메뉴 건너뛰기




Volumn 1, Issue 1, 2013, Pages 1-8

Alpha-linolenic acid: A promising nutraceutical for the prevention of stroke

Author keywords

Alpha linolenic acid; Enriched diet; Ischemic stroke; Neuroprotection; Nutraceutical; Omega 3 polyunsaturated fatty acid

Indexed keywords

DOCOSAPENTAENOIC ACID; ICOSAPENTAENOIC ACID; LINOLENIC ACID; NUTRACEUTICAL; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; RILUZOLE; VEGETABLE OIL;

EID: 84878001704     PISSN: 22134344     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phanu.2012.12.002     Document Type: Review
Times cited : (49)

References (56)
  • 1
    • 0034093231 scopus 로고    scopus 로고
    • The global burden of disease study: implications for neurology
    • Menken M., Munsat T.L., Toole J.F. The global burden of disease study: implications for neurology. Archives of Neurology 2000, 57:418-420.
    • (2000) Archives of Neurology , vol.57 , pp. 418-420
    • Menken, M.1    Munsat, T.L.2    Toole, J.F.3
  • 2
    • 77649126524 scopus 로고    scopus 로고
    • Heart disease and stroke statistics - 2010 update: a report from the American heart association
    • Lloyd-Jones D., Adams R.J., Brown T.M., Carnethon M., Dai S., De Simone G., et al. Heart disease and stroke statistics - 2010 update: a report from the American heart association. Circulation 2010, 121:e46-e215.
    • (2010) Circulation , vol.121
    • Lloyd-Jones, D.1    Adams, R.J.2    Brown, T.M.3    Carnethon, M.4    Dai, S.5    De Simone, G.6
  • 3
    • 39749191084 scopus 로고    scopus 로고
    • Heart disease and stroke statistics - 2008 update: a report from the American heart association statistics committee and stroke statistics subcommittee
    • Rosamond W., Flegal K., Furie K., Go A., Greenlund K., Haase N., et al. Heart disease and stroke statistics - 2008 update: a report from the American heart association statistics committee and stroke statistics subcommittee. Circulation 2008, 117:e25-e146.
    • (2008) Circulation , vol.117
    • Rosamond, W.1    Flegal, K.2    Furie, K.3    Go, A.4    Greenlund, K.5    Haase, N.6
  • 4
    • 0034643939 scopus 로고    scopus 로고
    • Frequency of stroke in Europe: a collaborative study of population-based cohorts. Ilsa working group and the neurologic diseases in the elderly research group. Italian longitudinal study on aging
    • Di Carlo A., Launer L.J., Breteler M.M., Fratiglioni L., Lobo A., Martinez-Lage J., et al. Frequency of stroke in Europe: a collaborative study of population-based cohorts. Ilsa working group and the neurologic diseases in the elderly research group. Italian longitudinal study on aging. Neurology 2000, 54:S28-S33.
    • (2000) Neurology , vol.54
    • Di Carlo, A.1    Launer, L.J.2    Breteler, M.M.3    Fratiglioni, L.4    Lobo, A.5    Martinez-Lage, J.6
  • 5
    • 1942499593 scopus 로고    scopus 로고
    • Costs of stroke care according to handicap levels and stroke subtypes
    • Spieler J.F., Lanoe J.L., Amarenco P. Costs of stroke care according to handicap levels and stroke subtypes. Cerebrovascular Diseases 2004, 17:134-142.
    • (2004) Cerebrovascular Diseases , vol.17 , pp. 134-142
    • Spieler, J.F.1    Lanoe, J.L.2    Amarenco, P.3
  • 9
    • 77955487488 scopus 로고    scopus 로고
    • The science of stroke: mechanisms in search of treatments
    • Moskowitz M.A., Lo E.H., Iadecola C. The science of stroke: mechanisms in search of treatments. Neuron 2010, 67:181-198.
    • (2010) Neuron , vol.67 , pp. 181-198
    • Moskowitz, M.A.1    Lo, E.H.2    Iadecola, C.3
  • 11
    • 40349093039 scopus 로고    scopus 로고
    • Pathophysiology of ischaemic stroke: insights from imaging, and implications for therapy and drug discovery
    • Moustafa R.R., Baron J.C. Pathophysiology of ischaemic stroke: insights from imaging, and implications for therapy and drug discovery. British Journal of Pharmacology 2008, 153(Suppl. 1):S44-S54.
    • (2008) British Journal of Pharmacology , vol.153 , Issue.SUPPL. 1
    • Moustafa, R.R.1    Baron, J.C.2
  • 13
    • 84872667183 scopus 로고    scopus 로고
    • Risk factor burden predicts long-term mortality in young patients with arterial cerebral infarction
    • John Wiley & Sons A/S
    • Naess H., Waje-Andreassen U., Nyland H. Risk factor burden predicts long-term mortality in young patients with arterial cerebral infarction. Acta Neurologica Scandinavica 2012, John Wiley & Sons A/S. 10.1111/j.1600-0404.2012.01681.x.
    • (2012) Acta Neurologica Scandinavica
    • Naess, H.1    Waje-Andreassen, U.2    Nyland, H.3
  • 15
    • 84969641882 scopus 로고    scopus 로고
    • A new future in brain preconditioning based on nutraceuticals: a focus on a-linolenic omega-3 fatty acid for stroke protection
    • Springer, New York, J.M. Gidday, M.A. Perez-Pinzon, J.H. Zhang (Eds.)
    • Blondeau N., Tauskela J.S. A new future in brain preconditioning based on nutraceuticals: a focus on a-linolenic omega-3 fatty acid for stroke protection. Innate tolerance in the CNS 2013, 133-163. Springer, New York. J.M. Gidday, M.A. Perez-Pinzon, J.H. Zhang (Eds.).
    • (2013) Innate tolerance in the CNS , pp. 133-163
    • Blondeau, N.1    Tauskela, J.S.2
  • 16
    • 0029090398 scopus 로고
    • Who and fao joint consultation: fats and oils in human nutrition
    • World Health Organization
    • World Health Organization Who and fao joint consultation: fats and oils in human nutrition. Nutrition Reviews 1995, 53:202-205.
    • (1995) Nutrition Reviews , vol.53 , pp. 202-205
  • 17
    • 0001252858 scopus 로고
    • Nutritional and metabolic interrelationships between fatty acids
    • Holman R.T. Nutritional and metabolic interrelationships between fatty acids. Federation Proceedings 1964, 23:1062-1067.
    • (1964) Federation Proceedings , vol.23 , pp. 1062-1067
    • Holman, R.T.1
  • 19
    • 0028068555 scopus 로고
    • Dietary linoleic acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males
    • Emken E.A., Adlof R.O., Gulley R.M. Dietary linoleic acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males. Biochimica et Biophysica Acta 1994, 1213:277-288.
    • (1994) Biochimica et Biophysica Acta , vol.1213 , pp. 277-288
    • Emken, E.A.1    Adlof, R.O.2    Gulley, R.M.3
  • 20
    • 36649009728 scopus 로고    scopus 로고
    • UK food standards agency workshop report: the effects of the dietary n-6:N-3 fatty acid ratio on cardiovascular health
    • Stanley J.C., Elsom R.L., Calder P.C., Griffin B.A., Harris W.S., Jebb S.A., et al. UK food standards agency workshop report: the effects of the dietary n-6:N-3 fatty acid ratio on cardiovascular health. British Journal of Nutrition 2007, 98:1305-1310.
    • (2007) British Journal of Nutrition , vol.98 , pp. 1305-1310
    • Stanley, J.C.1    Elsom, R.L.2    Calder, P.C.3    Griffin, B.A.4    Harris, W.S.5    Jebb, S.A.6
  • 22
    • 79952237035 scopus 로고    scopus 로고
    • Food sources and intake of n-6 and n-3 fatty acids in low-income countries with emphasis on infants, young children (6-24 months), and pregnant and lactating women
    • Michaelsen K.F., Dewey K.G., Perez-Exposito A.B., Nurhasan M., Lauritzen L., Roos N. Food sources and intake of n-6 and n-3 fatty acids in low-income countries with emphasis on infants, young children (6-24 months), and pregnant and lactating women. Maternal & Child Nutrition 2011, 7(Suppl. 2):124-140.
    • (2011) Maternal & Child Nutrition , vol.7 , Issue.SUPPL. 2 , pp. 124-140
    • Michaelsen, K.F.1    Dewey, K.G.2    Perez-Exposito, A.B.3    Nurhasan, M.4    Lauritzen, L.5    Roos, N.6
  • 23
    • 0346039322 scopus 로고    scopus 로고
    • Nutraceutical - definition and introduction
    • Kalra E.K. Nutraceutical - definition and introduction. AAPS PharmSci 2003, 5:E25.
    • (2003) AAPS PharmSci , vol.5
    • Kalra, E.K.1
  • 24
    • 13944270939 scopus 로고    scopus 로고
    • Long-chain conversion of [13c]linoleic acid and alpha-linolenic acid in response to marked changes in their dietary intake in men
    • Hussein N., Ah-Sing E., Wilkinson P., Leach C., Griffin B.A., Millward D.J. Long-chain conversion of [13c]linoleic acid and alpha-linolenic acid in response to marked changes in their dietary intake in men. Journal of Lipid Research 2005, 46:269-280.
    • (2005) Journal of Lipid Research , vol.46 , pp. 269-280
    • Hussein, N.1    Ah-Sing, E.2    Wilkinson, P.3    Leach, C.4    Griffin, B.A.5    Millward, D.J.6
  • 25
    • 0034884757 scopus 로고    scopus 로고
    • Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans
    • Pawlosky R.J., Hibbeln J.R., Novotny J.A., Salem N. Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans. Journal of Lipid Research 2001, 42:1257-1265.
    • (2001) Journal of Lipid Research , vol.42 , pp. 1257-1265
    • Pawlosky, R.J.1    Hibbeln, J.R.2    Novotny, J.A.3    Salem, N.4
  • 26
    • 70350059182 scopus 로고    scopus 로고
    • Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: benefits for human health and a role in maintaining tissue n-3 fatty acid levels
    • Barcelo-Coblijn G., Murphy E.J. Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: benefits for human health and a role in maintaining tissue n-3 fatty acid levels. Progress in Lipid Research 2009, 48:355-374.
    • (2009) Progress in Lipid Research , vol.48 , pp. 355-374
    • Barcelo-Coblijn, G.1    Murphy, E.J.2
  • 27
    • 33746085077 scopus 로고    scopus 로고
    • Dietary alpha-linolenic acid and health-related outcomes: a metabolic perspective
    • Burdge G.C., Calder P.C. Dietary alpha-linolenic acid and health-related outcomes: a metabolic perspective. Nutrition Research Reviews 2006, 19:26-52.
    • (2006) Nutrition Research Reviews , vol.19 , pp. 26-52
    • Burdge, G.C.1    Calder, P.C.2
  • 28
    • 33747120160 scopus 로고    scopus 로고
    • N-3 fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review
    • Wang C., Harris W.S., Chung M., Lichtenstein A.H., Balk E.M., Kupelnick B., et al. N-3 fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review. American Journal of Clinical Nutrition 2006, 84:5-17.
    • (2006) American Journal of Clinical Nutrition , vol.84 , pp. 5-17
    • Wang, C.1    Harris, W.S.2    Chung, M.3    Lichtenstein, A.H.4    Balk, E.M.5    Kupelnick, B.6
  • 29
    • 0020010537 scopus 로고
    • Dietary requirements and functions of alpha-linolenic acid in animals
    • Tinoco J. Dietary requirements and functions of alpha-linolenic acid in animals. Progress in Lipid Research 1982, 21:1-45.
    • (1982) Progress in Lipid Research , vol.21 , pp. 1-45
    • Tinoco, J.1
  • 30
    • 33646844063 scopus 로고    scopus 로고
    • Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat
    • King V.R., Huang W.L., Dyall S.C., Curran O.E., Priestley J.V., Michael-Titus A.T. Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat. Journal of Neuroscience 2006, 26:4672-4680.
    • (2006) Journal of Neuroscience , vol.26 , pp. 4672-4680
    • King, V.R.1    Huang, W.L.2    Dyall, S.C.3    Curran, O.E.4    Priestley, J.V.5    Michael-Titus, A.T.6
  • 33
    • 0037185379 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids induce ischemic and epileptic tolerance
    • Blondeau N., Widmann C., Lazdunski M., Heurteaux C. Polyunsaturated fatty acids induce ischemic and epileptic tolerance. Neuroscience 2002, 109:231-241.
    • (2002) Neuroscience , vol.109 , pp. 231-241
    • Blondeau, N.1    Widmann, C.2    Lazdunski, M.3    Heurteaux, C.4
  • 35
    • 70350066366 scopus 로고    scopus 로고
    • Subchronic alpha-linolenic acid treatment enhances brain plasticity and exerts an antidepressant effect: a versatile potential therapy for stroke
    • Blondeau N., Nguemeni C., Debruyne D.N., Piens M., Wu X., Pan H., et al. Subchronic alpha-linolenic acid treatment enhances brain plasticity and exerts an antidepressant effect: a versatile potential therapy for stroke. Neuropsychopharmacology 2009, 34:2548-2559.
    • (2009) Neuropsychopharmacology , vol.34 , pp. 2548-2559
    • Blondeau, N.1    Nguemeni, C.2    Debruyne, D.N.3    Piens, M.4    Wu, X.5    Pan, H.6
  • 36
    • 0242269459 scopus 로고    scopus 로고
    • Anticonvulsant efficiency, behavioral performance and cortisol levels: a comparison of carbamazepine (cbz) and a fatty acid compound (sr-3)
    • Rabinovitz S., Mostofsky D.I., Yehuda S. Anticonvulsant efficiency, behavioral performance and cortisol levels: a comparison of carbamazepine (cbz) and a fatty acid compound (sr-3). Psychoneuroendocrinology 2004, 29:113-124.
    • (2004) Psychoneuroendocrinology , vol.29 , pp. 113-124
    • Rabinovitz, S.1    Mostofsky, D.I.2    Yehuda, S.3
  • 37
    • 46449123205 scopus 로고    scopus 로고
    • The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases
    • Simopoulos A.P. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Experimental Biology and Medicine (Maywood, NJ) 2008, 233:674-688.
    • (2008) Experimental Biology and Medicine (Maywood, NJ) , vol.233 , pp. 674-688
    • Simopoulos, A.P.1
  • 38
    • 0642337765 scopus 로고    scopus 로고
    • Dietary linolenic acid is inversely associated with plasma triacylglycerol: the national heart, lung, and blood institute family heart study
    • Djousse L., Hunt S.C., Arnett D.K., Province M.A., Eckfeldt J.H., Ellison R.C. Dietary linolenic acid is inversely associated with plasma triacylglycerol: the national heart, lung, and blood institute family heart study. American Journal of Clinical Nutrition 2003, 78:1098-1102.
    • (2003) American Journal of Clinical Nutrition , vol.78 , pp. 1098-1102
    • Djousse, L.1    Hunt, S.C.2    Arnett, D.K.3    Province, M.A.4    Eckfeldt, J.H.5    Ellison, R.C.6
  • 40
    • 3342981356 scopus 로고    scopus 로고
    • Trek-1, a k+ channel involved in neuroprotection and general anesthesia
    • Heurteaux C., Guy N., Laigle C., Blondeau N., Duprat F., Mazzuca M., et al. Trek-1, a k+ channel involved in neuroprotection and general anesthesia. EMBO Journal 2004, 23:2684-2695.
    • (2004) EMBO Journal , vol.23 , pp. 2684-2695
    • Heurteaux, C.1    Guy, N.2    Laigle, C.3    Blondeau, N.4    Duprat, F.5    Mazzuca, M.6
  • 42
    • 34047127530 scopus 로고    scopus 로고
    • Altered acetylcholine, bradykinin and cutaneous pressure-induced vasodilation in mice lacking the trek1 potassium channel: the endothelial link
    • Garry A., Fromy B., Blondeau N., Henrion D., Brau F., Gounon P., et al. Altered acetylcholine, bradykinin and cutaneous pressure-induced vasodilation in mice lacking the trek1 potassium channel: the endothelial link. EMBO Reports 2007, 8:354-359.
    • (2007) EMBO Reports , vol.8 , pp. 354-359
    • Garry, A.1    Fromy, B.2    Blondeau, N.3    Henrion, D.4    Brau, F.5    Gounon, P.6
  • 43
    • 0024202945 scopus 로고
    • Effect of dietary alpha-linolenate/linoleate balance on mean survival time, incidence of stroke and blood pressure of spontaneously hypertensive rats
    • Shimokawa T., Moriuchi A., Hori T., Saito M., Naito Y., Kabasawa H., et al. Effect of dietary alpha-linolenate/linoleate balance on mean survival time, incidence of stroke and blood pressure of spontaneously hypertensive rats. Life Sciences 1988, 43:2067-2075.
    • (1988) Life Sciences , vol.43 , pp. 2067-2075
    • Shimokawa, T.1    Moriuchi, A.2    Hori, T.3    Saito, M.4    Naito, Y.5    Kabasawa, H.6
  • 44
    • 29744459904 scopus 로고    scopus 로고
    • Alpha-linolenic acid and riluzole treatment confer cerebral protection and improve survival after focal brain ischemia
    • Heurteaux C., Laigle C., Blondeau N., Jarretou G., Lazdunski M. Alpha-linolenic acid and riluzole treatment confer cerebral protection and improve survival after focal brain ischemia. Neuroscience 2006, 137:241-251.
    • (2006) Neuroscience , vol.137 , pp. 241-251
    • Heurteaux, C.1    Laigle, C.2    Blondeau, N.3    Jarretou, G.4    Lazdunski, M.5
  • 46
    • 81455154823 scopus 로고    scopus 로고
    • Alpha-linolenic omega-3 fatty acid for stroke protection: from brain preconditioning paradigm to nutrition
    • Blondeau N. Alpha-linolenic omega-3 fatty acid for stroke protection: from brain preconditioning paradigm to nutrition. OCL, Oléagineux, Corps Gras, Lipides 2011, 18:271-278.
    • (2011) OCL, Oléagineux, Corps Gras, Lipides , vol.18 , pp. 271-278
    • Blondeau, N.1
  • 47
    • 84867770901 scopus 로고    scopus 로고
    • Improved outcome after spinal cord compression injury in mice treated with docosahexaenoic acid
    • Lim S.N., Huang W., Hall J.C., Michael-Titus A.T., Priestley J.V. Improved outcome after spinal cord compression injury in mice treated with docosahexaenoic acid. Experimental Neurology 2012, 239C:13-27.
    • (2012) Experimental Neurology , vol.239 C , pp. 13-27
    • Lim, S.N.1    Huang, W.2    Hall, J.C.3    Michael-Titus, A.T.4    Priestley, J.V.5
  • 49
    • 0036169654 scopus 로고    scopus 로고
    • Impact of n-3 fatty acid supplemented parenteral nutrition on haemostasis patterns after major abdominal surgery
    • Heller A.R., Fischer S., Rossel T., Geiger S., Siegert G., Ragaller M., et al. Impact of n-3 fatty acid supplemented parenteral nutrition on haemostasis patterns after major abdominal surgery. British Journal of Nutrition 2002, 87(Suppl. 1):S95-S101.
    • (2002) British Journal of Nutrition , vol.87 , Issue.SUPPL. 1
    • Heller, A.R.1    Fischer, S.2    Rossel, T.3    Geiger, S.4    Siegert, G.5    Ragaller, M.6
  • 51
    • 0035399856 scopus 로고    scopus 로고
    • Activation of the nuclear factor-kappab is a key event in brain tolerance
    • Blondeau N., Widmann C., Lazdunski M., Heurteaux C. Activation of the nuclear factor-kappab is a key event in brain tolerance. Journal of Neuroscience 2001, 21:4668-4677.
    • (2001) Journal of Neuroscience , vol.21 , pp. 4668-4677
    • Blondeau, N.1    Widmann, C.2    Lazdunski, M.3    Heurteaux, C.4
  • 52
    • 0027323080 scopus 로고
    • Dietary alpha-linolenic acid at 1.3g/kg maintains maximal docosahexaenoic acid concentration in brain, heart and liver of adult rats
    • Bourre J.M., Dumont O., Pascal G., Durand G. Dietary alpha-linolenic acid at 1.3g/kg maintains maximal docosahexaenoic acid concentration in brain, heart and liver of adult rats. Journal of Nutrition 1993, 123:1313-1319.
    • (1993) Journal of Nutrition , vol.123 , pp. 1313-1319
    • Bourre, J.M.1    Dumont, O.2    Pascal, G.3    Durand, G.4
  • 53
    • 0014250448 scopus 로고
    • Requirements of the female rat for linoleic and linolenic acids
    • Pudelkewicz C., Seufert J., Holman R.T. Requirements of the female rat for linoleic and linolenic acids. Journal of Nutrition 1968, 94:138-146.
    • (1968) Journal of Nutrition , vol.94 , pp. 138-146
    • Pudelkewicz, C.1    Seufert, J.2    Holman, R.T.3
  • 56
    • 0034955012 scopus 로고    scopus 로고
    • The "Apports nutritionnels conseilles (anc)" for the French population
    • Martin A. The "Apports nutritionnels conseilles (anc)" for the French population. Reproduction, Nutrition, Development 2001, 41:119-128.
    • (2001) Reproduction, Nutrition, Development , vol.41 , pp. 119-128
    • Martin, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.