Inhibition of rotavirus replication by downregulation of fatty acid synthesis

Journal of General Virology

Volumn 94, Issue PART 6, 2013, Pages 1310-1317

  Gaunt, Eleanor R ^a   Cheung, Winsome ^a   Richards, James E ^a   Lever, Andrew ^a   Desselberger, Ulrich ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 FUROIC ACID DERIVATIVE; 5 TETRADECYLOXY 2 FUROIC ACID; ACETYL COENZYME A CARBOXYLASE; ACETYL COENZYME A CARBOXYLASE 1; C 75; FATTY ACID SYNTHASE; FURAN DERIVATIVE; SMALL INTERFERING RNA; TETRAHYDRO 4 METHYLENE 2R OCTYL 5 OXO 3S FURANCARBOXYLIC ACID; UNCLASSIFIED DRUG; VIRUS RNA;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; DOWN REGULATION; DRUG POTENTIATION; ENZYME INHIBITION; FATTY ACID METABOLISM; FATTY ACID SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; RNA SYNTHESIS; ROTAVIRUS; ROTAVIRUS INFECTION; VIRUS INFECTIVITY; VIRUS REPLICATION;

EID: 84877995912     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.050146-0     Document Type: Article

References (35)

1. Arnoldi, F., Campagna, M., Eichwald, C., Desselberger, U. & Burrone, O. R. (2007). Interaction of rotavirus polymerase VP1 with nonstructural protein NSP5 is stronger than that with NSP2. J Virol 81, 2128-2137.
2. Barba, G., Harper, F., Harada, T., Kohara, M., Goulinet, S., Matsuura, Y., Eder, G., Schaff, Zs., Chapman, M. J. & other authors (1997). Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets. Proc Natl Acad Sci U S A 94, 1200-1205.
3. Bartenschlager, R., Penin, F., Lohmann, V. & André, P. (2011). Assembly of infectious hepatitis C virus particles. Trends Microbiol 19, 95-103.
4. Cheung, W., Gill, M., Esposito, A., Kaminski, C. F., Courousse, N., Chwetzoff, S., Trugnan, G., Keshavan, N., Lever, A. & Desselberger, U. (2010). Rotaviruses associate with cellular lipid droplet components to replicate in viroplasms, and compounds disrupting or blocking lipid droplets inhibit viroplasm formation and viral replication. J Virol 84, 6782-6798.
5. Chukkapalli, V., Heaton, N. S. & Randall, G. (2012). Lipids at the interface of virus-host interactions. Curr Opin Microbiol 15, 512-518.
6. Clifford, G. M., Londos, C., Kraemer, F. B., Vernon, R. G. & Yeaman, S. J. (2000). Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytes. J Biol Chem 275, 5011-5015.
7. Eichwald, C., Vascotto, F., Fabbretti, E. & Burrone, O. R. (2002). Rotavirus NSP5: mapping phosphorylation sites and kinase activation and viroplasm localization domains. J Virol 76, 3461-3470.
8. Eichwald, C., Rodriguez, J. F. & Burrone, O. R. (2004). Characterization of rotavirus NSP2/NSP5 interactions and the dynamics of viroplasm formation. J Gen Virol 85, 625-634.
9. Estes, M. & Kapikian, A. (2007). Rotaviruses. In Fields Virology, 5th edn, pp. 1917-1974. Edited by D. M. Knipe, R. A. Lamb & P. M. Howley. Philadelphia: Kluwer Health/Lippincott, Williams and Wilkins.
10. Flavin, R., Peluso, S., Nguyen, P. L. & Loda, M. (2010). Fatty acid synthase as a potential therapeutic target in cancer. Future Oncol 6, 551-562.
11. Goodman, J. M. (2009). Demonstrated and inferred metabolism associated with cytosolic lipid droplets. J Lipid Res 50, 2148-2156.
12. Guseva, N. V., Rokhlin, O. W., Glover, R. A. & Cohen, M. B. (2011). TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status. Cancer Biol Ther 12, 80-85.
13. Heaton, N. S. & Randall, G. (2011). Multifaceted roles for lipids in viral infection. Trends Microbiol 19, 368-375.
14. Kapadia, S. B. & Chisari, F. V. (2005). Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids. Proc Natl Acad Sci U S A 102, 2561-2566.
15. Kibbe, W. A. (2007). OligoCalc: an online oligonucleotide properties calculator. Nucleic Acids Res 35 (Web Server issue), W43-W46.
16. Krogerus, C., Samuilova, O., Pöyry, T., Jokitalo, E. & Hyypiä, T. (2007). Intracellular localization and effects of individually expressed human parechovirus 1 non-structural proteins. J Gen Virol 88, 831-841.
17. Kuhajda, F. P., Landree, L. E. & Ronnett, G. V. (2005). The connections between C75 and obesity drug-target pathways. Trends Pharmacol Sci 26, 541-544.
18. Martin, S. & Parton, R. G. (2006). Lipid droplets: a unified view of a dynamic organelle. Nat Rev Mol Cell Biol 7, 373-378.
19. Matthijnssens, J., Otto, P. H., Ciarlet, M., Desselberger, U., Van Ranst, M. & Johne, R. (2012). VP6-sequence-based cutoff values as a criterion for rotavirus species demarcation. Arch Virol 157, 1177-1182.
20. Miyanari, Y., Atsuzawa, K., Usuda, N., Watashi, K., Hishiki, T., Zayas, M., Bartenschlager, R., Wakita, T., Hijikata, M. & Shimotohno, K. (2007). The lipid droplet is an important organelle for hepatitis C virus production. Nat Cell Biol 9, 1089-1097.
21. Parashar, U. D., Hummelman, E. G., Bresee, J. S., Miller, M. A. & Glass, R. I. (2003). Global illness and deaths caused by rotavirus disease in children. Emerg Infect Dis 9, 565-572.
22. Parker, R. A., Kariya, T., Grisar, J. M. & Petrow, V. (1977). 5-(Tetradecyloxy)-2-furancarboxylic acid and related hypolipidemic fatty acid-like alkyloxyarylcarboxylic acids. J Med Chem 20, 781-791.
23. Petrie, B. L., Graham, D. Y., Hanssen, H. & Estes, M. K. (1982). Localization of rotavirus antigens in infected cells by ultrastructural immunocytochemistry. J Gen Virol 63, 457-467.
24. Pizer, E. S., Thupari, J., Han, W. F., Pinn, M. L., Chrest, F. J., Frehywot, G. L., Townsend, C. A. & Kuhajda, F. P. (2000). Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. Cancer Res 60, 213-218.
25. Reed, L. J. & Muench, H. (1938). A simple method of estimating fifty per cent endpoints. Am J Epidemiol 27, 493-497.
26. Ruiz-Palacios, G. M., Pérez-Schael, I., Velázquez, F. R., Abate, H., Breuer, T., Clemens, S. C., Cheuvart, B., Espinoza, F., Gillard, P. & other authors (2006). Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis. N Engl J Med 354, 11-22.
27. Samsa, M. M., Mondotte, J. A., Iglesias, N. G., Assunção-Miranda, I., Barbosa-Lima, G., Da Poian, A. T., Bozza, P. T. & Gamarnik, A. V. (2009). Dengue virus capsid protein usurps lipid droplets for viral particle formation. PLoS Pathog 5, e1000632.
28. Schmid, B., Rippmann, J. F., Tadayyon, M. & Hamilton, B. S. (2005). Inhibition of fatty acid synthase prevents preadipocyte differentiation. Biochem Biophys Res Commun 328, 1073-1082.
29. Schneider, C. A., Rasband, W. S. & Eliceiri, K. W. (2012). NIH Image to ImageJ: 25 years of image analysis. Nat Methods 9, 671-675.
30. Simmonds, P. (2012). SSE: a nucleotide and amino acid sequence analysis platform. BMC Res Notes 5, 50.
31. Spencer, C. M., Schafer, X. L., Moorman, N. J. & Munger, J. (2011). Human cytomegalovirus induces the activity and expression of acetyl-coenzyme A carboxylase, a fatty acid biosynthetic enzyme whose inhibition attenuates viral replication. J Virol 85, 5814-5824.
32. Tate, J. E., Burton, A. H., Boschi-Pinto, C., Steele, A. D., Duque, J., Parashar, U. D. & WHO-coordinated Global Rotavirus Surveillance Network (2012). 2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes: a systematic review and meta-analysis. Lancet Infect Dis 12, 136-141.
33. Tennant, J. R. (1964). Evaluation of the trypan blue technique for determination of cell viability. Transplantation 2, 685-694.
34. Vesikari, T., Matson, D. O., Dennehy, P., Van Damme, P., Santosham, M., Rodriguez, Z., Dallas, M. J., Heyse, J. F., Goveia, M. G. & other authors (2006). Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine. N Engl J Med 354, 23-33.
35. Yen, C., Tate, J. E., Patel, M. M., Cortese, M. M., Lopman, B., Fleming, J., Lewis, K., Jiang, B., Gentsch, J. & other authors (2011). Rotavirus vaccines: update on global impact and future priorities. Hum Vaccin 7, 1282-1290.