharmacol Biol Psychiatry 26 2002 91 96 (Pubitemid 34045152)
31. C.A. Paronis, G.A. Thakur, S. Bajaj, S.P. Nikas, V.K. Vemuri, and A. Makriyannis Diuretic effects of cannabinoids J Pharmacol Exp Ther 344 2013 8 14
32. R. Pedroza-Llinás, M. Méndez-Díaz, A.E. Ruiz-Contreras, and O. Prospéro-García CB1 receptor activation in the nucleus accumbens core impairs contextual fear learning Behav Brain Res 237 2013 141 147
33. R.G. Pertwee Pharmacological actions of cannabinoids Handb Exp Pharmacol 168 2005 1 51
34. R.G. Pertwee Inverse agonism and neutral antagonism at cannabinoid CB1 receptors Life Sci 76 2005 1307 1324
35. L. Prut, and C. Belzung The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review Eur J Pharmacol 463 2003 3 33 (Pubitemid 36205070)
36. A.A. Rey, M. Purrio, M.P. Viveros, and B. Lutz Biphasic effects of cannabinoids in anxiety responses: CB1 and GABA(B) receptors in the balance of gabaergic and glutamatergic neurotransmission Neuropsychopharmacology 37 2012 2624 2634
37. M. Rinaldi-Carmona, and F. Barth SR 141716A, a potent and selective antagonist of the brain cannabinoid receptor FEBS Lett 350 1994 240 244 (Pubitemid 24268029)
38. T. Wenger, C. Ledent, V. Csernus, and I. Gerendai The central cannabinoid receptor inactivation suppresses endocrine reproductive functions Biochem Biophys Res Commun 284 2001 363 368 (Pubitemid 32917985)
39. J.L. Wiley, and B.R. Martin Cannabinoid pharmacological properties common to other centrally acting drugs Eur J Pharmacol 471 2003 185 193 (Pubitemid 36776413)
40. C.M. Williams, and T.C. Kirkham Observational analysis of feeding induced by Δ9-THC and anandamide Physiol Behav 76 2002 241 250 (Pubitemid 34607232)