Markers of operational immune tolerance after pediatric liver transplantation in patients under immunosuppression

Pediatric Transplantation

Volumn 17, Issue 4, 2013, Pages 348-354

  Schulz Juergensen, S ^a   Marischen, L ^a   Wesch, D ^a   Oberg, H H ^a   Fandrich F ^a   Kabelitz, D ^a   Burdelski, M ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

T cells; operational tolerance; pediatric liver transplantation; regulatory T cells; tolerance marker

Indexed keywords

EVEROLIMUS; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER;

ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; GAMMA DELTA T LYMPHOCYTE; GENE EXPRESSION PROFILING; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOSUPPRESSIVE TREATMENT; INFANT; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; PEDIATRIC SURGERY; PRESCHOOL CHILD; PROSPECTIVE STUDY; REGULATORY T LYMPHOCYTE; SCHOOL CHILD; T LYMPHOCYTE SUBPOPULATION;

ANTIGENS, CD3; BIOLOGICAL MARKERS; CELL SEPARATION; CHILD; CHILD, PRESCHOOL; FLOW CYTOMETRY; FOLLOW-UP STUDIES; HUMANS; IMMUNE TOLERANCE; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; INFANT; LIVER FAILURE; LIVER TRANSPLANTATION; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RETROSPECTIVE STUDIES; T-LYMPHOCYTES, REGULATORY; TIME FACTORS;

EID: 84877967309     PISSN: 13973142     EISSN: 13993046     Source Type: Journal    
DOI: 10.1111/petr.12079     Document Type: Article

References (27)

1. Soltys KA, Mazariegos GV, Squires RH, Sindhi RK, Anand R,. Late graft loss or death in pediatric liver transplantation: An analysis of the SPLIT database. Am J Transplant 2007: 7: 2165-2171.
2. Kelly D, Jara P, Rodeck B, et al. Tacrolimus and steroids versus ciclosporin microemulsion, steroids, and azathioprine in children undergoing liver transplantation: Randomised European multicentre trial. Lancet 2004: 364: 1054-1061.
3. Mazariegos GV, Sindhi R, Thomson AW, Marcos A,. Clinical tolerance following liver transplantation: Long term results and future prospects. Transplant Immunology 2007: 17: 114-119.
4. Feng S, Ekong UD, Lobritto SJ, et al. Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants. JAMA 2012: 307: 283-293.
5. Ramos HC, Reyes J, Abu-Elmagd K, et al. Weaning of immunosuppression in long-term liver transplant recipients. Transplantation 1995: 59: 212-217.
6. Takatsuki M, Uemoto S, Inomata Y, et al. Weaning of immunosuppression in living donor liver transplant recipients. Transplantation 2001: 72: 449-454.
7. Oike F, Yokoi A, Nishimura E, et al. Complete withdrawal of immunosuppression in living donor liver transplantation. Transplant Proc 2002: 34: 1521.
8. Reding R, Gras J, Bourdeaux C, et al. Stepwise minimization of the immunosuppressive therapy in pediatric liver transplantation. A conceptual approach towards operational tolerance. Acta Gastroenterol Belg 2005: 68: 320-322.
9. Ueda M, Oike F, Ogrua Y, et al. Long-term outcomes of 600 living donor liver transplants for pediatric patients at a single center. Liver Transplant 2006: 12: 1326-1336.
10. Sakaguchi S, Yamaguchi T, Nomura T, Ono M,. Regulatory T cells and immune tolerance. Cell 2008: 133: 775-787.
11. Kühl AA, Pawlowski NN, Grollich K, et al. Human peripheral γδ T cells possess regulatory potential. Immunology 2009: 128: 580-588.
12. Li Y, Koshiba T, Yoshizawa A, et al. Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation. Am J Transplant 2004: 4: 2118-2125.
13. Martinez-Llordella M, Puig-Pey I, Orlando G, et al. Multiparameter immune profiling of operational tolerance in liver transplantation. Am J Transplant. 2007: 7: 309-319.
14. Martinez-Llordella M, Lozano JJ, Puig-Pey I, et al. Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients. J Clin Invest 2008: 118: 2845-2857.
15. Demirkiran A, Kok A, Kwekkeboom J, Metselaar HJ, Tilanus HW, van der Laan LJ,. Decrease of CD4+ CD25+ T cells in peripheral blood after liver transplantation: Association with immunosuppression. Transplant Proc 2005: 37: 1194-1196.
16. Demirkiran A, Kok A, Kwekkeboom J, et al. Low circulating regulatory T-cell levels after acute rejection in liver transplantation. Liver Transplant 2006: 12: 277-284.
17. Pons JA, Revilla-Nuin B, Baroja-Mazo A, et al. FoxP3 in peripheral blood is associated with operational tolerance in liver transplant patients during immunosuppression withdrawal. Transplantation 2008: 86: 1370-1378.
18. Gupta P, Hart J, Cronin D, Kelly S, Millis JM, Brady L,. Risk factors for chronic rejection after pediatric liver transplantation. Transplantation 2001: 72: 1098-1102.
19. Ohe H, Waki K, Yoshitomi M, et al. Factors affecting operational tolerance after pediatric living-donor liver transplantation: Impact of early post-transplant events and HLA match. Transplant Int 2012: 25: 97-106.
20. Nijagal A, Fleck S, Hills NK, et al. Decreased risk of graft failure with maternal liver transplantation in patients with biliary atresia. Am J Transplant 2012: 12: 409-419.
21. Tryphonopoulos P, Weppler D, Morris MI, et al. The effect of donor-recipient cytomegalovirus serology on adult liver transplantation: A single center experience. Transplantation 2011: 92: 1051-1057.
22. Miroux C, Moralés O, Carpentier A, et al. Inhibitory effects of cyclosporine on human regulatory T cells in vitro. Transplant Proc. 2009: 41: 3371-3374.
23. Shepherd RW, Turmelle Y, Nadler M, et al., and the Split Research Group. Risk factors for rejection and infection in pediatric liver transplantation. Am J Transplant. 2008: 8: 396-403.
24. Li Y, Zhao X, Cheng D, et al. The presence of Foxp3 expressing T cells within grafts of tolerant human liver transplant recipients. Transplantation 2008: 86: 1837-1843.
25. Stenard F, Nguyen C, Cox K, et al. Decreases in circulating CD4+ CD25hiFOXP3+ cells and increases in intragraft FOXP3+ cells accompany allograft rejection in pediatric liver allograft recipients. Pediatr Transplant 2009: 13: 70-80.
26. Koshiba T, Li Y, Takemura M, et al. Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation. Transplant Immunol 2007: 17: 94-97.
27. Feng S,. Long-term management of immunosuppression after pediatric liver transplantation: Is minimization or withdrawal desirable and/or possible? Curr Opin Organ Transplant 2009: 13: 506-512.