Areca Nut Extract Induces Pyknotic Necrosis in Serum-Starved Oral Cells via Increasing Reactive Oxygen Species and Inhibiting GSK3β: An Implication for Cytopathic Effects in Betel Quid Chewers

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Ji, Wen Tsai ^a   Lee, Cheng I ^a   Chen, Jeff Yi Fu ^b   Cheng, Ya Ping ^a   Yang, Sheng Ru ^a   Chen, Jung Hua ^a   Chen, Hau Ren ^a  

^a NATIONAL CHUNG CHENG UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BETEL EXTRACT; CASPASE; GLYCOGEN SYNTHASE KINASE 3BETA; HISTONE H2AX; MAMMALIAN TARGET OF RAPAMYCIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROPIDIUM IODIDE; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BETEL NUT; CALCIUM TRANSPORT; CELL CULTURE; CELL DEATH; CELL NUCLEUS; CELL STRUCTURE; CELL VACUOLE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DNA FRAGMENTATION; DRUG ISOLATION; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOUTH CAVITY; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PYKNOSIS; WESTERN BLOTTING;

ARECA; AUTOPHAGY; CALCIUM SIGNALING; CASPASES; CELL LINE, TUMOR; CULTURE MEDIA, SERUM-FREE; ENZYME ACTIVATION; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INSULIN; MASTICATION; MODELS, BIOLOGICAL; MOUTH; NECROSIS; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES;

EID: 84877967113     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063295     Document Type: Article

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