TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status

Cancer Biology and Therapy

Volumn 12, Issue 1, 2011, Pages 80-85

  Guseva, Natalya V ^a   Rokhlin, Oskar W ^a   Glover, Rebecca A ^a   Cohen, Michael B ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Acetyl CoA carboxylase ; Cell death; Fatty acid synthesis; Mcl 1; Neuropilin 1; Prostate cancer; TOFA

Indexed keywords

5 TETRADECYL OXY 2 FUROIC ACID; ACETYL COENZYME A CARBOXYLASE; ANDROGEN RECEPTOR; ANDROSTANOLONE; CYTOCHROME C; FATTY ACID; NEUROPILIN 1; PROTEIN MCL 1; PROTEIN P53; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CARCINOGENICITY; CELL DEATH; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; FATTY ACID SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MALE; PROSTATE CANCER; PROTEIN EXPRESSION;

ACETYL-COA CARBOXYLASE; ANDROGEN RECEPTOR ANTAGONISTS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA; CELL DEATH; CELL LINE, TUMOR; CYTOCHROMES C; DIHYDROTESTOSTERONE; FATTY ACIDS; FURANS; GENES, P53; HUMANS; INTRONS; LIPIDS; MALE; MITOCHONDRIA; NEUROPILIN-1; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, ANDROGEN;

EID: 79959909727     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.12.1.15721     Document Type: Article

References (15)

1. Swinnen JV, Heemers H, Van de Sande T, De Schrijver E, Brusselmans K, Heyns W, et al. Androgens, lipogenesis and prostate cancer. J Steroid Biochem Molec Biol 2004; 92:273-9. (Pubitemid 40128248)
2. Heemers H, Maes F, Foufelle F, Heyns W, Verhoeven G, Swinnen JV. Androgens stimulate lipogenic gene expression in prostate cancer cells by activation of the sterol regulatory element-binding protein cleavage activating protein/sterol regulatory element-binding protein pathway. Mol Endocrinol 2001; 15:1817-28. (Pubitemid 32939311)
3. Rysman E, Brusselmans K, Scheys K, Timmermans L, Derua R, Munck S, et al. De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation. Cancer Res 2010; 70:8117-26.
4. Brusselmans K, Schrijver E, Verhoeven G, Swinnen JV. RNA interference-mediated silencing of the Acetyl-CoA carboxylase-α gene induces growth inhibition and apoptosis of prostate cancer cells. Cancer Res 2005; 65:6719-25. (Pubitemid 41060709)
5. Beckers A, Organe S, Timmermans L, Scheys K, Peeters A, Brusselmans K, et al. Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells. Cancer Res 2007; 67:8180-7. (Pubitemid 47395154)
6. Wang C, Xu C, Sun M, Luo D, Liao Df, Cao D. Acetyl-CoA carboxylase inhibitor TOFA induces human cancer cells apoptosis. Bioch Biophys Res Communic 2009; 385:302-6.
7. Rokhlin OW, Taghiyev AF, Guseva NV, Glover RA, Chumakov PM, Kravchenko JE, et al. Androgen regulates apoptosis induced by TNFR family ligands via multiple signaling pathways in LNCaP. Oncogene 2005; 24:6773-84. (Pubitemid 41487036)
8. Tang D, Lahti JM, Kidd VJ. Caspase-8 activation and Bid cleavage contribute to MCF7 cellular execution in caspase-3-dependent manner during staurosporine-mediated apoptosis. J Biol Chem 2000; 275:9303-7. (Pubitemid 30185152)
9. Rokhlin OW, Guseva NA, Taghiev AF, Glover RA, Cohen MB. KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer. Cancer Biol Ther 2010; 9:223-34.
10. Zhang S, Zhau H, Osunkoya AO, Iqbal S, Yang X, Fan S, et al. Vascular endothelial growth factor regulates myeloid cell leukemia-1 expression through neuropilin-1-dependent activation of c-MET signaling in human prostate cancer cells. Molec Cancer 2010; 9:9-22.
11. Gurova RV, Rokhlin OW, Budanov AV, Burdelya LG, Chumakov PM, Cohen MB, et al. Cooperation of two mutant p53 alleles contributes to Fas resistance of prostate carcinoma cells. Cancer Res 2003; 63:2905-12. (Pubitemid 36667163)
12. Warr MR, Shore GC. Unique biology of Mcl-1: therapeutic opportunities in cancer. Current Mol Med 2008; 8:138-47. (Pubitemid 351516833)
13. Webber MM, Bello D, Kleinman HK, Wartinger D, Williams DE, Rhim IS. Prostate specific antigen and androgen receptor induction and characterization of an immortalized adult human prostatic epithelial cell line. Carcinogenesis 1996; 17:1641-6. (Pubitemid 26280386)
14. Bello D, Webber MM, Kleinman HK, Wartinger DD, Rhim JS. Androgen responsive adult human prostatic epithelial cell lines immortalized by human papillomavirus 18. Carcinogenesis 1997; 18:1215-23. (Pubitemid 28132513)
15. Ma J, Yan R, Zu X, Cheng JM, Rao K, Liao DF, et al. Aldo-keto reductase family 1 B10 affects fatty acid synthesis by regulating the stability of acetyl-CoA carboxylase-α in breast cancer cells. J Biol Chem 2008; 283:3418-23.